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BRONCHIAL ASTHMA: AN UNMET DISEASE
Asthma is a chronic obstructive disease of airways affecting bronchi, resulting in bronchoconstriction, tightening of chest and airway inflammation. Asthma remains a disease with clearly unsatisfactory therapeutics. With the mounting evidence in support of asthma being an inflammatory illness, anti-inflammatory agents have now become prerequisite for the long-term management of asthma. Along with ...
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DETECTION OF ETHYLENE FOR IN VIRO EVALUATION OF THE UV PHOTOPROTECTION
In this study, the antioxidant capacity during UV exposure has been investigated by using a laser-based trace gas detector for the detection of gaseous ethylene as an indicator for lipid peroxidation. Biocream was used as a control and ascorbic acid, butylated hydroxytoluene, phloroglucinol and hydroquinone were added as antioxidants in a mixing concentration of 2.5% (w/w). The experimental result...
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1005
STABILITY INDICATING RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR PSEUDOEPHEDRINE HYDROCHLORIDE AND FEXOFENADINE HYDROCHLORIDE IN TABLET DOSAGE FORM
High performance liquid chromatographic (HPLC) method was described for determination of Pseudoephedrine Hydrochloride (PSE) and Fexofenadine Hydrochloride (FEX). The chromatographic separation was achieved on Kinetex C18, (250 x 4.6 mm i.d), Particle size 5µm. The mobile phase contains a mixture of 0.005 M Dioctyl Sodium Sulfosuccinate Buffer in a mixture of 50 volume of Methanol, 10 volume of A...
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1935
IN-VITRO AND IN-VIVO MODELS FOR ANTIOXIDANT ACTIVITY EVALUATION: A REVIEW
Antioxidants are gaining a lot of importance as a panacea for a large number of life-style diseases like aging, cancer, diabetes, cardiovascular and other degenerative diseases etc. owing to our sedentary way of life and stressful existence. Added to these are the deleterious effects of pollution and exposure to harmful chemicals. All the above cause may accumulation of harmful free radicals. The ...
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1894
“AGATHIYAR KUZHAMBU”- NOT ONLY A PURGATIVE- AN OVERVIEW
The Siddha System of Medicine is one of the most ancient traditional medical systems was popular in the ancient Southern part of India. In this system, the herbals, metals, minerals and animal products have been used to prepare the medicines for treating diverse illness. Siddha medicines are divided into inner drug treatments and external drug treatments. Agathiyar Kuzhambu is one among the 32 int...
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AN EFFICIENT SYNTHESIS OF 2-AMINOBENZOTHIAZOLE AND ITS DERIVATIVES IN IONIC LIQUIDS
The 2-aminobenzothiazole moiety and its derivatives have immense importance in medicinal and pharmaceutical chemistry as a potent biologically active molecules. The synthesis of 2-aminobenzothiazole derivatives carried out from substituted phenyl thiourea which is synthesized by substituted aniline in ionic liquid (1-butyl-3-methylimidazolium) bisulphate ([BMIM] + [HSO4]-), (1-butyl-3-methylimidaz...
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1752
ROLE OF ANTIOXIDANTS IN ORAL MEDICINE
The realization that reactive oxygen species and oxidative stress play an important role in the etiology and progression of major human degenerative diseases has triggered enormous and worldwide interest in endogenous and exogenous antioxidants. The 1990’s have seen the explosion of interest in antioxidants. The article reviews free radical chemistry, antioxidant systems & their role in huma...
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2093
EFFECT OF DIFFERENT CARBON AND NITROGEN SOURCES ON α- AMYLASE PRODUCTION FROM BACILLUS AMYLOLIQUEFACIENS
Amylases are among the most important enzymes in present-day biotechnology. The effects of various carbon and nitrogen sources on α-amylase production by submerged fermentation (smF) from Bacillus amyloliquefaciens was investigated. The study revealed that the levels of the α- amylase production varied greatly with the type and concentration of carbon and nitrogen sources used. The highest α-am...
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1249
COLUMN CHROMATOGRAPHIC SEPARATION OF BIOACTIVE COMPOUNDS FROM TAGETES ERECTA LINN.
Traditional medicines in many developing countries rely on the plant phytochemicals as a source of drug in curing many diseases. Tagetes erecta Linn. is an ornamental plant containing valuable therapeutic phytochemicals. In the current investigation, ethanol extraction of the dried flower sample was subjected to column chromatographic separation. Around 185 fractions were separated and recorded wi...
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MICROSPONGE DELIVERY SYSTEM (MDS): A UNIQUE TECHNOLOGY FOR DELIVERY OF ACTIVE INGREDIENTS
In pharmaceutical industry, various controlled released dosage forms like solid formulation, semi solid formulation and topical preparation have more importance due to efficacy and patient compliance. Topical preparations have some disadvantages like unpleasant odour, greasiness and skin irritation and fail to reach the systemic circulation in sufficient amounts in few cases. This problem is overc...
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