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A REVIEW ON NATURAL CHALCONES AN UPDATE
Plants are a valuable source of secondary metabolites. Many phytochemicals are obtained from the plant sources that are used as valuable medicinal agents. Chalcones are one of the important secondary metabolites obtained from many edible plants like foods, vegetables, tea, spices and natural foodstuffs. Chalcones considered as obligate intermediated in flavonoid biosynthesis but they do not accumu...
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NYCTANTHES ARBOR-TRISTIS A HERBAL PANACEA Pr
Nyctanthes arbor-tristis Linn. (NAT) is well known Indian medicinal plant. The plant is used in Ayurveda for various pharmacological actions such as anti-arthritic, antispasmodic, antibacterial, anti-inflammatory, immunostimulant, antidiabetic, hepatoprotective, antiarthritic, antioxidant, antimicrobial, antihelmintic, antileishmanial, antiviral, CNS depressant. The present review discusses phar...
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VALIDATED RP-HPLC METHOD FOR DETERMINATION OF ROSUVASTATIN CALCIUM IN BULK AND PHARMACEUTICAL FORMULATION
A rapid, sensitive and specific RP-HPLC method was developed and validated for determination of Rosuvastatin Calcium in bulk and tablet dosage form. Chromatography was carried out on a Enable C18G (250 x 4.6 mm i.d.,5µ) column using filtered and degassed mixture of acetonitrile and water in the ratio of 75:25 % v/v as mobile phase at a flow rate of 0.6 ml/min and effluent was monitored at 252 nm....
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STUDIES ON ANTIMICROBIAL AND ANTIOXIDANT PROPERTIES OF OYSTER MUSHROOM PLEUROTUS FLORIDA
The antimicrobial and antioxidant activity of four different solvent extracts of P. florida were investigated. The antimicrobial activities of different solvents were tested against different bacteria and fungi using disc diffusion method. Total antioxidant, reducing power and total phenolic content effect of the extracts was determined by phosphomolybdenum assay, 2,2-diphenyl-1-picrylhydrazyl (DP...
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OXIDATIVE STRESS INDUCED ALTERATION OF PROTEIN AND NUCLEIC ACID METABOLISM IN FLUORIDE-INTOXICATED RAT BRAIN: PROTECTION BY 3α-HYDROXY OLEAN-12-EN-27-OIC ACID ISOLATED FROM NEANOTIS WIGHTIANA
Increased production of reactive oxygen species plays important role in pathogenesis of chronic fluoride toxicity resulting from prolonged exposure to fluoride. Oral (NaF) fluoride administration to rats at 20 mg/kg b.w./day for 30 days resulted in elevation in MDA, free amino acid N2, NO level and decreased activities of SOD, GPx, CAT, GR and reduced non enzymatic antioxidant like GSH. Significan...
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FORMULATION AND CHARACTERIZATION OF INCLUSION COMPLEX OF ACETYL SALICYLIC ACID (ASPIRIN) AND β- CYCLODEXTRIN BY SOLVENT EVAPORATION & ITS COMPARATIVE STUDY TO ASPIRIN ALONE
The aim of present study was to determine whether pharmaceutical and pharmacological activity of aspirin would enhance in form of inclusion complex with β–cyclodextrin or not.Aspirin (Acetyl salicylic acid) a non steroidal anti-inflammatory drug, was formulated in to inclusion complex with β–cyclodextrin (β–CD) by solvent evaporation. The phase-solubility curve was AL type and Kst was fou...
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THROMBOLYTIC & CYTOTOXIC EFFECT OF DIFFERENT HERBAL EXTRACTS
An in-vitro thrombolytic model was used to check the clot lysis effect of four herbal extracts viz., Honey, Nigella sativa, Capsicum frutescens, Brassica oleracea, combination of Honey & Nigella sativa and Honey & Capsicum frutescens along with Streptokinase as a positive control and water as a negative control. And also brine shrimp lethality bio-assay was done using brine shrimp Nauplii ...
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IDENTIFICATION OF SMALL MOLECULE INHIBITORS AGAINST AMYLOID β (Aβ) OLIGOMERIZATION AND TOXICITY FROM NOOTROPIC AYURVEDIC HERBAL EXTRACTS
Central pathogenic mechanism of Alzheimer’s disease (AD) involves aggregation of amyloid β (Aβ) protein to form toxic oligomers. Identifying novel small molecules that inhibit the aggregation of monomeric Aβ to toxic oligomeric species can be an effective disease modifying strategy for AD. In the present study, plants being used in Ayurveda for treating dementia as well as to improve memory a...
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COMPARATIVE STUDY OF EFFECTS TWO β2 ADRENERGIC AGONISTS ON BIOCHEMICAL PARAMETERS IN MODERATE TO SEVERE BRONCHIAL ASTHMA PATIENTS
Background: β2- agonist drugs are frequently prescribed in asthmatics. Apart from bronchodilation they affect biochemical and physical parameters of the body. Method: Total 80 patients were divided into two groups. Group I (n=40) received Albuterol- 2.5mg./2.5ml. TDS and Group II (n=40) received Levalbuterol- 0.63mg./2.5ml, TDS via nebulizer for 4 weeks. Baseline and post-treatment estimatio...
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FORMULATION AND IN-VITRO EVALUATION OF SUN PROTECTION FACTOR IN A POLYHERBAL CREAM
Sunscreens aid the body's natural defense mechanisms to protect against harmful UV radiation from the sun. The present study involves the formulation of sunscreen cream with herbal active ingredients and evaluation for its effectiveness. Naturally occurring traditional substances are gradually replacing synthetic counterparts due to their effectiveness and absence of adverse effects. The herbal dr...
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