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ANTIDIABETIC ACTIVITY OF PIPER BETLE IN ALLOXAN INDUCED TYPE 1 DIABETIC MODEL RATS
The aim of this study was to investigate the potential antidiabetic activity of Piper betle in alloxen induced diabetics. Rats were divided into 6 groups and Piper betle was administered containing 50, 100 and 200 mg/kgbwt powder, respectively in 1ml water orally in group A, B and C rats. Metformin (150 mg/kgbwt) used as a reference standard drug. Blood glucose (BG), triglycerides (TG), total chol...
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REVIEW OF NATURAL PRODUCTS FROM MARINE ORGANISMS IN THE RED SEA
The marine environment is a rich source of both biological and chemical diversity. This diversity has been the source of unique chemical compounds with potential for drug development. In recent years, a significant number of novel metabolites with potent pharmacological properties have been discovered from the marine organisms. Specifically, the Red Sea is a natural source of these bioactive compo...
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EXTRACTION, ISOLATION AND CHEMICAL STRUCTURE ELUCIDATION OF DAIDZEIN FROM BARK OF ACACIA ARABICA (LAM.) WILLD OF BHOPAL, MADHYA PRADESH, INDIA
Purpose: To extract, isolate and identify daidzein from the bark of Acacia Arabica (Lam.) Willd of Bhopal, Madhya Pradesh, India. Methods: Succesesive methanolic extract from the bark of Acacia arabica was subjected to column chromatography and fractionated by benzene, n-butanol, and acetone successively. Eluents having similar Rf values were pooled together. These pools were subjected to flavonoi...
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IN VITRO STUDIES OF AMLODIPINE BESYLATE TABLET AND COMPARISON WITH FOREIGN BRAND LEADER IN NEPAL
The aim of this study was to investigate the physicochemical properties of amlodipine besylate tablets. Tablets containing 5 mg of amlodipine besylate were prepared using Generally Regarded as Safe (GRAS) excipients. Preformulation studies were carried out using Fourier Transform Infrared (FTIR) spectroscopy and High Performance Liquid Chromatography (HPLC). Dissolution studies were performed to a...
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OPERCULINA TURPETHUM AS A PANORAMIC HERBAL MEDICINE: A REVIEW
O. turpethum is the source of the drug known as Turpeth or Indian Jalap and it is widely grown throughout India and it is occasionally cultivated in gardens as an ornament. It has been used as a traditional medicine in many countries. The root is prescribed in scorpion sting and snake bite. The roots are bitter, acrid, sweet, thermogenic, purgative, carminative, antihelmintic, expectorant, antipyr...
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EVALUATION OF α-AMYLASE, α-GLUCOSIDASE AND ALDOSE REDUCTASE INHIBITORS IN ETHYL ACETATE EXTRACTS OF ENDOPHYTIC FUNGI ISOLATED FROM ANTI-DIABETIC MEDICINAL PLANTS
Twenty two endophytic fungi were isolated from anti-diabetic plants Momordica charantia and Trigonella foenum-graceum. Ethyl acetate extracts of all fungal isolates were tested for inhibition of aldose reductase and carbohydrate metabolizing enzymes. Ethyl acetate extracts of nine endophytic fungi were found to be positive for α- amylase and α- glucosidase inhibitors. Crude extracts of fungal is...
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PHARMACOLOGICAL OVERVIEW OF FREEZE DRIED ANDAMAN NONI (MORINDA CITRIFOLIA.L) AGAINST CANCER AND NEUROLOGICAL DISORDER
Noni (Morinda citrifolia) is one of the important traditional medicinal plants have been used by Polynesia over a period of 2000 years. Morinda citrifolia belongs to family Rubiaceae (Coffee family) which is an evergreen small sized tree, with glossy and deeply veined leaves found in tropical regions and islands of South Pacific, West Indies, India, Africa, and Australia. Noni fruit juice tradit...
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PHARMACOLOGICAL POTENTIALS OF MORINGA OLEIFERA LAM.: A REVIEW
The aim of this literature review was to provide advance research information for the future scientists to discover new drug molecules from the medicinal plant, Moringa oleifera Lam. (Moringaceae). The plant provides a rich and rare combination of zeatin, quercetin, beta-sitosterol and kaempferol. In addition to its high nutritional value, Moringa oleifera Lam is very important for its medicina...
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HUMAN RED BLOOD CELL MEMBRANE STABILITY TESTING FOR THE ESTIMATION OF ANTI-INFLAMMATORY ACTIVITY OF METHANOLIC EXTRACT OF MILLETTIA PACHYCARPA BENTH LEAVES
The present study is carried out with the methanolic extract of leaves of Millettia pachycarpa benth. Traditional use of it inspired us to investigate the blood corpuscular protective power of this plant as it used as blood tonic in Chinese traditional medicine. By the phytochemical screening we have both flavonoids and steroids. There’s also alkaloids are found which have extensive physiologic ...
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ANTI-INFLAMMATORY ACTIVITY OF METHANOLIC EXTRACT OF BRASSICA JUNCEA SEED ON CARRAGEENAN INDUCED PAW EDEMA IN RATS
Inflammation is a primary physiological defense mechanism that helps the body to protect itself from infection, toxic chemicals, or other noxious stimuli. The methanolic seeds extract of Brassica juncea was evaluated for its anti-inflammatory activity, in-vivo methods. Anti-inflammatory drugs with low toxicity and higher therapeutic values. It is a defensive mechanism of the body to remove the inj...
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