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FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF ACETAMINOPHEN
The present research work has been carried out for an optimized formulation of co-processed directly compressible vehicles in the preparation of the Acetaminophen mouth fast dissolving tablets (MFDTs). Acetaminophen was chosen due to its poor compression properties. Di-calcium Phosphate(DCP) was incorporated in the neutralized aqueous starch dispersion to prepare co-processed excipient. Co-process...
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ANTIOXIDANT AND ANTILEUKEMIC ACTIVITY OF VITEX NEGUNDO LEAF EXTRACTS
Vitex negundo is an Indian medicinal plant used to cure several diseases such as asthama, fever, headache, cancer and many other diseases. This study aims to determine the antioxidant potential and anti-proliferative activity of Vitex negundo methanolic leaf extract. Isolation of bioactive compounds involved liquid-liquid extraction of methanolic leaf extract by petroleum ether and chloroform. The...
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ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES OF VARIOUS BREAD FRUIT LEAVES (ARTOCARPUS ALTILIS (PARKINSON) FOSBERG)
Breadfruit (Artocarpus altilis (Parkinson) Fosberg) empirically has been used in certain communities in Indonesia as a traditional medicine. Biosynthesis process can change colour leaves of breadfruit from green leaves (GL), yellow leaves (YL), fallen yellow (FY), fallen dry (FD), and the process fermentation of green leaves become fermented green (FG). The purpose of this study was to determine w...
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PHYTOCHEMISTRY, ANTI-CANCER AND ANTI-INFLAMMATORY ACTIVITIES OF SOLVENT LEAF EXTRACTS OF NYCTANTHES ARBOR – TRISTIS
Ayurveda is one of the oldest systems of medicine that uses plants and their extracts for treatment and management of various diseased states. Nyctanthes arbour - tristis Linn. (Family Oleaceae), which has long been used traditionally for various medicinal purposes in the Indian sub continent. Each part of the plant has some important medicinal value and is thus commercially exploitable. It is now...
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BIOCIDAL EFFICACY OF SYNTHETIC COPOLYESTERS HAVING CHALCONE MOIETY
Two chalcone diols (2E)-1-(4-hydroxyphenyl)-3(4-hydroxy, 3-ethoxy phenyl) prop-en-1-one and (2E)-1-(4-hydroxy-3-methoxy phenyl)-3(4-hydroxy, 3-ethoxy phenyl) prop-en-1-one were synthesized by acid catalyzed ClaisenSchmidt reaction. The synthesized chalcones were made to undergo polymerization using three aliphatic dichlorides namely glutaryl, succinyl and oxalyl chlorides. The polymers were random...
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A STUDY ON ASSESSMENT OF KNOWLEDGE, ATTITUDE AND PRACTICE REGARDING PHARMACOVIGILANCE AMONG HEALTHCARE PROFESSIONALS IN A TERTIARY CARE HOSPITAL, ANDHRA PRADESH
Objectives: The aim of this study was to assess knowledge, attitude and practice of the healthcare professionals about Pharmacovigilance in a tertiary care hospital, Rajahmundry, Andhra Pradesh. Materials and Methods: A cross-sectional questionnaire based study was carried out on healthcare professionals (Faculties, Postgraduates, Interns & Nurses) to assess the knowledge, attitude and practic...
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RECENT ADVANCES IN HOT MELT EXTRUSION TECHNOLOGY
Melt extrusion process which is well known in the polymer and food industry is now being used for pharmaceutical manufacturing to create innovative new formulations and is a continuous process of mixing and designing moldable materials. It is one of the most widely applied processing techniques useful for preparing solid dosage forms, granules, pellets, suppositories, implants, stents, ophthalmic ...
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PHOSPHATIDYLCHOLINE: A REVOLUTION IN DRUG DELIVERY TECHNOLOGY
In recent years Phosphatidylcholine has greatly impacted the drug delivery technology. The very first and most important advantage of phospholipid based vesicular system is the compatibility of phospholipids with membrane of human either internal membrane as well as skin (external membrane). For a drug to be absorbed and distributed into organs and tissues and eliminated from the body, it must pas...
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DEVELOPMENT AND VALIDATION OF A NEW HPLC METHOD FOR THE ESTIMATION OF AZITHROMYCIN IN BULK AND TABLET DOSAGE FORM
A simple, reproducible and efficient reversed phase high performance liquid chromatographic (RP-HPLC) method has been developed for quantitative determination of azithromycin in drug substance. The separations were carried out on a Xterra C18 column (150 ×4.6 mm; 5µ) with UV detection at 215 nm. The mobile phase consisting of acetonitrile and phosphate buffer (pH adjusted to 7.5) in a ratio of 5...
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ASSESSMENT OF ANTIOXIDANT ACTIVITY AND PHYTOCHEMICAL SCREENING OF COLOCASIA ESCULENTA CORM
Colocasia esculenta corm aqueous extract was assessed for its in vitro antioxidant capacity and free radical scavenging potential by seven different assays, viz. total phenolic content, total flavonoid content, total flavonol content, reducing power estimation as well as 1,1-diphenyl-2-picrylhydrazyl (DPPH), nitric oxide (NO) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radic...
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