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A VALIDATED RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF METRONIDAZOLE AND CIPROFLOXACIN HYDROCHLORIDE IN PHARMACEUTICAL DOSAGE FORM
A reversed-phase-liquid chromatographic (RP-HPLC) method was developed for the determination of Metronidazole (MTZ) and Ciprofloxacin HCl (CPX) in their bulk drug and marketed formulations. The separation was carried out using a mobile phase of 25mM Potassium dihydrgen phosphate buffer of pH 3.0 consisting of 0.15%v/v Triethylamine, 0.1% Phosphoric acid and Methanol in the ratio of( 60:40v/v). T...
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PHYTOCHEMISTRY, ANTI-CANCER AND ANTI-INFLAMMATORY ACTIVITIES OF SOLVENT LEAF EXTRACTS OF NYCTANTHES ARBOR – TRISTIS
Ayurveda is one of the oldest systems of medicine that uses plants and their extracts for treatment and management of various diseased states. Nyctanthes arbour - tristis Linn. (Family Oleaceae), which has long been used traditionally for various medicinal purposes in the Indian sub continent. Each part of the plant has some important medicinal value and is thus commercially exploitable. It is now...
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PROBIOTICS, PREBIOTICS AND SYNBIOTICS
The benefits of Probiotics have been recognized and explored for over a century. Probiotics consist of bacteria or yeasts and can be considered functional foods that can re-colonize and restore the microflora symbiosis of the intestinal tract. Several health benefits associated with the Probiotics in various diseases includes Inflammatory Bowel Disease (IBD), Colon Cancer, Rotavirus-associated dia...
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ENHANCEMENT OF DISSOLUTION RATE OF CIPROFLOXACIN BY USING VARIOUS SOLID DISPERSION TECHNIQUES
The aim of this research wok is to formulate and evaluate Ciprofloxacin solid dispersions system by using the different techniques. This will increase the solubility of the drug or Ciprofloxacin and give the immediate release of the drug from the formulations. The main objective is to formulate a drug product as immediate release oral solid dosage form of Ciprofloxacin solid dispersion system whic...
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CLINICAL PHARMACIST INTERVENTIONS IN DRUG THERAPY IN PATIENTS WITH DIABETES MELLITUS AND HYPERTENSION IN A UNIVERSITY TEACHING HOSPITAL
Introduction: Drug related problems occur commonly in patients who often receive polypharmacy with multiple co-morbid conditions. This constitutes a major health problem because of their negative consequences with increased morbidity and mortality. Aims and Objectives: The aim of the study was to assess the impact of clinical pharmacist interventions in drug therapy in hospitalized diabetes mellit...
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ISOLATION AND PURIFICATION OF AN EXTRACELLULAR PROTEASE FROM BACILLUS SUBTILIS ASASBT ISOLATED FROM TERMITE SOIL
Proteases are one of the most important enzymes in many industrial applications, particularly as additives in laundry detergent industry. Hence, the present study investigates the isolation and purification of an extracellular protease from the Bacillus subtilis ASASBT isolated from termite soil sample. Among the five protease producers, one of the isolates was selected for further studies. It w...
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FUSED HETEROCYCLES AS A POTENT BIOLOGICAL AGENTS; RECENT ADVANCEMENT
Recently the synthesis of fused heterocyclic compounds seeks great attention of researches in the field of medicinal chemistry. Majority of the drug compounds contains heterocyclic ring in their structures and these heterocyclic skeleton contributes significantly in the biological profile of drug. The heterocyclic compound play significant role in synthetic chemistry and many heterocyclic derivati...
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EXPLORING THE BIOLOGICALLY ACTIVE METABOLITES OF ISOCHRYSIS GALBANA IN PHARMACEUTICAL INTEREST: AN OVERVIEW
Microalgae biomass has been recognized to have great potential as a source of novel bioactive compounds with industrial as well as health promoting applications in human, animal and aquatic lives. Microalgae have been gaining attention continuously due to its bioactive compounds. These bioactive compounds are primary and secondary metabolites produced by microalgae in order to adopt adverse enviro...
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BURN HEALING POTENTIAL OF NIGELLA SATIVA SEED OIL IN RATS
Nigella sativa L. (Black cumin) has showed a broad spectrum of pharmacological effects like antipyretic, analgesic, anti-inflammatory and antimicrobial. These activities may be related to the seeds oil. The most important chemical composition of hexanic extract of seeds was unsaturated fatty acids and essential oil. In this investigation the hexanic extract of seeds was topically applied to evalua...
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FORMULATION AND EVALUATION OF DICLOFENAC POTASSIUM MATRIX TABLETS
The objective of the study was to develop HPMC matrix tablets for oral controlled/ sustained release of water soluble Diclofenac Potassium. Sustained release matrix tablets containing 100 mg of Diclofenac Potassium were developed using different drug polymer ratio of HPMC. Tablets were prepared by direct compression. Compressed tablets were evaluated for uniformity of weight, content of active ing...
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