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ENHANCEMENT OF BIOAVAILABILITY OF CARVEDILOL USING SOLVENT DEPOSITION TECHNIQUES
Objective: Bioavailability is the key determinant of a drug for its therapeutic effectiveness, which in turn depends upon the solubility of that drug in gastro intestinal fluid. Carvedilol is a BCS class II drug. These category of drugs have low solubility and high permeability so their bioavailability is less. Solvent deposition is a promising method to improve the solubility of poorly water solu...
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EFFECT OF CADMIUM EXPOSURE ON CHOLINERGIC SYSTEM AND ENERGY METABOLISM OF RAT BRAIN: REVERSAL EFFECT OF α-TOCOPHEROL
Cadmium (Cd) is a toxic heavy metal in the environment. The aim of this study was to investigate the potential effect of Cd on cholinergic and bioenergetic systems in three brain regions: cerebral cortex, cerebellum and hippocampus. The young albino rats (3 months) were exposed to low dose of Cd (1.5 mg/kg body weight) and high dose of Cd (3 mg/kg body weight) through intraperitoneal injection dai...
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SOLID LIPID NANOPARTICLES: AN ADVANCED DRUG DELIVERY SYSTEM
Solid lipid nanoparticles are at the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery, research and clinical medicine, as well as in other varied sciences. Solid lipid nanoparticle (SLN) dispersions have been proposed as a new type of colloidal drug carrier system suitable for intravenous administration. Solid lipid nanoparticles (SLN...
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FORMULATION AND EVALUATION OF FAST DISSOLVING TABLET OF PARACETAMOL AND CHLORPHENIRAMINE MALEATE
The aim of the present work was to formulate and evaluate Fast Dissolving Tablet (FDT) of a combined oral dosage form of Paracetamol (PCM) and Chlorpheniramine Maleate (CPM). Paracetamol is an antipyretic and Chlorpheniramine maleate is an antihistamine used to relieve symptoms of hay fever, allergy, and the common cold. Combining both the drugs can be used as pain-relieving and fever in cold and ...
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MICROENCAPSULATION OF ISONIAZID BY TEMPERATURE CHANGE METHOD: PREPARATION AND CHARACTERIZATION
Aim: Isniazid is unstable in aqueous medium. The aim is to improve the aqueous stability of isoniazid by microencapsulation method. Methods: Isoniazid microcapsules were prepared by temperature change method. Ethyl cellulose used as coating material which forms a layer on pure drug. Ethyl cellulose was insoluble in cold cyclohexane when temperature rise about 70-750C it become soluble in cyc...
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EFFECT OF FRUIT JUICE ON THE DISSOLUTION OF DICLOFENAC SODIUM SUSTAINED RELEASE MATRIX TABLETS
In vitro dissolution of ten brands of diclofenac sodium sustained release matrix tablets were studied to determine the effect of fruit juice in the bioavailability of diclofenac. Significant reduction was observed in the release rate at all collected brands, where except sample D7 and D8 others were not fulfill the USP in vitro dissolution specification when administered with fruit juice. Therefor...
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ADEMETIONINE IN TREATMENT OF DRUG INDUCED LIVER INJURY: AN OBSERVATIONAL STUDY IN RUSSIAN PATIENTS, RECEIVING IMMUNOSUPPRESSIVE THERAPY FOR PSORIASIS
Background: Drug induced liver injury (DILI), especially; due to use of immunosuppressive agents is a growing concern. Lack of awareness about available treatment options limits its management. This observational study was conducted to characterize Russian population receiving ademetionine as a hepatoprotectant against DILI triggered due to immunosuppressive drugs. Methods: A total of 105 patients...
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EVALUATION OF ANTI-MICROBIAL ACTIVITY OF IN VITRO AND IN VIVO PLANT PARTS OF MERREMIA DISSECTA AND MERREMIA AEGYPTIA
The present study deals with the evaluation of the antimicrobial activity in methanolic extracts of in vivo (leaf, stem and seed) and in vitro (callus) plant parts of Merremia dissecta and Merremia aegyptia belonging to family Convolvulaceae. The antimicrobial activity against six different microbial strains, four bacterial viz. Bacillus thuringiensis, Bacillus subtilis, Eschrechia coli and Pseudo...
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PHYTOCHEMICAL SCREENING AND CHROMATOGRAPHIC EVALUATION OF FICUS BENGHALENSIS LEAVES
Aim: To rationalize the macroscopial, anatomical and physico- chemical studies on leaves of Ficus benghalensis (Maraceae). Materials & methods: The crude ethanolic extract of leaves of Ficus benghalensis (Maraceae) was using Physico-chemical parameters, and Preliminary photochemical investigation (TLC, HPTLC, & Column Chrmatography). Results and conclusion: An attempt had been made to high...
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SIGNIFICANCE OF CA 125 AND CEA AS BIOMARKERS IN ASSESSING PROGRESS OF TREATMENT FOR CERVICAL CANCER
Background: Cervical cancer (CC) is the second leading cause of cancer deaths in women, with more than 80% of these occurring in developing countries that have limited access to screening programs. Therefore there is a need to develop diagnostic and prognostic biomarkers which can be quantifiable and help clinical oncologists at the first interaction with the suspected patients. The aim of this st...
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