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EFFECT OF FRUIT JUICE ON THE DISSOLUTION OF DICLOFENAC SODIUM SUSTAINED RELEASE MATRIX TABLETS
In vitro dissolution of ten brands of diclofenac sodium sustained release matrix tablets were studied to determine the effect of fruit juice in the bioavailability of diclofenac. Significant reduction was observed in the release rate at all collected brands, where except sample D7 and D8 others were not fulfill the USP in vitro dissolution specification when administered with fruit juice. Therefor...
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ENHANCEMENT OF BIOAVAILABILITY OF CARVEDILOL USING SOLVENT DEPOSITION TECHNIQUES
Objective: Bioavailability is the key determinant of a drug for its therapeutic effectiveness, which in turn depends upon the solubility of that drug in gastro intestinal fluid. Carvedilol is a BCS class II drug. These category of drugs have low solubility and high permeability so their bioavailability is less. Solvent deposition is a promising method to improve the solubility of poorly water solu...
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ANTIMICROBIAL ACTIVITY OF ALTERNANTHERA BETTZICKIANA (REGEL) G. NICHOLSON AND ITS PHYTOCHEMICAL CONTENTS
The present investigation evaluates preliminary phytochemical screening and antimicrobial activity of aerial parts of Alternanthera bettzickiana (Regel) G. nicholson an edible green medicinal herb tested against various Gram positive, Gram negative bacteria and fungi. The plants were evaluated against two Gram positive bacterial species such as Staphylococcus aureus and Enterococcus faecalis; two ...
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EXTRACTION AND QUANTIFICATION OF PIGMENTS FROM INDIAN TRADITIONAL MEDICINAL PLANTS: A COMPARATIVE STUDY BETWEEN TREE, SHRUB AND HERB
Chlorophyll and carotenoids are important photosynthetic pigments found in higher plants, cyanobacteria and algae. Carotenoids are responsible for bright red, yellow and orange color in many fruits and vegetables. These two pigments play an important role in plant health. Chlorophyll and carotenoids are reported to contain anticancer properties. Chlorophyll and carotenoids protect skin and help in...
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PHARMACOKINETICS AND PHARMACODYNAMICS OF ELORES IN COMPLICATED URINARY TRACT INFECTIONS CAUSED BY EXTENDED SPECTRUM BETA-LACTAMASE STRAINS.
The pharmacokinetic/pharmacodynamic indices generally predict the efficacy of antibiotics when used alone. The information related to these indices for the combination products and that too in cases of resistant bacterial infections is limited. The present study involved treatment of 12 subjects with severe complicated urinary tract infections caused by resistant extended spectrum beta lactamase b...
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FORMULATION AND EVALUATION OF SOLID DISPERSION OF OLANZEPINE
The poor dissolution rate of water-insoluble drugs is still a major problem conforming the pharmaceutical industry. The most common method for improving the solubility is by increasing the surface area of the drug through micronization. But, in practice the effect of micronization is often disappointing, especially when the drugs are encapsulated or tablet. It is generally recognized that low solu...
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ANTI-INFLUENZA POTENTIAL OF ALKALOIDAL MOLECULES OF JATROPHA CURCAS LEAVES
Background: The Influenza viruses are major etiologic agents of human respiratory infections, and inflict sizable health and economic burden. Methods: The present study reports the in-vitro antiviral effect of isolated alkaloidal compound of Jatropha curcas leaves against Influenza virus by Hemagglutination (HA) reduction assay in two different layouts of simultaneous and post-treatment assay. The...
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CANAVALIA VIROSA ROXB.: A REVIEW
Man has been dependent on plants for the treatment and cure of different diseases since time immemorial. Plants have served not only as a source of food and shelter but also as a very important source of different “portions” used for the treatment and cure of diseases. These portions are herbal or plant based mixtures made by traditional healers; who are individuals having a knowledge of medic...
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SIGNIFICANCE OF CA 125 AND CEA AS BIOMARKERS IN ASSESSING PROGRESS OF TREATMENT FOR CERVICAL CANCER
Background: Cervical cancer (CC) is the second leading cause of cancer deaths in women, with more than 80% of these occurring in developing countries that have limited access to screening programs. Therefore there is a need to develop diagnostic and prognostic biomarkers which can be quantifiable and help clinical oncologists at the first interaction with the suspected patients. The aim of this st...
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ADEMETIONINE IN TREATMENT OF DRUG INDUCED LIVER INJURY: AN OBSERVATIONAL STUDY IN RUSSIAN PATIENTS, RECEIVING IMMUNOSUPPRESSIVE THERAPY FOR PSORIASIS
Background: Drug induced liver injury (DILI), especially; due to use of immunosuppressive agents is a growing concern. Lack of awareness about available treatment options limits its management. This observational study was conducted to characterize Russian population receiving ademetionine as a hepatoprotectant against DILI triggered due to immunosuppressive drugs. Methods: A total of 105 patients...
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