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OXIDATIVE STRESS INDUCED ALTERATION OF PROTEIN AND NUCLEIC ACID METABOLISM IN FLUORIDE-INTOXICATED RAT BRAIN: PROTECTION BY 3α-HYDROXY OLEAN-12-EN-27-OIC ACID ISOLATED FROM NEANOTIS WIGHTIANA
Increased production of reactive oxygen species plays important role in pathogenesis of chronic fluoride toxicity resulting from prolonged exposure to fluoride. Oral (NaF) fluoride administration to rats at 20 mg/kg b.w./day for 30 days resulted in elevation in MDA, free amino acid N2, NO level and decreased activities of SOD, GPx, CAT, GR and reduced non enzymatic antioxidant like GSH. Significan...
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TASTE MASKING BY ION EXCHANGE RESIN AND ITS NEW APPLICATIONS: A REVIEW
More than 50% of pharmaceutical products are orally administered for several Reasons and undesirable taste is one of the important formulation problems that is Encountered with such oral products. Taste of a pharmaceutical product is an important parameter governing compliance. Hence taste masking of oral Pharmaceuticals has become important tool to improve patient compliance and the Quality of tr...
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INVESTIGATING THE EFFECT OF MOLECULAR WEIGHT OF POLYVINYLPYRROLIDONE AND HYDROXYPROPYL METHYL CELLULOSE AS POTENTIAL ANTIPRECIPITANTS ON SUPERSATURATED DRUG SOLUTIONS AND FORMULATIONS USING WEAKLY ACIDIC DRUG: INDOMETHACIN
Most of the drug discovered in past decade belongs to biopharmaceutical classification system (BCS) class II. The solubility of these drugs is the limiting factor for oral bioavailability. The drug can be present in solution in a supersaturated state; however, it has a tendency to crystallize out. In this paper, we aim to study the effect of molecular weight of Polyvinylpyrrolidone (PVP) (PVP K12,...
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A COMPARATIVE STUDY OF THERAPEUTIC EFFECTS AND TOLERABILITY PROFILE OF CILNIDIPINE VERSUS AMLODIPINE IN MILD TO MODERATE ESSENTIAL HYPERTENSION
High Blood pressure or hypertension is one of the most ubiquitous yet nettle some medical problems that physician and health care provider face in the office. In present study amlodipine and cilnidipine have been selected to evaluate and compare their efficacy and tolerability in mild to moderate essential hypertension. 60 patients of uncomplicated mild to moderate essential hypertension were eval...
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PHARMACOGNOSTIC EVALUATION OF SUFOOF – E – HAZIM
Sufoof - e -Hazim (SEH), Unani formulation with high therapeutic efficacy, has been reported to cure indigestion and flatulence. The formulation is available with different manufacturers but scientific data on its pharmacognosy is lacking. Hence, the current research work is an attempt to standardize the formulation and establish quality control parameters in terms of its phytochemical and chromat...
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NUTRITIONAL ASSESSMENT OF DIFFERENT PARTS OF ACACIA CATECHU WILLD. COLLECTED FROM CENTRAL INDIA
Acacia catechu is a multipurpose tree predominantly found in tropical and subtropical regions of India. The tree produces nitrogen rich fodder and green manure, high quality fuel wood and charcoal, strong durable poles and timber. The most useful products of this tree are Kutch or “Kattha” which is obtained from bark and heartwood of the tree. Commonly used plant part of Acacia catechu is bark...
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MIDAZOLAM SOLUBILITY ENHANCEMENT PRE-FORMULATION TECHNIQUES AT NASAL PHYSIOLOGICAL pH
Midazolam is used as short-acting pre-anesthetic benzodiazepine with solubility of <0.1mg/mL at neutral-pH, which increases considerably in acidic media. Midazolam commercial acidic aqueous parenteral formulation (pH~3.3) causes pain and inflammation at administration site, which induces low patient-compliance. According to the absence of non-parenteral formulation, available parenteral dosage-...
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VERIFICATION STRATEGIES FOR ESTABLISHING RELIABILITY AND VALIDITY IN PHARMACEUTICAL MANUFACTURING PROCESS- AN ENROUTE TO REGULATORY COMPLIANCE
The Process validation involves a series of activities over the lifecycle of the product and process. The FDA guidance described three stages of process validation which includes Process Design, Process Qualification, and Continued Process Verification (CPV). The CPV stage is a never ending approach that continues throughout the entire commercial lifecycle of the product. CPV is dependent on compl...
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DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF GLYCOGEN SYNTHASE KINASE-3β INHIBITORS AS ANTIDIABETIC AGENTS
To synthesize structurally modified novel Glycogen Synthase Kinase-3βinhibitors to overcome insulin resistance in type 2 diabetes mellitus and to overcome associated health problems with reducing morbidity, mortality and economic costs of diabetes. Methods. Nineteen Phenylmethylene hydantoin analogs were designed and docked in the ATP binding site of GSK-3β by Molegro Virtual Docker 2006.1.5...
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1930
THE ANTIBACTERIAL ACTIVITIES OF SYZYGIUM AROMATICUM (L.) MERR. & PERRY AGAINST ORAL BACTERIA AND ITS ANTIOXIDANT AND ANTIMUTAGENIC ACTIVITIES
Plants are an important source of substances which are claimed to induce biological activities. Although there are a few studies on antimicrobial and antioxidant activities of this plant, antimutagenic activity has not been studied and there is no study in Turkey. Antibacterial activities of Syzygium aromaticum against oral pathogens have not been reported until today. The scope of this work was t...
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