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PLANTEROSOMES: A POTENTIAL PHYTO-PHOSPHOLIPID CARRIERS FOR THE BIOAVAILABILITY ENHANCEMENT OF HERBAL EXTRACTS
Planterosomes, term “PLANTERO” means plant while “SOME” means cell-like. A novel emerging technique applied to phytopharmaceutical for the enhancement of bioavailability of herbal extract for medicinal applications. Since the two major limiting factors for molecules to pass the biological membrane for their absorption in the blood stream mainly includes lipid solubility and molecular sizes...
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TASTE MASKING BY ION EXCHANGE RESIN AND ITS NEW APPLICATIONS: A REVIEW
More than 50% of pharmaceutical products are orally administered for several Reasons and undesirable taste is one of the important formulation problems that is Encountered with such oral products. Taste of a pharmaceutical product is an important parameter governing compliance. Hence taste masking of oral Pharmaceuticals has become important tool to improve patient compliance and the Quality of tr...
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NUTRITIONAL ASSESSMENT OF DIFFERENT PARTS OF ACACIA CATECHU WILLD. COLLECTED FROM CENTRAL INDIA
Acacia catechu is a multipurpose tree predominantly found in tropical and subtropical regions of India. The tree produces nitrogen rich fodder and green manure, high quality fuel wood and charcoal, strong durable poles and timber. The most useful products of this tree are Kutch or “Kattha” which is obtained from bark and heartwood of the tree. Commonly used plant part of Acacia catechu is bark...
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A COMPARATIVE STUDY OF THERAPEUTIC EFFECTS AND TOLERABILITY PROFILE OF CILNIDIPINE VERSUS AMLODIPINE IN MILD TO MODERATE ESSENTIAL HYPERTENSION
High Blood pressure or hypertension is one of the most ubiquitous yet nettle some medical problems that physician and health care provider face in the office. In present study amlodipine and cilnidipine have been selected to evaluate and compare their efficacy and tolerability in mild to moderate essential hypertension. 60 patients of uncomplicated mild to moderate essential hypertension were eval...
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PHARMACOGNOSTIC EVALUATION OF SUFOOF – E – HAZIM
Sufoof - e -Hazim (SEH), Unani formulation with high therapeutic efficacy, has been reported to cure indigestion and flatulence. The formulation is available with different manufacturers but scientific data on its pharmacognosy is lacking. Hence, the current research work is an attempt to standardize the formulation and establish quality control parameters in terms of its phytochemical and chromat...
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DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF GLYCOGEN SYNTHASE KINASE-3β INHIBITORS AS ANTIDIABETIC AGENTS
To synthesize structurally modified novel Glycogen Synthase Kinase-3βinhibitors to overcome insulin resistance in type 2 diabetes mellitus and to overcome associated health problems with reducing morbidity, mortality and economic costs of diabetes. Methods. Nineteen Phenylmethylene hydantoin analogs were designed and docked in the ATP binding site of GSK-3β by Molegro Virtual Docker 2006.1.5...
9218
1949
INVESTIGATING THE EFFECT OF MOLECULAR WEIGHT OF POLYVINYLPYRROLIDONE AND HYDROXYPROPYL METHYL CELLULOSE AS POTENTIAL ANTIPRECIPITANTS ON SUPERSATURATED DRUG SOLUTIONS AND FORMULATIONS USING WEAKLY ACIDIC DRUG: INDOMETHACIN
Most of the drug discovered in past decade belongs to biopharmaceutical classification system (BCS) class II. The solubility of these drugs is the limiting factor for oral bioavailability. The drug can be present in solution in a supersaturated state; however, it has a tendency to crystallize out. In this paper, we aim to study the effect of molecular weight of Polyvinylpyrrolidone (PVP) (PVP K12,...
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A REVIEW ON THE POTENTIAL USE OF BLACK GINGER FROM EASTERN INDIA
Kaempferia parviflora Wall. Ex Baker is commonly known as ‘black ginger’ which belongs to the family Zingiberaceae. These are mostly found in the subtropical and tropical areas of Asia. It bears various pharmacological properties such as anticancerous, anti-allergic, anti-inflammatory, antioxidant and antimicrobial. Upon the reports we reviewed the plant aromatic rhizomes contained important p...
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MIDAZOLAM SOLUBILITY ENHANCEMENT PRE-FORMULATION TECHNIQUES AT NASAL PHYSIOLOGICAL pH
Midazolam is used as short-acting pre-anesthetic benzodiazepine with solubility of <0.1mg/mL at neutral-pH, which increases considerably in acidic media. Midazolam commercial acidic aqueous parenteral formulation (pH~3.3) causes pain and inflammation at administration site, which induces low patient-compliance. According to the absence of non-parenteral formulation, available parenteral dosage-...
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CANCER CAUSES AND TREATMENTS
Cancer is a genetic disorder that results from genetic or epigenetic alterations in the somatic cells and has abnormal cell growth which may be spread to other body parts. In 2018, 18 million cancer was recorded globally in which 9.5 million cancer cases in men, 8.5 million cases in women, and 9.6 deaths were also recorded in the same year. The most spreading cancer globally is prostate, breast, l...
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