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TREATMENT OUTCOME OF TUBERCULOSIS PATIENTS ON DOTS THERAPY FOR CATEGORY 1 AND 2 AT DISTRICT TUBERCULOSIS CENTRE
Background: India is highest tuberculosis (TB) burden country accounting for approximately 20% of global TB burden. To tackle this problem, Revised National Tuberculosis Control Programme (RNTCP) based on the DOTS (Directly Observed Treatment Short course) strategy has been made available in the entire country by March 2006. Present study describes the achievements under RNTCP in terms of treatm...
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A REVIEW ON THE SYNTHESIS AND THERAPEUTIC POTENTIAL OF PYRIMIDINE DERIVATIVES
The chemistry of pyrimidine is a blossoming field. Numerous method for the synthesis of pyrimidine and also their diverse reactions offer enormous scope in the filed of medicinal chemistry. The utility of pyrimidines as synthon for various biologically active compounds has given impetus to these studies. The review article aims to review the work reported and the chemistry and biological activitie...
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FORMULATION AND EVALUATION OF TRANSDERMAL GEL OF LORNOXICAM AND ITS DELIVERY BY PASSIVE AND INOTOPHORESIS METHOD: A COMPARATIVE STUDY
The objective of present study was to develop Lornoxicam transdermal gel and its iontophoretic delivery to enhance its permeation for systemic effect and to avoid its side effects. Lornoxicam is a COX-1 and COX-2 inhibitor used in the treatment of inflammation, pain, edema and rheumatoid arthritis. Transdermal gel of Lornoxicam was formulated using triethanolamine as solvent, carbopol 934P as gel ...
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SOLUBILITY ENHANCEMENT OF POORLY WATER SOLUBLE PROTEASE INHIBITOR
There are more than 40% of drugs which are poorly soluble and 90% of the drugs from the pipeline are from BCS class II and IV. Application of techniques like computers, robotics, high-throughput screening, combinatorial chemistry have resulted in database of huge drug-like molecules which are generally derived solely based on the affinity of the molecule with the target physiological bodies viz....
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REGULATORY ASPECTS FOR IMPURITY PROFILING OF PHARMACEUTICAL PRODUCTS: AN OVERVIEW
Pharmaceutical impurities are the organic and inorganic unwanted chemicals which are found in active pharmaceutical ingredient after synthesis or develop during formulation development. These impurities severely affect the safety and efficacy of developed pharmaceutical product. Impurity profiling detects and quantifies the levels of organic and inorganic impurities and thereby helps in better mon...
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ANTIBACTERIAL ACTIVITY, PHYTOCHEMICAL SCREENING AND ANTIOXIDANT ACTIVITY OF STEM OF NICOTIANA TABACUM
The parts of the Nicotiana tabacum plant have been known to possess a wide range of biological activities. The purpose of the present study was to investigate the antibacterial activity, phytochemical screening and the antioxidant activity of aqueous and alcoholic extracts of the stem of Nicotiana tabacum. The antibacterial activity was observed against two gram positive bacteria (Bacillus amyloiq...
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FORMULATION DEVELOPMENT AND QUALITY PROFILING OF PARACETAMOL – IBUPROFEN COMBINATION TABLETS
Opportunity is envisaged by some astute pharmaceuticals manufacturers to increase product portfolio and widen the spectrum of treatment of pains to cover analgesia, pyrexia and inflammation using one product. In this research work, paracetamol – ibuprofen combination tablet was designed and formulated, developed and profiled to address this anticipation thus satisfying the requirement of one pro...
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DESIGN, FORMULATION AND EVALUATION OF BITTER LEAF TABLETS
Vernonia amygdalina, commonly called bitter leaf, is a perennial shrub that belongs to the family Asteraceae and grows throughout tropical Africa. Traditional medicine practitioners use the plant as in treatment of several disease conditions especially diabetes mellitus. In this research, the feasibility of tableting Vernonia amygdalina leaf was examined using three binders. Tableting of the leaf ...
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COMPARATIVE STUDY OF EFFECTS TWO β2 ADRENERGIC AGONISTS ON BIOCHEMICAL PARAMETERS IN MODERATE TO SEVERE BRONCHIAL ASTHMA PATIENTS
Background: β2- agonist drugs are frequently prescribed in asthmatics. Apart from bronchodilation they affect biochemical and physical parameters of the body. Method: Total 80 patients were divided into two groups. Group I (n=40) received Albuterol- 2.5mg./2.5ml. TDS and Group II (n=40) received Levalbuterol- 0.63mg./2.5ml, TDS via nebulizer for 4 weeks. Baseline and post-treatment estimatio...
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SUICIDE RISKS AMONG ADOLESCENTS: A LOOK BEHIND THE BLACK CURTAIN
This review article investigates the prevalent existence of suicide along with its risk factors and contributing factors leading to the culmination of them all, in an attempt to look behind the black curtain. Suicide is the result of an unbalanced scale between the good and bad. Every year 300,000 teenagers attempt and succeed at suicide worldwide. A set of emotions and unpleasant thoughts develop...
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