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THROMBOLYTIC & CYTOTOXIC EFFECT OF DIFFERENT HERBAL EXTRACTS
An in-vitro thrombolytic model was used to check the clot lysis effect of four herbal extracts viz., Honey, Nigella sativa, Capsicum frutescens, Brassica oleracea, combination of Honey & Nigella sativa and Honey & Capsicum frutescens along with Streptokinase as a positive control and water as a negative control. And also brine shrimp lethality bio-assay was done using brine shrimp Nauplii ...
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IN-VITRO ANTIOXIDANT AND CYTOTOXIC POTENTIAL OF HYDROMETHANOLIC EXTRACT OF AVERRHOA BILIMBI L. FRUITS
Averrhoa bilimbi Linn. (Family: Oxalidiaceae) is a medicinal plant which is extensively used in traditional medicine to cure cough, cold, itches, boils, rheumatism, syphilis, diabetes, whooping cough, and hypertension. In this study, hydromethanolic extract of A. bilimbi fruits was examined for its antioxidant action using 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging and total antioxid...
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EFFICACY AND MECHANISMS OF MEDICINAL PLANTS AS IMMUNOTHERAPY IN TREATMENT OF ALLERGIC RHINITIS: A SYSTEMATIC REVIEW
Allergic rhinitis is a common disease of immune system that negatively affects general health, quality of life, and social relationships. In the recent years, many studies have been conducted to discover novel treatments for this disease particularly using natural products. Here, we review findings of recent studies that harness medicinal plants and phyto-therapies in oriental medicine that have e...
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REGULATORY ASPECTS FOR IMPURITY PROFILING OF PHARMACEUTICAL PRODUCTS: AN OVERVIEW
Pharmaceutical impurities are the organic and inorganic unwanted chemicals which are found in active pharmaceutical ingredient after synthesis or develop during formulation development. These impurities severely affect the safety and efficacy of developed pharmaceutical product. Impurity profiling detects and quantifies the levels of organic and inorganic impurities and thereby helps in better mon...
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EVIDENCE BASED ANTI-DEMENTING ACTIVITY OF SARASWATA GHRITA “A NOOTROPIC COMPOUND FROM AYURVEDA
Life expectancy is increasing as a result of advancement in medical science and the availability of better healthcare services. As the risk of dementia increases with increasing age, the number of persons with dementia in the general population is also rising. Alzheimer’s disease is the most common form of dementia, accounting for approximately 70%...
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EVALUATION OF α-AMYLASE, α-GLUCOSIDASE AND ALDOSE REDUCTASE INHIBITORS IN ETHYL ACETATE EXTRACTS OF ENDOPHYTIC FUNGI ISOLATED FROM ANTI-DIABETIC MEDICINAL PLANTS
Twenty two endophytic fungi were isolated from anti-diabetic plants Momordica charantia and Trigonella foenum-graceum. Ethyl acetate extracts of all fungal isolates were tested for inhibition of aldose reductase and carbohydrate metabolizing enzymes. Ethyl acetate extracts of nine endophytic fungi were found to be positive for α- amylase and α- glucosidase inhibitors. Crude extracts of fungal is...
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RP-HPLC METHOD FOR SIMULTATANEOUS DETERMINATION OF AMLODIPINE BESYLATE, VALSARTAN, TELMISARTAN, HYDROCHLOROTHIAZIDE AND CHLORTHALIDONE: APPLICATION TO COMMERCIALLY AVAILABLE DRUG PRODUCTS
A simple, precise and stability-indicating HPLC method was developed and validated for the simultaneous determination of anti-hypertensive drugs Amlodipine Besylate, Valsartan, Telmisartan and diuretics Hydrochlorothiazide and Chlorthalidone. The separation was achieved on Cosmosil PAQ (150 mm × 4.6 mm) 5 μm column with gradient flow. The mobile phase at a flow rate of 1.0 mL min−1 cons...
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ANTIDIABETIC ACTIVITY OF PIPER BETLE IN ALLOXAN INDUCED TYPE 1 DIABETIC MODEL RATS
The aim of this study was to investigate the potential antidiabetic activity of Piper betle in alloxen induced diabetics. Rats were divided into 6 groups and Piper betle was administered containing 50, 100 and 200 mg/kgbwt powder, respectively in 1ml water orally in group A, B and C rats. Metformin (150 mg/kgbwt) used as a reference standard drug. Blood glucose (BG), triglycerides (TG), total chol...
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MODULATION OF TUMOUR NECROSIS FACTOR Α ATTENUATES NALOXONE-PRECIPITATED OPIOID WITHDRAWAL SYNDROME
The present study has been designed to investigate the effect of modulation of tumour necrosis α (TNF-α) on naloxone induced opioid withdrawal syndrome. Chronic morphine (5mg/kg,i.p) administration followed by a single injection of naloxone (8mg/kg, i.p) was used to precipitate opioid withdrawal syndrome in mice. Behavioral observations were made immediately after naloxone treatment. Withdrawa...
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PHARMACOLOGICAL OVERVIEW OF FREEZE DRIED ANDAMAN NONI (MORINDA CITRIFOLIA.L) AGAINST CANCER AND NEUROLOGICAL DISORDER
Noni (Morinda citrifolia) is one of the important traditional medicinal plants have been used by Polynesia over a period of 2000 years. Morinda citrifolia belongs to family Rubiaceae (Coffee family) which is an evergreen small sized tree, with glossy and deeply veined leaves found in tropical regions and islands of South Pacific, West Indies, India, Africa, and Australia. Noni fruit juice tradit...
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