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FORMULATION AND CHARACTERIZATION OF ACTIVATED CHARCOAL AND METRONIDAZOLE LAYERED TABLETS AND EVALUATION OF THE IN VIVO PERFORMANCE OF METRONIDAZOLE – ACTIVATED CHARCOAL FORMULATION IN SPRAGUE DAWLEY® RAT MODEL INFECTED WITH ESCHERICHIA COLI O157:H7
Background: Due to Escherichia coli O157:H7 bacteria’s peculiar biochemical characteristics it is considered an emerging pathogen. The aim of this study is to design, develop and evaluate the efficacy of a single formulation combining adsorptive and anti infective properties in the treatment of diarrhoea caused by Escherichia coli O157:H7 in an animal model....
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ETHOSOMES – A PROMISING WAY FOR TRANSDERMAL DRUG DELIVERY
One of the major advances in vesicle research was the finding that some modified vesicles possessed properties that allowed them to successfully deliver drugs in deeper layers of skin. Transdermal delivery is important because it is a noninvasive procedure for drug delivery. Further, problem of drug degradation by digestive enzymes after oral administration and discomfort associated with parentera...
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SYNTHESIS AND BIOEVALUATION OF KETOCONAZOLE THIOSEMICARBAZONE ANALOGUES
Ketoconazole (KTZ) is a synthetic antifungal drug used to prevent and treat fungal infections, especially in immunocompromised patients such as those with AIDS. Resistance to ketoconazole has been observed in a number of clinical fungal isolates, including C. albicans. Thus new effective agents with less toxicity against fungal infection are urgently required. With this view, ketoconazole thiosemi...
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LYOPHILIZATION CYCLE COMPARISON AND SCALE-UP OF ESOMEPRAZOLE SODIUM FOR INJECTION BETWEEN LAB SCALE AND SCALE-UP BATCHES VS FDM STUDY
Lyophilization also known as freeze drying is a process in which water is removed from a product after it was frozen and placed under a vacuum, allowing the ice to change directly from solid to vapor without passing through a liquid phase. The process consists of three separate, unique, and interdependent processes; freezing, primary drying (sublimation), and secondary drying (desorption...
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ANTIBIOTIC PRODUCTION BY RHIZOSPHERIC SOIL MICROFLORA – A REVIEW
The rhizosphere represents the thin layer of soil surrounding plant roots and the soil occupied by the roots, supports large active groups of microorganisms. The vast organic compounds (amino acids, sugars etc.) secreted by plant roots in the rhizosphere provide a food source for microorganisms increasing microbial biomass and their activity in the rhizosphere. Antibiotics are antimicrobial compou...
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PHARMACOLOGICAL POTENTIALS OF MORINGA OLEIFERA LAM.: A REVIEW
The aim of this literature review was to provide advance research information for the future scientists to discover new drug molecules from the medicinal plant, Moringa oleifera Lam. (Moringaceae). The plant provides a rich and rare combination of zeatin, quercetin, beta-sitosterol and kaempferol. In addition to its high nutritional value, Moringa oleifera Lam is very important for its medicina...
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EVALUATION OF CENTRAL AND PERIPHERAL ANALGESIC ACTIVITIES OF SOLANUM MELONGENA ETHANOLIC LEAF EXTRACT IN EXPERIMENTAL ANIMALS.
The aim of the study was to evaluate the central and peripheral analgesic activities of Solanum melongena ethanolic leaf extract in experimental animals. The Solanum melongena leaves were air dried at room temperature and were ground to a fine powder. Ethanolic extract was obtained by percolating the dried powder with 95% ethanol. Oral toxicity test was done according to OECD guidelines. For evalu...
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IN SITU GEL -SUSTAINED NASAL DRUG DELIVERY
In situ forming polymeric formulations are drug delivery systems that are in sol form before administration in the nasal cavity, but once administered, undergo gelation in situ, to form a gel. The formation of gel depends on factors like temperature modulation, pH change, presence of ions and ultra violet irradiation, from which the drug gets released in a sustained and controlled manner. In the r...
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FOLATE CONJUGATES: A BOON IN THE ANTI-CANCER THERAPEUTICS
Targeted delivery system is a promising strategy for improving cancer treatment and diagnostics. Molecular targeted drug delivery system has the potential to maximize the cancer treatment efficacy and minimize the toxicity to normal cells. Folate receptor (FR), an established ovarian cancer marker, is frequently found to be overexpressed in other major epithelial tumors. Overexpression of FR- β...
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IN-SITU OPHTHALMIC GELS FOR THE TREATMENT OF EYE DISEASES
Topical administration of a drug in the conjunctival cul-de-sac is the treatment of choice for diseases of the anterior segment of eye. Development of ophthalmic drug delivery systems has always been challenging because of the drawbacks with this route, like non-productive absorption, drainage, induced lacrimation, tear turn over, impermeability of drugs to cornea. New approaches have been investi...
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