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PENETRATION OF DICLOFENAC FROM NOVEL QUICK PENETRATING SOLUTION. A COMPARATIVE SCINTIGRAPHY STUDY WITH GEL
Topical NSAIDs do not effectively cross the skin due to barrier of stratum corneum. The aim of the study was to evaluate penetration of diclofenac from a novel quick penetrating solution (QPS) and conventional gel prepared using Tc-99 m labeled diclofenac. The study was conducted in 16 healthy subjects, divided in 4 groups, each with 4 subjects. In first three groups, the applications were made on...
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FORMULATION DEVELOPMENT USING MAIZE STARCH & AVICEL PH101 AS DISINTEGRATING AGENTS AND THEIR EFFECT ON PHYSICAL CHARACTERISTICS & IN VITRO RELEASE PROFILE
The present study was undertaken to formulate directly compressible tablets to investigate the effect of different disintegrating agents such as maize starch and avicel PH101 on disintegration time, in vitro drug dissolution and their release properties. Tablets of paracetamol and the combination of paracetamol and diclofenac using maize starch and avicel PH 101 were prepared separately by direct ...
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A NOVEL HPLC METHOD FOR THE SIMULTANEOUS DETERMINATION OF CHLORPHENIRAMINE MALEATE AND DEXTROMETHORPHAN IN BULK AND PHARMACEUTICAL FORMULATION
Chlorpheniramine maleate and Dextromethorphan are used in treatment of cough caused by allergies and the common cold by decreasing intra ocular pressure. The present study was designed to develop and validate a simple, sensitive, precise and accurate reverse phase high performance liquid chromatographic (HPLC) method for simultaneous determination of Chlorpheniramine maleate and Dextromethorphan i...
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THE VALUE OF DOXYCYCLINE IN ACETIC ACID INDUCE ULCERATIVE COLITIS IN RATS
Ulcerative colitis is an idiopathic chronic inflammatory disease of the colon for which a lot of treatment modalities are present, however, significant side effects are associated with them and there is a need for a search for other treatment options. This study was aimed to investigate the therapeutic role of Doxycycline in experimentally induced colitis in rats. Animals were categorized into 5...
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BUCCAL CONTROL DRUG DELIVERY SYSTEM: A REVIEW
Buccal controlled drug delivery system has been developed since the environment of the oral cavity provides potential sites for drug delivery. The acid hydrolysis and first pass effects can be avoided. The release of drug can be affected by continuous secretion of saliva. The mucin film exists in oral mucosa offers an opportunity to develop mucoadhesive system, which retain at absorption site for ...
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REACTIVE OXYGEN SPECIES (ROS) ARE BOON OR BANE
Reactive oxygen species (ROS) are inevitable by-products of cellular respiration. These are highly reactive chemical species derived from molecular oxygen (O2). These include the superoxide (O2−) and hydroxyl (HO−) free radicals as well as non-radical molecules such as hydrogen peroxide (H2O2). These act as both toxic and beneficial compounds, since they can be either harmful or helpful to the...
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METHOD DEVELOPMENT AND VALIDATION OF STABILITY INDICATING METHOD FOR ANALYSIS OF LOSARTAN POTASSIUM IN BULK DRUG AND DOSAGE FORM FORMULATION
Losartan potassium in tablet dosage form, separation achieved with C 18 column (Kromasil 100-5C18250mm x4.6mm E82860 i.d., 5µm particle), ambient temperature with isocratic mode with mobile phase containing 40:60 Acetonitrile: Buffer consist of 10.5mM of disodium hydrogen phosphate and 10mM potassium dihydrogen phosphate, pH 3.5 adjusted by 10 % Orthophosphoric acid and at flow rate 1.0ml/m...
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A PHARMACOLOGICAL AND TOXICOLOGICAL REVIEW OF LAWSONIA INERMIS
Herbal medicines are in great demand in the developed as well as developing countries for primary healthcare because of their wide biological and medicinal activities, higher safety margins and lesser costs. Lawsonia inermis L. is commonly known as Henna or Mhendi and abundantly available in tropical and subtropical areas. Henna belongs to lythraceae, also known as the loosestrife family. Ancient ...
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FORMULATION AND EVALUATION OF α-TOCOPHEROL ACETATE TABLET BY LIQUID-SOLID TECHNOLOGY
The objective of this research was to develop a liquisolid (LS) formulation of dl-α tocopherol acetate with improved dissolution properties and evaluate its strength to excipient modifications as well as its stability. Microcrystalline cellulose (MCC) and sodium starch glycolate (SSG) was employed as carrier material and disintegrant respectively for preparing LS compacts. Colloidal silicon dioxi...
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CLINICAL PHARMACIST INTERVENTIONS IN DRUG THERAPY IN PATIENTS WITH DIABETES MELLITUS AND HYPERTENSION IN A UNIVERSITY TEACHING HOSPITAL
Introduction: Drug related problems occur commonly in patients who often receive polypharmacy with multiple co-morbid conditions. This constitutes a major health problem because of their negative consequences with increased morbidity and mortality. Aims and Objectives: The aim of the study was to assess the impact of clinical pharmacist interventions in drug therapy in hospitalized diabetes mellit...
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