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DEVELOPMENT AND BIOEQUIVALENCE STUDY OF OLANZAPINE 10mg TABLETS
Generic drugs are lower-cost versions of patent-expired original brand-name medications. According to guidelines of regulatory agencies of the Canada, US and European Union, a generic drug must be “identical, or bioequivalent to a brand name drug in dosage form, safety, strength, route of administration, quality, performance characteristics and intended use”. Bioequivalence is decreed when the...
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PHYSICOTECHNICAL PROPERTIES OF PARACETAMOL TABLETS FORMULATED WITH THE GUM FROM THE FRESH LEAVES OF CORCHORUS OLITORIUS
Corchorus olitorius L. belongs to the family Tiliaceae. It is a plant with diverse medicinal uses. Its leaves when used to cook, give rise to a ‘slimy, viscous’ soup, hence the interest in investigating its binding properties. Gum was extracted from its leaves using standard procedures. The extracted gum was then used to prepare paracetamol tablets using concentrations of 1%, 2%, 4% and 6% res...
8553
1805
INDIAN NATURAL ZEOLITE CATALYZED SYNTHESIS OF β-AMINOHETERONAPTHOL AND THEIR POTENT ANTIMICROBIAL EFFICACY
A highly resourceful, elegant, simple and green technique with exceptionally facile reaction conditions of one pot three component reaction was applied to synthesized series of novel mannich base having an array of biologically and pharmaceutically active novel heterocycles. The present protocol offered a valuable alternative to known methods and will find applications in the field of green synthe...
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1615
EVALUATION OF DIURETIC EFFECT OF LYCIUM BARBARUM LINN. (GOJI BERRY) IN RATS
Wolf berries or Goji berries (Lycium barbarum L. Solanaceae) have a long tradition as food and medicinal plant. The bark of Goji berries is generally harvested in the winter season and then dried to be used for diuretic purposes. Hence, this study was designed to evaluate the possible diuretic effects of powdered L. barbarum. The study was conducted in saline primed Wistar albino rats (n=6) using ...
8544
1954
A FACTORIAL STUDY ON THE EFFECTS OF HYDROXYPROPYL β CYCLODEXTRIN AND POLOXAMER ON THE SOLUBILITY AND DISSOLUTION RATE OF NIMESULIDE
The objective of the study is to evaluate the individual and combined effects of hydroxy propyl β cyclodextrin (HPβCD), surfactant (Poloxamer 407) on the solubility and dissolution rate of nimesulide, a BCS class II drug in a series of 22 factorial experiments. The solubility of nimesulide in four selected fluids containing HPβCD and Poloxamer 407 as per a 22 factorial study was determined. HP...
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1567
RECENT TRENDS IN TREATMENT AND MANAGEMENT OF FILARIASIS
Filariasis is the name for a group of tropical diseases caused by various thread-like parasitic round worms (nematodes) and their larvae. The larvae transmit the disease to humans through a mosquito bite. Filariasis is characterized by fever, chills, headache, and skin lesions in the early stages and, if untreated, can progress to include gross enlargement of the limbs and genitalia in a condi...
8540
1942
A SYNERGISTIC APPROACH TO KINETIC AND MECHANISTIC STUDIES OF REGENERATION OF β-CAROTENE FROM TERT-BUTOXYL RADICAL INDUCED β-CAROTENE RADICAL CATION BY CHLOROGENIC ACID
The rates of oxidation of β-carotene and chlorogenic acid by tert-butoxyl radicals (t-BuO·) were studied by measuring the absorbance of β-carotene at 491 nm and chlorogenic acid at 328 nm spectrophotometrically. Radicals (t-BuO·) were generated by the photolysis of tert-butyl hydroperoxide (t-BuOOH) in presence of tert-butyl alcohol to scavenge OH·radicals. The rates and the quantum yields (f...
8534
1854
TRANSETHOSOMES: A NEW PROSPECT FOR ENHANCED TRANSDERMAL DELIVERY
The skin covers a total surface area of approximately 1.8 m2 and provides the contact between the human body and its external environment. Transdermal route of drug delivery has gained great interest in pharmaceutical research as it overcomes many problems associated with the oral route of administration. Although the skin, particularly the stratum corneum presents a barrier to most drug absorptio...
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3782
ETHOSOMES – A PROMISING WAY FOR TRANSDERMAL DRUG DELIVERY
One of the major advances in vesicle research was the finding that some modified vesicles possessed properties that allowed them to successfully deliver drugs in deeper layers of skin. Transdermal delivery is important because it is a noninvasive procedure for drug delivery. Further, problem of drug degradation by digestive enzymes after oral administration and discomfort associated with parentera...
8528
2460
EFFECT OF DIFFERENT WAVELENGTHS OF LIGHT ON THE GROWTH OF CHLORELLA PYRENOIDOSA
Chlorella pyrenoidosa is a fresh water microalgae used as substrate for production of value added products like biodiesel. In this investigation C.pyrenoidosa was grown for ten days in an internally illuminated bubble column photobioreactor at: 450 lux green light (495–570 nm), 480 lux red light (620–750 nm), 1663 lux blue light (450–495 nm), 1986 luxwhite light (380 to 750 nm).The results...
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2234