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SIMPLE AND RAPID SPECTROPHOTOMETRIC DETERMINATION OF ATENOLOL AND ESMOLOL β-BLOCKERS IN PHARMACEUTICAL FORMULATIONS AND SPIKED WATER SAMPLES
Atenolol and esmolol drugs belonging to a β–blocker group are frequently used for the treatment of cardiovascular diseases. These drugs are also charged as water pollutants. A new simple and rapid spectro-photometric method has been developed for their determination in pharmaceutical formulations and in spiked water samples. The proposed method is based on the derivatization of the amino functi...
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A STUDY TO EVALUATE THE IN VITRO ANTIMICROBIAL ACTIVITY AND ANTIANDROGENIC EFFECTS ON RATS OF Cr (III) COMPLEXES OF S∩N DONOR LIGANDS
The present paper deals with synthesis and characterization of some new chromium (III) Schiff base complexes using microwave irradiation technique as well as conventional heating. The S∩N donor benzothiazolines, 1-(2-furanyl) ethanone benzothiazoline (Bzt1N∩SH), 1-(2-thienyl) ethanone benzothiazoline (Bzt2N∩SH) and 1-(2-pyridyl) ethanone benzothiazoline (Bzt3N∩SH) were prepared by the cond...
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INVESTIGATION OF HEAVY METALS CONTENT IN SELECTED TEA BRANDS MARKETED IN PODGORICA, MONTENEGRO
Medicinal plants are sources of different chemical substances with different biological activities in living organism. Some of the chemical compounds so-called “heavy metals”, can be dangerous because they tend to bioaccumulate and transported in all biota via the food chain. The aim of our study was to investigate the concentration of heavy metals in commercially available tea samples purchas...
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A NOVEL OPHTHALMIC DRUG DELIVERY SYSTEM: IN-SITU GEL
The ophthalmic in-situ gels now days proved an palpable sustained drug delivery in various eye diseases. The formulation of in-situ gels for eye which carries the advantages like easy for administration, reduces frequency of dose and improves patient compliance. The formation of in-situ gels depends on phase transition system or sol-gel transition system. The formulation approaches like temperatur...
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ORPHAN DRUGS: OVERVIEW AND REGULATORY REVIEW PROCESS
Orphan drugs are medicines or vaccines intended to treat, prevent or diagnose a rare disease (viz., Huntington's disease, myoclonus disease, Tourette syndrome, etc.). The definition of rare diseases varies across jurisdictions but typically considers disease prevalence, severity, and existence of alternative therapeutic options. A rare disease is not universal and depends on the legislation and po...
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ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITIES OF THE LEAF EXTRACT OF BRASSICA NIGRA
Crude ethanolic extract of Brassica nigra was studied to detect the chemical compounds as well as to evaluate the antioxidant and anti-inflammatory activities. The different antioxidants assays including total antioxidant activity, DPPH, nitric oxide (NO) scavenging, reducing power, total phenolic content and flavonoid content were studied. Phytochemical screening showed the presence of alkaloids,...
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PHYTOCHEMICAL SCREENING AND DIURETIC ACTIVITY OF ALLIUM SATIVUM STEROIDAL AND TRITERPENOID SAPONIN FRACTION
Allium sativum L. (Liliacea) is a perennial bulb with a tall, erect flowering stem. The bulb of the plant has been used in many parts of the world as a stimulant, carminative, antiseptic, expectorant, anthelmintic and diuretic. This study has been planned to assess the diuretic activity of fresh garlic bulb extract targeting the steroidal and triterpenoidal saponin content. The rats were randomly ...
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PHARMACOLOGICAL POTENTIAL OF GREEN ALGAE CAULERPA: A REVIEW
From the beginning of civilization, humans depend on the natural products for their food and as medical treatment. Diversity in various bioactive compounds from marine organisms has been tested for the multiple pharmacological effects. Marine algae are surviving in a competitive environment with developed defense strategies and significant levels of chemical structural diversity with a wide variet...
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BUCCAL CONTROL DRUG DELIVERY SYSTEM: A REVIEW
Buccal controlled drug delivery system has been developed since the environment of the oral cavity provides potential sites for drug delivery. The acid hydrolysis and first pass effects can be avoided. The release of drug can be affected by continuous secretion of saliva. The mucin film exists in oral mucosa offers an opportunity to develop mucoadhesive system, which retain at absorption site for ...
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SYNERGISTIC PHARMACOLOGICAL EFFECTS OF PHYTOCHEMICALS DERIVED FROM GINGER, GARLIC AND TULSI
This review article is focused at highlighting the therapeutic values of phytochemicals derived from the natural herbs ginger, garlic and tulsi. It is shown that the phytochemicals derived from these natural herbs work synergistically and exert similar pharmacological profile. The main actions include antioxidant and anti-inflammatory properties. Recommendations are made to follow the antioxidant ...
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