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FOLATE CONJUGATES: A BOON IN THE ANTI-CANCER THERAPEUTICS
Targeted delivery system is a promising strategy for improving cancer treatment and diagnostics. Molecular targeted drug delivery system has the potential to maximize the cancer treatment efficacy and minimize the toxicity to normal cells. Folate receptor (FR), an established ovarian cancer marker, is frequently found to be overexpressed in other major epithelial tumors. Overexpression of FR- β...
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PHYTOCHEMICAL SCREENING AND DIURETIC ACTIVITY OF ALLIUM SATIVUM STEROIDAL AND TRITERPENOID SAPONIN FRACTION
Allium sativum L. (Liliacea) is a perennial bulb with a tall, erect flowering stem. The bulb of the plant has been used in many parts of the world as a stimulant, carminative, antiseptic, expectorant, anthelmintic and diuretic. This study has been planned to assess the diuretic activity of fresh garlic bulb extract targeting the steroidal and triterpenoidal saponin content. The rats were randomly ...
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PHARMACOLOGICAL POTENTIAL OF GREEN ALGAE CAULERPA: A REVIEW
From the beginning of civilization, humans depend on the natural products for their food and as medical treatment. Diversity in various bioactive compounds from marine organisms has been tested for the multiple pharmacological effects. Marine algae are surviving in a competitive environment with developed defense strategies and significant levels of chemical structural diversity with a wide variet...
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VARIANTS OF ORAL GLUCOSE TOLERANCE TEST (OGTT) CURVE IN GESTATIONAL DIABETES MELLITUS (GDM)
Objective: Gestational diabetes mellitus is defined as “carbohydrate intolerance resulting in hyperglycemia of variable severity with onset or first recognition during pregnancy, whether or not insulin is used and regardless of whether diabetes persists after pregnancy. There is evidence that asymptomatic hyperglycemia during pregnancy leads to important morbidity in the mother and foetus. Hence...
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DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR DETERMINATION OF LEVOFLOXACIN IN TABLET USING UV AND FLUORESCENCE DETECTORS SIMELTANIOUSLY
Simple, sensitive, precise, accurate, and specific reversed –phase high-performance liquid chromatography (RP-HPLC) method was developed and validated for the determination of levofloxacinin pharmaceutical tablets. Levofloxacin is a third generation fluoroquinolones with a wide spectrum of action against gram-positive and gram-negative bacteria, anaerobic microorganisms and atypical pathogens. I...
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PHYTOCHEMICAL SCREENING AND ANTIOXIDANT ACTIVITY OF LEUCAS ASPERA
The purpose of the current work was to conduct phytochemical screening and antioxidant activity of different extracts of Leucas aspera. The dried powder of the whole plant was extracted with n-hexane, ethyl acetate and ethanol which were subjected to various chemical tests to ascertain the main constituents of the plant. The results revealed the presence of significant amounts of alkaloids, glycos...
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ORPHAN DRUGS: OVERVIEW AND REGULATORY REVIEW PROCESS
Orphan drugs are medicines or vaccines intended to treat, prevent or diagnose a rare disease (viz., Huntington's disease, myoclonus disease, Tourette syndrome, etc.). The definition of rare diseases varies across jurisdictions but typically considers disease prevalence, severity, and existence of alternative therapeutic options. A rare disease is not universal and depends on the legislation and po...
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SYNERGISTIC PHARMACOLOGICAL EFFECTS OF PHYTOCHEMICALS DERIVED FROM GINGER, GARLIC AND TULSI
This review article is focused at highlighting the therapeutic values of phytochemicals derived from the natural herbs ginger, garlic and tulsi. It is shown that the phytochemicals derived from these natural herbs work synergistically and exert similar pharmacological profile. The main actions include antioxidant and anti-inflammatory properties. Recommendations are made to follow the antioxidant ...
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INVESTIGATION OF HEAVY METALS CONTENT IN SELECTED TEA BRANDS MARKETED IN PODGORICA, MONTENEGRO
Medicinal plants are sources of different chemical substances with different biological activities in living organism. Some of the chemical compounds so-called “heavy metals”, can be dangerous because they tend to bioaccumulate and transported in all biota via the food chain. The aim of our study was to investigate the concentration of heavy metals in commercially available tea samples purchas...
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FORMULATION AND CHARACTERIZATION OF ACTIVATED CHARCOAL AND METRONIDAZOLE LAYERED TABLETS AND EVALUATION OF THE IN VIVO PERFORMANCE OF METRONIDAZOLE – ACTIVATED CHARCOAL FORMULATION IN SPRAGUE DAWLEY® RAT MODEL INFECTED WITH ESCHERICHIA COLI O157:H7
Background: Due to Escherichia coli O157:H7 bacteria’s peculiar biochemical characteristics it is considered an emerging pathogen. The aim of this study is to design, develop and evaluate the efficacy of a single formulation combining adsorptive and anti infective properties in the treatment of diarrhoea caused by Escherichia coli O157:H7 in an animal model....
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