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VIROSOMES: A NOVEL VACCINATION TECHNOLOGY
Vaccine development has continuously shifted away from live attenuated or inactivated whole organisms. Although this approach having good efficacy but for improvement on comparison of risk/benefit ratio which needs improvement due to their highly complex compositions which result in safety concerns. As a consequence, a number of indications remained unadressed. The next generation vaccines represe...
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DEVELOPMENT AND VALIDATION OF ANALYTICAL METHOD FOR SIMULTANEOUS ESTIMATION OF MIGLITOL AND METFORMIN HYDROCHLORIDE IN TABLET DOSAGE FORM.
A simple, rapid and precise stability indicating reverse phase high performance liquid chromatographic method has been developed for simultaneous estimation of Miglitol and Metformine Hydrochloride in their tablet dosage form. Chromatography was performed on a Phenomenex ODS C18 (250 X 4.6 mm) 5mm column using Water: Methanol (50:50, v/v) pH: 4 mixture as a mobile phase. The detection was carried ...
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SIMULTANEOUS ESTIMATION OF PARACETAMOL, GUAIPHENSIN, PHENYLEPHRINE HCl, CHLORPHENIRAMINE MALEATE AND BROMOHEXINE HCl IN COMBINED TABLET DOSAGE FORM BY REVERSE PHASE HIGH PERFORMANCE LIQUID CHROMATO-GRAPHY
A reverse phase high performance liquid chromatographic method was developed for the estimation of paracetamol, guaiphenesin, phenylephrine HCl, chlorpheniramine maleate and bromhexine HCL in a single tablet dosage form. This method was proved to be simple, accurate, precise and robust. The chromatographic separation was achieved on a symmetry C-8 column with dimensions of 150 X 4.6mm, 3.5µm. All...
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ASSESMENT OF PHYTOCHEMICALS AND ANTIOXIDANT ACTIVITY OF MURRAYA KOENIGII LINN.
Objective: To analyze phytochemicals both qualitatively and quantitatively and to estimate in vitro antioxidant activity, total phenolic content and concentration of flavonoids of methanolic extract of leaf, stem and fruit of an important medicinal plant Murraya koenigii Linn. Methods: Phytochemical screening of extracts was carried out. Aluminium chloride colorimetric method was used to estimate ...
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ACID NEUTRALIZATION CAPACITY AND COST EFFECTIVENESS OF ANTACID SUSPENSIONS SOLD ACROSS VARIOUS RETAIL PHARMACIES IN VIJAYAWADA
Antacids are the commonly prescribed drugs for treating gastroesophageal reflux disease (GERD). As these are manufactured and marketed by various multinational and local companies there is a need for evaluating the cost effectiveness and efficacy of these antacids as a matter of public concern. In the present study an attempt has been made to determine and compare the acid neutralization capacity ...
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A FACTORIAL STUDY ON THE EFFECTS OF HYDROXYPROPYL β CYCLODEXTRIN AND POLOXAMER ON THE SOLUBILITY AND DISSOLUTION RATE OF NIMESULIDE
The objective of the study is to evaluate the individual and combined effects of hydroxy propyl β cyclodextrin (HPβCD), surfactant (Poloxamer 407) on the solubility and dissolution rate of nimesulide, a BCS class II drug in a series of 22 factorial experiments. The solubility of nimesulide in four selected fluids containing HPβCD and Poloxamer 407 as per a 22 factorial study was determined. HPÎ...
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QSAR STUDIES & DESIGNING OF POTENT HETEROCYCLIC COMPOUNDS AS γ-SECRETASE INHIBITORS
Quantitative structure activity relationship (QSAR) studies ware performed on series of structurally similar heterocyclic sulfonamide with enzyme gamma secretase inhibitor activity. The compounds were divided into training and test set and generated different QSAR models using V-Life MDS 3.5 software multiple linear regression (MLR) method. Best QSAR models were selected on the basis of various st...
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EVALUATION OF ANTIMICROBIAL ACTIVITY OF ASAFOETIDA
This study was carried out with the objective of the antibacterial and antifungal activity of chloroform, ethyl acetate, ethanol, methanol and aqueous extracts of Asafoetida. Antibacterial activity was carried out against Bacillus subtilis, Staphylococcus aureus, Klebsiella pneumonia, Escherichia coli and the antifungal activity was evaluated against Aspergillus niger, Candida albicans. The testin...
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PHYSICAL METHODS FOR ENHANCEMENT OF TRANSDERMAL DRUG DELIVERY IN PAIN MANAGEMENT
Pain is the major symptom associated with many diseases and disorders. Whether acute or chronic, pain causes much distress to the patient and can be debilitating in many cases. The quest for safe and effective pain management has driven the research efforts of the scientists for several decades. These ongoing efforts to come up with optimum therapeutic systems to deliver pain relief medication hav...
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PHYTOTHERAPY IN FUNGI AND FUNGAL DISEASE: A REVIEW OF EFFECTIVE MEDICINAL PLANTS ON IMPORTANT FUNGAL STRAINS AND DISEASES
Infectious diseases are among the most important common diseases worldwide that bring stupendous costs for human community. Medicinal plants are considered a rich source of antimicrobial agents and therefore can be used as antimicrobial remedies because of producing secondary metabolites. This article was designed to review the effective medicinal plants on fungi and fungal disease. In this study,...
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