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HECKEL AND KAWAKITA ANALYSES OF GRANULES OF THE CRUDE LEAVES EXTRACT OF VERNONIA GALAMENSIS PREPARED USING GELATIN AS BINDER
The powdered leaf of Vernonia galamensis (Asteraceae) is a herbal drug used in the treatment of diabetes mellitus in folk medicine in northern Nigeria. The crude aqueous extract of the leaves is deliquescent and usually stored in airtight desiccators. Efforts to use common diluents such as lactose, starch, and magnesium carbonate for tablet formulation of the extract produced tablets with defects ...
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1790
EXTRACTION, ISOLATION AND CHEMICAL STRUCTURE ELUCIDATION OF DAIDZEIN FROM BARK OF ACACIA ARABICA (LAM.) WILLD OF BHOPAL, MADHYA PRADESH, INDIA
Purpose: To extract, isolate and identify daidzein from the bark of Acacia Arabica (Lam.) Willd of Bhopal, Madhya Pradesh, India. Methods: Succesesive methanolic extract from the bark of Acacia arabica was subjected to column chromatography and fractionated by benzene, n-butanol, and acetone successively. Eluents having similar Rf values were pooled together. These pools were subjected to flavonoi...
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3031
COUNTERFEIT (FAKE) DRUGS & NEW TECHNOLOGIES TO IDENTIFY IT IN INDIA
A counterfeit medicine is one which is deliberately and fraudulently mislabeled with respect to identity or source. Counterfeiting apply to both branded and generic product which include products with the wrong ingredients, without active ingredients, with insufficient active ingredients. According to WHO, 25% of medicines consumed in poor countries could be counterfeit or below standard.An estima...
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1618
BINGERVONE, AN ANTIPROTOZOAL β-TRIKETONE DERIVATIVE FROM THE ROOTS OF UVARIA AFZELII (ANNONACEAE)
Uvaria afzelii Scott Elliot (Annonaceae) is an African traditional medicinal plant. In Ivory Coast, roots of the plant are commonly used as antiparasitic and against others ailments. During our previous investigation on the roots one 1-indanone derivative was obtained together with other compounds that showing interesting antiprotozoal activities. The aim of this study was to isolate other antipro...
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1593
A DETAILED REVIEW ON NANOEMULSION DRUG DELIVERY SYSTEM
Nanoemulsions are submicron sized emulsions that are under investigation as drug carriers for improving the delivery of therapeutic agents. These are the thermodynamically stable isotropic system in which two immiscible liquids are mixed to form a single phase by means of appropriate surfactant and cosurfactant. Nanoemulsion droplet sizes fall typically in the range of 20-200nm and shows narrow si...
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SYNTHESIS, CHARACTERIZATION, ANTIMICROBIAL AND PESTICIDAL ACTIVITY OF ORGANOARSENIC(III) AND ORGANOANTIMONY(III) COMPLEXES WITH N∩S DONOR LIGANDS
Some new Sb(III) and As(III) complexes of N∩S donor ligands N’-[1-(2-oxo-2H-chrome-3yl-ethylidene] - hydrazinecarbodithionic acid methyl ester (L1H) and N’ - [1-(2-oxo-2H-chrome-3yl - ethylidene] -hydrazinecarbodithionic acid benzyl ester (L2H) have been synthesized. All the synthesized compounds were characterized by elemental analyses, melting point determinations and a combinati...
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1507
MOLECULAR DOCKING STUDY OF ACYCLOVIR AND ITS DERIVATIVES AS POTENT INHIBITORS IN NOVEL COVID-19
Novel coronavirus (nCovid-19) is a recent emerging, dangerous pathogen that has shaken the whole world. Present therapeutic strategies to deals with this infectious disease are only supportive. The discovery of a new drug within a short period of time is a great task. Structure predictions of several proteins associated with SARS-CoV-2, the virus that causes COVID-19, was made possible by Genomics...
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FORMULATION AND CHARACTERIZATION OF A TRADITIONAL UNANI FORMULATION: KUSHTA QALAI
Kushta literally means burning of drugs of metallic, mineral or animal origin into their ash. Qalai (tin) based Unani compound formulation Kushta qalai (KQ) is used since antiquity for the treatment of various ailments. Although it is used on consistent basis by Hakims but at present there are no scientific data available about its quality control parameters. So, in this research article an emphas...
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1439
A STUDY ON THE ANTIMICROBIAL PROPERTY OF THE COTTON FABRIC IMPARTED WITH MICHAELIA CHAMPACA LEAF EXTRACT LOADED NANOPARTICLES
In the present work ethanol, methanol, ethyl acetate, chloroform and benzene extract of the Michaelia champaca leaves were screened for their antimicrobial activity. The ethanolic extracts of M. champaca leaves were proved to have the maximum antimicrobial activity; thus the ethanolic leaf extract was selected and the nanoparticles were synthesized using ionic gelification method. The nanopartic...
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1816
DEVELOPMENT AND VALIDATION OF ANALYTICAL METHOD FOR SIMULTANEOUS DETERMINATION OF MINOXIDIL AND FINASTERIDE IN PHARMACEUTICAL DOSAGE FORM BY RP-HPLC METHOD
A simple, precise, rapid, accurate RP-HPLC method has been developed and validated for the simultaneous determination of Minoxidil and Finasteride in pharmaceutical dosage form. The chromatographic separation was achieved on ODS C18 column (25 cm × 4.6 mm, 5 µ particle size) using a mobile phase comprising methanol: water along with 0.5 % triethyl amine (TEA), pH 6.38 adjusted with ortho phospho...
7640
1924