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BIOCHEMICAL MECHANISMS OF ETOPOSIDE; UPSHOT OF CELL DEATH
Etoposide is an antineoplastic agent employed for healingvarious malignancies in human. It is a semi-synthetic derivative of podophyllotoxin and was introduced in 1971. The primary mode of action of etoposide is the inhibition of the function of the enzyme topoisomerase II. It stabilizes DNA-enzyme complex, and accumulation of this complex enhances the probability of double-stranded DNA breaks. Ho...
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DERMATOPHYTOSIS: INFECTION AND PREVENTION -A REVIEW
The growing impact of infections caused by dermatophytes i.e. Trichophyton, Microsporum and Epidermophyton is not upto the mark in their treatments via conventional methods due to resistance, side effects, and high toxicity. Over prescription and overuse of traditional antifungal agents, high side effects, less eco-friendly nature, high manufacturing costs, high management costs etc., have stimula...
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A COMPREHENSIVE REVIEW ON COSTUS PICTUS D. DON
Costus pictus is rhizomatous medicinal herb, commonly known as “Insulin plant,” well known for its therapeutic properties. Many important and beneficial aspects of C. pictus are reported, which includes anti-diabetic, anti-microbial, anti-cancer, anti-oxidant, anti-fertility, anti-helminthic, diuretic, anti-inflammatory properties. The present review focus on the literature survey based on the...
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ANTIFERTILITY EFFECT OF AQUEOUS EXTRACT OF INDIGOFERA TRIFOLIATA LEAVES ON REPRODUCTIVE ABILITIES OF FEMALE ALBINO RATS
The present work deals with antifertility effect of the aqueous extract of Indigofera trifoliata leaves in female albino rats. Pregnant rats weighing 120 to 200 gm were randomized into 4 groups. From day 11 upto day 15 of pregnancy, rats were laprotomised on 10th day of pregnancy and live fetuses were observed in both the horns of the uterus. Rats in group 1 (control) were orally administered, wit...
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BIOACTIVITY OF MORUS ALBA L. EXTRACTS-AN OVERVIEW
Recently white mulberry has attracted a lot of interest as source of bioactive constituents used in phytopharmacy and in functional food formulation. In practice, active compounds are separated from plant material by extraction process using different solvents and extraction conditions. The most commonly solvents used for extraction are water, ethanol, methanol, acetone, ether and their mixtures. ...
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GOLDEN EYE GRASS – A MAGICAL REMEDY BY NATURE
From the dawn of civilization, medicinal plants are known to be part of human society to combat diseases. In recent times, focus on plant research has increased all over the world and various evidences have been collected to show immense potential of medicinal plants used in various traditional systems. India officially recognizes over 3000 plants for their medicinal value. It is generally estimat...
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STUDIES ON AN ANTI-AGING FORMULATION PREPARED USING ALOE VERA BLENDED COLLAGEN AND CHITOSAN
Photochemoprotection has nowadays become inevitable to combat aging. Exposure to Ultraviolet radiations accelerates skin aging which eventually culminates in wrinkles, laxity, dyspigmentation, roughness and dryness. Though many active synthetic topicals have been used since years, the present era of treating an aged skin has been diverted towards natural biomaterials as these synthetic topicals po...
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HISTAMINE SUBTYPE 3 RECEPTOR ANTAGONISTS: CURRENT STATUS WITH FUTURE PROSPECTS IN DRUG DISCOVERY AND DRUG DEVELOPMENT
The histamine H3 receptor is an G protein-coupled receptor that regulates neurotransmission in the central nervous system and plays a major role in cognitive and homeostatic functions. The third histamine receptor was discovered in 1983 by a traditional pharmacological approach, consisting of assessing the inhibitory effect of histamine on its own release from depolarized rat...
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MUCOADHESIVE BUCCAL DRUG DELIVERY SYSTEM: A REVIEW
As an alternative to injection pharmaceutical researcher and scientist are trying to explore transdermal and transmucosal route over the last few years. To overcome the deficiency associated with the other route of administration buccal region of oral cavity is an alternative target for the administration of choice of drug. The disadvantages relative with the oral drug delivery is the extensive pr...
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EVALUATION OF α – AMYLASE INHIBITORY ACTIVITY OF SOME CLINICALLY USED DRUGS
Finding out the alternative uses of the clinically proven and time tested drugs can be one of the best options for drug discovery research. In view of this the present study was carried out to evaluate α-amylase inhibitory activity of the some of the commonly used drugs. The drugs were procured as gift samples from pharmaceutical companies and were evaluated for in-vitro α-amylase inhibitory act...
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