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PHARMACOGNOSTIC EVALUATION AND ANTIMICROBIAL STUDIES ON MORINGA OLEIFERA LAM. (MORINGACEAE)
The pharmacognostic evaluation, anatomy and antimicrobial potentials of the leaf, stem and root of Moringa oleifera Lam were evaluated. Powdered extracts obtained from the various plant organs were used for the analytical standardization. The methanolic plant extracts were assayed for antimicrobial activities using the Agar well diffusion method. This was compared with standard antibiotics, Gentam...
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TRANSDERMAL DRUG DELIVERY SYSTEM (TDDS): AN OVERVIEW
The transdermal route of drug delivery has attracted researchers due to many biomedical advantages associated with it. However, excellent impervious nature of skin is the greatest challenge that has to be overcome for successfully delivering drug molecules to the systemic circulation by this route. This review describes enhancement techniques based on drug/vehicle optimization such as physical and...
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JASMINUM GRANDIFLORUM LINN. – AN UPDATE REVIEW
Plants form the basis of human and animal life. Plants are better choice for medicinal applications when compared to synthetic chemicals and the nature has provided various types of medicinal plants. Jasminum grandiflorum Linn. (family Oleaceae) is a night bloomy flowering plant and is an important source of methyl jasmonates which find utility in plant defense, fruit ripening, plant growth senesc...
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ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF SALBUTAMOL SULPHATE, GUAIFENESIN, AND AMBROXOL HYDROCHLORIDE BY RP-HPLC METHOD IN COMMERCIAL ORAL LIQUID DOSAGE FORM
Salbutamol is a bronchodilator, Guaifenesin is an expectorant and Ambroxol is a mucolytic. Combination of these drugs is used in the formulation of cough syrups. In the literature, there is no method reported for the simultaneous estimation of the drugs in oral liquid dosage form. Hence, the present work is aimed to develop reverse phase HPLC method for the simultaneous determination of Salbutamol...
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STUDY OF PRESCRIBED DOSE CALCULATION IN PEDIATRIC PATIENTS
Background: Pediatrics pose a unique set of risks of medication errors, predominantly because of the need to make dosage calculations, which are individually based on the patient’s weight, age or body surface area (BSA), and their condition. This increases the likelihood of errors, particularly dosing errors. In particular; preventing dosing errors is an important part of ensuring safe and quali...
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CORRELATION OF MINIMUM INHIBITORY CONCENTRATION OF CIPROFLOXACIN TO THE THERAPEUTIC RESPONSE OF PATIENT WITH URINARY TRACT INFECTION CAUSED BY ESCHERICHIA COLI
The choice of an antibiotic depends solely on the identification of the species by determination of the sensitivity characteristics of the microorganism. Along with the determination of sensitivity pattern, understanding the susceptibility pattern of particular strain isolated from patient is equally important. Variation in patient and microorganism is known to be key factor for predicting the out...
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BINGERVONE, AN ANTIPROTOZOAL β-TRIKETONE DERIVATIVE FROM THE ROOTS OF UVARIA AFZELII (ANNONACEAE)
Uvaria afzelii Scott Elliot (Annonaceae) is an African traditional medicinal plant. In Ivory Coast, roots of the plant are commonly used as antiparasitic and against others ailments. During our previous investigation on the roots one 1-indanone derivative was obtained together with other compounds that showing interesting antiprotozoal activities. The aim of this study was to isolate other antipro...
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LIQUISOLID TECHNIQUE: A REVIEW
Dissolution of drug and its release from the dosage form have basic impact on bioavailability. Bioavailability depends on solubility of drug. Solubility is major challenge for the pharmaceutical industry with the developments of new pharmaceutical products. There are several approaches for solubility enhancement which includes micronization, Nanonisation, use of salt forms, use of surfactant, soli...
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ORAL DISINTEGRATING TABLETS OF CILOSTAZOL-HP-β-CD INCLUSION COMPLEX
Low solubility and biovariability associated with cilostazol (CLZ) pose serious formulation problems despite several advancements in dosage form design. The present research work amalgamates two different solubility enhancement techniques, viz. spray drying and cyclodextrin inclusion complexation to produce amorphous composites of CLZ with increased solubility and dissolution characteristics. FTIR...
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STRATEGIES FOR ENHANCEMENT OF BIOAVAILABILITY OF MEDICINAL AGENTS WITH NATURAL PRODUCTS
In Advances drug design technologies, a large no of drug molecules are being introduced in every year but many of these molecules have problems like their solubility, stability, bioavailability and its long lasting side effects. Low bioavailability is one of the serious but curable problems in case of the drug molecule. Low bioavailability happens because a lot of molecules unable to permeation th...
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