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A COMPARATIVE STUDY OF THERAPEUTIC EFFECTS AND TOLERABILITY PROFILE OF CILNIDIPINE VERSUS AMLODIPINE IN MILD TO MODERATE ESSENTIAL HYPERTENSION
High Blood pressure or hypertension is one of the most ubiquitous yet nettle some medical problems that physician and health care provider face in the office. In present study amlodipine and cilnidipine have been selected to evaluate and compare their efficacy and tolerability in mild to moderate essential hypertension. 60 patients of uncomplicated mild to moderate essential hypertension were eval...
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PHYSICO-CHEMICAL AND PHARMACOLOGICAL PROSPECTIVE OF ROGHAN-E-NARJEEL (COCONUT OIL)
Roghan-e-Narjeel (coconut oil) is extracted from dried Maghz-e-Narjeel (coconut kernels) which is derived from coconut (Cocosnucifera L.) tree. It is used extensively in tropical countries especially India, Srilanka and Philippines. The oil contains 92% of saturates consisting of medium chain fatty acids in the form of triglycerides containing lauric acid in large amount, and about 8% of unsaturat...
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PHYTOTHERAPY IN THE TREATMENT OF ARTHRITIS: A REVIEW
As the conventional treatment is associated with large number of side effects, herbal treatment is gaining popularity particularly in the treatment of chronic disease like jaundice, vitiligo, rheumatoid arthritis, asthma etc. Herbal treatment has been identified as safe and effective in treating such disease. The aim of this study was to review systematically the evidences and effectiveness of her...
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MICROBIAL L-ASPARAGINASE: A REVIEW ON CURRENT SCENARIO AND FUTURE PROSPECTS
L-Asparaginase (E.C. 3.5.1.1.), also known as L-asparagine amidohydrolase is the enzyme with anti-tumor activity and is well accepted as a chemotherapeutic agent against the acute lymphoblastic leukemia and lymphosarcoma. This article has briefly touched nearly all the industrial and clinical aspects of L-Asparaginase and provides the recent update of the topic. The article includes a brief introd...
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VALIDATED UV SPECTROSCOPIC METHOD FOR ESTIMATION OF MONTELUKAST SODIUM
Montelukast sodium is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies1-2. Montelukast comes as a tablet, a chewable tablet, and granules to take by mouth3. Montelukast is usually taken once a day with or without food3. The present study describes a simple, accurate reproducible and precise uv spectrophotometric met...
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METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF LAMIVUDINE, TENOFOVIR AND EFAVIRENZ IN COMBINED TABLET DOSAGE FORM BY RP-HPLC AND UV-SPECTROSCOPIC METHOD
A rapid and sensitive RP-HPLC method with UV detection and UV spectrophotometric method for the determination of Lamivudine, Tenofovir and Efavirenz simultaneously in combined tablet dosage form was developed. Chromatography was performed with mobile phase containing a mixture of methanol: Water (pH adjusted to 2.5) and 0.1 % TEA in the proportion of (68: 32 % v/v) the samples were injected onto S...
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STUDY OF MEDICINAL PLANTS USED IN THE MANAGEMENT OF CARDIOVASCULAR DISEASES AT LIBREVILLE (GABON): AN ETHNOPHARMACOLOGICAL APPROACH
This work was conducted at a Libreville herbal market located in Peyrie in order to inventory plants used by people for the management of cardiovascular diseases such as hypertension and to evaluate their pharmacological effects. The method of preparation and modes of administration were also recorded. Twenty nine herbalists were interviewed using questionnaires. Twenty two plant species belonging...
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EFFICACY OF MUNZIJ WA MUSHIL-E-BALGHAM (POLY HERBAL FORMULATIONS) AND MASSAGE WITH ROGHAN-E-MALKANGANI IN FALIJ NISFI (HEMIPLEGIA): A RANDOMISED CONTROLLED CLINICAL TRIAL
This study was conducted as a single blind, randomized and standard controlled clinical trial in cases of Falij Nisfi (Hemiplegia) due to ischaemic stroke. Forty eligible patients of Hemiplegia were randomized into test and control groups, comprising 20 patients in each. Test group was given Nuskha munzije balghamfor12 days, followed byNuskha Mushile Balgham, mixed with Munzije Balgham for next ...
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SYNTHESIS AND CHARACTERISATION OF IBUPROFEN, KETOPROFEN PRODRUG FOR TASTE MASKING USING β- CYCLODEXTRIN
The Profens have indicated the gastrointestinal side effects due to the acidic moiety of the profen. The Profens are bitter in taste and it is omitted by mostly children. Therefore an attempt has been made to prepare the ester Prodrug using ethyl alcohol and butyl alcohol and its bitter taste is masked by using β-Cyclodextrin. The prepared prodrugs are characterised by melting point, UV and IR sp...
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ONLINE AND OFFLINE TOOLS: CRISPR/CAS OFF-TARGET DETECTION
Genome engineering field is a new revolution in biological research and to this new field several restriction endonucleases are available. Out of all these, based on easier construction, sensitivity and specificity Clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) preferred by scientists for research and industrial purposes. However, off-target DNA clea...
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