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OPTIMIZATION OF TELMISARTAN TABLET FORMULATION BY 23 FACTORIAL DESIGN EMPLOYING βCD, PRIMOJEL AND TWEEN 80
The objective of the present study is optimization of telmisartan tablet formulation employing βCD, Primojel, and Tween 80 by 23 factorial design to achieve NLT 85% dissolution in 10 min. Eight telmisartan tablet formulations were prepared using selected combinations of the three factors as per 23 factorial design. Telmisartan tablets were prepared by direct compression method and were evaluated....
12170
1923
FORMULATION AND EVALUATION OF IMMEDIATE RELEASE TABLET OF VALSARTAN
The immediate release tablet of antihypertensive drug Valsartan were prepared and evaluated to increase solubility and bioavailability of low soluble drug. The tablets were prepared by direct compression method using Surfactants such as Poloxamer 188, Sodium stearate, Sodium Lauryl Sulfate and Superdisintegrant such as Cross carmellose sodium were used in tablet formulation. The formulation were e...
12117
3817
CONSUMPTION OF UNMODIFIED COW’S MILK AND THE RISK OF IRON DEFICIENCY ANEMIA IN INFANTS AND TODDLERS AND ITS MANAGEMENT
Early introduction of complementary foods (weaning) before 4 to 6 months of age and unmodified cow’s milk before age 12 months are associated with several health risks in children. Too early introduction of unmodified cow’s milk and milk products to infants and toddlers has adverse effects on their iron stores. Children can develop iron-deficiency anemia from chronic enteric blood loss even wh...
12089
1949
A COMPARATIVE STUDY ON ANTIBACTERIAL ACTIVITIES AND CYTOTOXIC PROPERTEIS OF VARIOUS LEAVES EXTRACTS OF AVERRHOA BILIMBI
The study was carried out to assess the antibacterial & cytotoxic activities of extracts from leaf parts of the plant, Averrhoa bilimbi. Ethanol, methanol and water were used as solvents and antibacterial & cytotoxic effects were measured using disc diffusion test & brine shrimp lethality bioassay (BSLB). The susceptibility of the microorganisms to the extracts of this plant was compar...
12083
3206
A REVIEW ON PHARMACOGNOSY, PHYTOCHEMISTRY AND PHARMACOLOGICAL ACTIVITY OF CARICA PAPAYA (LINN.) LEAF
Papaya (Carica papaya Linn.) is well known for its nutritional as well as medicinal value since long time. The medicinal properties of fruit and other parts of papaya are well known in the different system of traditional medicine including Ayurveda. Its various parts has been reported for various disease conditions viz. fever, swellings, jaundice, gonorrhea, bilious fever, itches, eczema, and rheu...
12068
4204
ANTIBACTERIAL ACTIVITY OF RICINUS COMMUNIS LEAF EXTRACT
Based on the scope given by traditional knowledge, present study was conducted. The aim of the present study was to evaluate the antibacterial activity of castor (Ricinus communis, Family: Euphorbiaceae) leaf extract using five bacteria; two Gram-positive bacteria (Bacillus subtilis and Staphylococcus aureus) and three Gram-negative bacteria (Escherichia coli, Proteus vulgaris, Pseudomonas aerug...
12063
2713
QUANTIFICATION OF CHLORHEXIDINE GLUCONATE FROM MOUTH RINSE AND SKIN DISINFECTANT SOLUTIONS USING A VAIDATED CHROMATOGRAPHIC TECHNIQUE
The study presents a simple and rapid chromatographic technique for the estimation of chlorhexidine gluconate for mouth wash using a combination of phosphate buffer and acetonitrile as mobile phase. The separation was carried out on a stainless steel column 250mm × 4.5mm packed with octadecyle silane particles. The detection was carried out using a dual lambda absorbance detector at 254nm wavelen...
12032
2779
SELF MICROEMULSIFYING DRUG DELIVERY SYSTEM: A LIPID BASED DRUG DELIVERY SYSTEM
Administration of drug by oral route is the most effective and acceptable route as it has better therapeutic efficacy, low cost and good patient compliance. More than 40% of new drugs are poorly water soluble. These drugs present development challenges and also have poor bioavailability. Although many formulation approaches like solid dispersions, complexation, pH modification exist, novel lipid b...
12015
3467
IN VITRO ANTICANCER ACTIVITY AND PHYTOCHEMICAL ANALYSIS OF BACOPA MONNIERI (L.) WETTST.
Plants have played a significant role in the treatment of cancer and infectious diseases for the last many decades. Natural products have been rediscovered as important tools for drug development despite advances in combinatorial chemistry. Bacopa monnieri (L.) Wettst. (Scrophulariaceae) is a herbaceous plant traditionally used from time immemorial in Ayurvedic and folklore medicines. The various ...
11996
3687
A REVIEW: ROLE OF DOXORUBICIN IN TREATMENT OF CANCER
Cancer is a very complex genetic disorder that is mainly caused by carcinogens. Carcinogens can be present in the air, water, food, chemicals, and sunlight that are exposed to the people. In the case of leukemia, the body produces large numbers of abnormal white blood cells. In the study of blood cancer that is leukemia, blood disorders through visual inspection of microscopic images of blood cell...
11991
2994