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PROTECTIVE EFFECT OF POLYHERBAL SIDDHA FORMULATION-NILAVEMBU KUDINEER AGAINST COMMON VIRAL FEVERS INCLUDING DENGUE – A CASE-CONTROL APPROACH
Nilavembu Kudineer, a Siddha Polyherbal formulation, is a decoction concentrate widely used in Siddha Medicine to combat major type(s) of fevers including viral origin such as Dengue. Methodology: Study type: Prospective case-control with Retrospective data collection. Study Setting: National Institute of Siddha – it is a central Government Siddha Hospital, located at Chennai, Tamil Nadu and con...
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SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF NOVEL α-AMINOPHOSPHONATES BEARING A QUINOLINE MOIETY
A novel aminophenylaminoquinoline analogues have been synthesized starting from 4,7 dichloroquinloine and (p-phenylenediamine 2a, o-phenylenediamine 2b or m-phenylenediamine 2c). The one pot reaction with aldehydes and triphenylphosphite in presence of LiClO4 as a Lewis acid catalyst led to the formation of novel α-aminophosphonate derivatives bearing quinoline moiety in good yields. The synthesi...
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ASTHMA AND HERBAL DRUGS
Asthma is disease of the human respiratory system in which the airways constrict and become narrow, often in response to a “trigger” such as exposure to an allergen, cold air, exercise or emotional stress. Due to rapid industrialization and urbanization, asthma prevalence is predicted to increase more rapidly in the coming years. Despite the availability of a wide range of drugs for the treatm...
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ISOLATION, CHARACTERIZATION OF DEGRADATION PRODUCTS OF SITAGLIPTIN AND DEVELOPMENT OF VALIDATED STABILITY-INDICATING HPLC ASSAY METHOD FOR SITAGLIPTIN API AND TABLETS
The degradation pathway of sitagliptin in bulk and tablet has been investigated during stress study. Major degradation products were isolated in pure form and characterized using mass and NMR spectroscopy. Three previously unreported impurities were found to be, 3-(trifluoromethyl)-6, 7-dihydro[1,2,4]triazolo[4, 3-a]pyrazin-8(5H)-one, (2E)-1-[3-(trifluoromethyl)-5, 6-dihydro[1, 2, 4]triazolo[4, 3-...
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A REVIEW ON ETHNOPHARMACOLOGY, PHYTOCHEMISTRY AND PHARMACOLOGY OF BUDDLEJA ASIATICA
Buddleja asiatica commonly called as butterfly bush is a tender deciduous plant. It is endemic to Asia and found in most parts of India. Traditionally it is used in the treatment of many health disorders such as inflammation, rheumatism, skin disease, malaria etc. In view of pharmacological aspect, Buddleja asiatica is screened for antihepatotoxic, antibacterial, hypotensive, anticancer, antifunga...
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MODIFIED RELEASE FORMULATIONS TO ACHIEVE THE QUALITY TARGET PRODUCT PROFILE (QTPP)
Modified Release (MR) Formulations have a modification in the release mechanism. Modified release dosage forms are developed by altering drug absorption or the site of drug release in order to achieve predetermined clinical objectives. Modified drug release from dosage forms is complemented by the allied processes of drug design, of dosage administration, and of membrane transport and absorption o...
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NANOCAPSULES: A NEW APPROACH IN DRUG DELIVERY
Nanocapsule consists of a thin membrane surrounding a core (Liquid, solid) with their size ranging from 10nm to 1000 nm. Nanocapsules are submicroscopic colloidal drug carrier systems composed of an oily or an aqueous core surrounded by a thin polymer membrane. The membrane may be composed of natural or synthetic polymers. Two technologies can be used to obtain such Nanocapsules: the interfacial p...
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CURRENT SCENARIO OF HERBAL TECHNOLOGY WORLD WIDE: AN OVERVIEW
This article addresses the basic concepts of herbal technology which is used worldwide. 21st century is the century of Biology mechanical and propelled by scientific knowledge and hi-tech expertise. Herbal technology, are going to be the most influential elements that are fundamental for success and welfare for the people of nations.Information on the herbal technologywas collected via electronic ...
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α-GLUCOSIDASE AND α -AMYLASE INHIBITORY ACTIVITIES OF RAPHANUS SATIVUS LINN.
Herbal medicine has been used for many years by different cultures around the world for the treatment of diabetes. There has been an enormous interest in the development of alternative medicines for type 2 diabetes, specifically screening for phytochemicals with the ability to delay or prevent glucose absorption. The goal of the present study is to evaluate the invitro antidiabetic activity of Rap...
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FORMULATION & EVALUATION OF BUFFERED PANTOPRAZOLE SODIUM TABLET
The aim of this study was to prepare buffered tablets of acid labile drug, Pantoprazole sodium for oral administration using buffering agents to protect a drug from gastric fluid. Its mechanism of action was inhibition of H+/K+-adenosine triphosphate, an enzyme present in the gastric parietal cells. The tablets were prepared by wet granulation method. The formulations contain sodium carbonate, sod...
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