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PRELIMINARY PHYTOCHEMICAL ANALYSIS AND THIN LAYER CHROMATOGRAPHY OF THE EXTRACTS OF EXCOECARIA AGALLOCHA L.
Purpose: The focus of the present paper was a preliminary phytochemical and TLC analysis of the various extracts (root, stem, and leaf) of the mangrove plant Excoecaria agallocha L. Methods: Phytochemical analysis was carried out using the standard phytochemical assays. TLC analysis of the petroleum ether and chloroform fraction of the leaves was carried out using the solvent system Toluene: Ethyl...
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IN VITRO ANTIMICROBIAL ACTIVITY OF THE CRUDE EXTRACTS OF COLOCASIA ESCULENTA LEAVES (ARACEAE)
Colocasia esculenta belonging to family araceae popularly knows as “taro”, is very useful medicinal plant described by Charaka as an anti-inflammatory plant. An experiment was carried out to study the antimicrobial activity of chloroform and methanol extract of Colocasia esculenta plant by agar diffusion method. Zone of inhibition produced by chloroform and methanol extract in dose of 20, 10, ...
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A BRIEF REVIEW ON RECENT SYNTHESIS OF 2-AZETIDINONE DERIVATIVES
The chemistry of β-lactams has taken an prestigious place in organic and medicinal chemistry so the review on recent methods in the synthesis of 2-Azetidinone derivatives rendered as a lead molecule for designing potential bioactive agents and it accompanying additional various synthetic information and its orientations would encompass great deal of help to researchers, chemists and pharmacologis...
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SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF NOVEL α-AMINOPHOSPHONATES BEARING A QUINOLINE MOIETY
A novel aminophenylaminoquinoline analogues have been synthesized starting from 4,7 dichloroquinloine and (p-phenylenediamine 2a, o-phenylenediamine 2b or m-phenylenediamine 2c). The one pot reaction with aldehydes and triphenylphosphite in presence of LiClO4 as a Lewis acid catalyst led to the formation of novel α-aminophosphonate derivatives bearing quinoline moiety in good yields. The synthesi...
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NATURAL HABITAT, PHYTOCHEMISTRY AND PHARMACOLOGICAL PROPERTIES OF A MEDICINAL WEED- CLEOME RUTIDOSPERMA DC. (CLEOMACEAE): A COMPREHENSIVE REVIEW
Herbal treatment used in healthcare system from ancient time. Plants had been used by all cultures, ethnic group and society throughout history in the whole world. Plants are the potential source of secondary metabolites which have high medicinal value and huge utility in healthcare development. Herbal medicines are now in huge prospects in the developing and developed nation for basic health trea...
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ANTIEMETICS: A REVIEW
The act of emesis is controlled by the vomiting centre in the medulla, which integrates afferent input from the vestibular system, the chemoreceptor trigger zone (CTZ), the cortex and the gut. Nausea and vomiting induced by several cancer chemotherapy agents is often the most distressing side effect of treatment. The mechanism of action of antiemetic is related to blockage of various type of recep...
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SEAWEED RESEARCH IN INDIA – A NOVEL DOMAIN IN MARINE BIOTECHNOLOGY
Seaweeds are not a common weed, its valued marine plants. In Indian coast around around 800 seaweed species belonging to Chlorophyta, Phaeophyta and Rhodhophyta. Seaweeds constitute one of the commercially important renewable marine living resources. Seaweeds have various commercially valuable products such as pharmaceutical and cosmaceutical compounds, plant growth pro-moters, Nitrogen fixers, bi...
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A NEW VALIDATED RP-HPLC METHOD FOR THE DETERMINATION OF METFORMIN HCL AND EMPAGLIFLOZIN IN ITS BULK AND PHARMACEUTICAL DOSAGE FORMS
A New method was established for simultaneous estimation of Metformin and Empagliflozin by RP-HPLC method. The chromatographic conditions were successfully developed for the separation of Metformin and Empagliflozin by using Symmetry C18 column (4.6×150mm) 5µ, flow rate was 1ml/min, mobile phase ratio was (70:30 v/v) methanol: phosphate buffer (KH2PO4 and K2HPO4) phosphate pH 3 (pH was adjusted ...
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FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF BACLOFEN
The objective of the present study is to develop a pharmaceutically stable sustained release matrix tablets of Baclofen and perform the pre-compression, post compression and in-vitro evaluation studies of developed formulation. In this study sustained release matrix tablets of Baclofen were prepared by wet granulation method using mannitol, HPMC K4M, sodium alginate, HPMC K15 in various concentrat...
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ANTIMICROBIAL ACTIVITY OF BASELLA RUBRA LEAVES
The antimicrobial activities of aqueous, ethanolic and petroleum ether extracts of the leaves of Basella rubra were evaluated in the present study by measuring the inhibition zones using Cup Plate Diffusion method. The inhibition zones were significantly different (P<0.001) in each plant extract. The ethanolic extract showed maximum activity with zone of inhibition (14.3±1.82 mm) against E.col...
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