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SOLUBILITY ENHANCEMENT OF POORLY WATER SOLUBLE CELECOXIB FOR PARENTERAL FORMULATIONS
Celecoxib, a diaryl substituted pyrazole, is practically insoluble in water which precludes its use in parenteral and liquid dosage forms. This study explores the solubility enhancement of celecoxib using hydrotropy and cosolvency solubilization approaches. The equilibrium solubility studies were performed using hydrotropes piperazine, sodium citrate, and urea and cosolvents PEG 200, PEG 400, PEG ...
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A NEW VALIDATED RP-HPLC METHOD FOR THE DETERMINATION OF METFORMIN HCL AND EMPAGLIFLOZIN IN ITS BULK AND PHARMACEUTICAL DOSAGE FORMS
A New method was established for simultaneous estimation of Metformin and Empagliflozin by RP-HPLC method. The chromatographic conditions were successfully developed for the separation of Metformin and Empagliflozin by using Symmetry C18 column (4.6×150mm) 5µ, flow rate was 1ml/min, mobile phase ratio was (70:30 v/v) methanol: phosphate buffer (KH2PO4 and K2HPO4) phosphate pH 3 (pH was adjusted ...
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METHOD DEVELOPMENT AND VALIDATION OF VILDAGLIPTIN AND METFORMIN HCl IN PHARMACEUTICAL DOSAGE FORM BY REVERSE PHASE–HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (RP-HPLC)
Determination of the anti-diabetic drugs vildagliptin and metformin is wildly used to validate drug efficiency in diabetic patients. Here we describe a new and simple chromatographic method to analyze both drugs simultaneously in their commercial pharmaceutical dosage forms. A reverse Phase-high performance liquid chromatography (RP-HPLC) separation method was applied using an Xterra C18 column (2...
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A REVIEW ON THERAPEUTIC POTENTIAL OF NELUMBO NUCIFERA (GAERTN): THE SACRED LOTUS
objectives: Nelumbo nucifera Gaertn (Nelumbonaceae) known by numerous common names including Indian lotus, sacred lotus, bean of India, or simply lotus is one of the most important medicinal plants. In this review there is discussion about therapeutic potential of the different parts of the plant (leaves, seeds, flower, and rhizome) which can be used in traditional system of medicine. This review ...
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A REVIEW ON NATURAL GUMS AND THEIR USE AS PHARMACEUTICAL EXCIPIENTS
Recent past has witnessed the promising roles of natural gums as pharmaceutical ingredients. Gums became important excipients in many pharmaceutical preparations owing to their abundance, biodegradability, non-toxicity and comparatively low cost. They have notable applications in pharmaceutical preparation as binders, disintegrants, suspending agents, emulsifiers. The use of these gums as gelling ...
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SEDATIVE AND HYPNOTIC ACTIVITY OF BULBS OF ALLIUM CEPA LINN.
The onion (Allium cepa L), also known as the bulb onion or common onion, is used as a vegetable and is the most widely cultivated species of the genus Allium. Allium cepa L belongs to the family Lilliaceae. The onion has a wide range of beneficial actions on the body and when eaten (especially raw) on a regular basis will promote the general health of the body. The parameters selected were prelimi...
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BIOSYNTHESIS OF NANOPARTICLES
Biosynthesis of nanoparticles is reviewed in detail in this study. Comparison of different synthesis methods, namely physical, chemical and green methods giving emphasis to biological synthesis is documented here. This study also details limitations of the present techniques and envisages the future scope of nanoparticle biosynthesis. Important applications of nanoparticles are also discussed brie...
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A REVIEW ON: POTENTIAL ANTIDIABETIC HERBAL MEDICINES
Diabetes mellitus (DM) is a metabolic disorder of the endocrine system. This frightful disease is found in all parts of the world and is becoming a serious threat to healthcare providers. Nowadays DM is a most spreading disease in the world. In rapidly growing world a number of treatment options are available for treatment of DM. Long term use of allopathic medicinal agents may cause unwanted side...
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COMPARING GREEN CHEMICAL METHODS AND CHEMICAL METHODS FOR THE SYNTHESIS OF TITANIUM DIOXIDE NANOPARTICLES
Metal nanoparticles are usually synthesized using various chemical methods such as chemical reduction, Solvo-thermal reduction, electrochemical techniques and photochemical reaction in reverse micelles. All these methods are divided into two categories chemical and green chemical. Each having certain advantages and disadvantages. In this study we have tried to give a few examples of these methods ...
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ISOLATION OF β-SITOSTEROL & STIGMASTEROL AS ACTIVE IMMUNOMODULATORY CONSTITUENTS FROM FRUITS OF SOLANUM XANTHOCARPUM (SOLANACEAE)
General phytochemical screening of the aqueous extract of fruits of Solanum xanthocarpum (Solanaceae) revealed the presence of steroids, terpenes, phenolic compounds, saponins, fatty acids, alkaloids. Fractionation of aqueous extract and activity guided isolation resulted in isolation of two white crystalline powder which were subjected to physical, chemical and spectral identification usi...
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