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COUMARINS: AN OVERVIEW OF MEDICINAL CHEMISTRY. POTENTIAL FOR NEW DRUG MOLECULES
Fusion of a pyrone ring with a benzene nucleus gives rise to a class of heterocyclic compounds called Benzopyrones, of which two distinct types are recognized: (1) benzo-α-pyrone commomly called coumarins and (2) benzo-ϒ-pyrone called chromones or flavanoids, latter differing from former only in the position of the carbonyl group in heterocyclic system. Coumarins have attracted considerabl...
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A COMPREHENSIVE REVIEW ON CANCER AND ANTICANCER HERBAL DRUGS
Cancer is a major public health burden in both developed and developing countries. It is an abnormal growth of cells in body that can lead to death and globally the numbers of cancer patients are increasing day by day. There are several medicines available in the market to treat the various types of cancer but no drug is found to be fully effective and safe. Herbal medicines have a vital role in t...
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GREEN CHEMISTRY APPROACH IN SYNTHESIS OF 3,4-DIHYDROPYRIMIDINONE DERIVATIVES UNDER SOLVENT-FREE CONDITIONS
Simplify and improve conditions that have been used traditionally to carry out the conventional Biginelli reactioninvolves three-component one-pot condensation of an aldehyde, β-ketoester and urea or thiourea in ethanol under strong acidic condensation HCl for the synthesis of dihydropyrimidinone(DHPMs) and their sulphur analogue dihydropyrimidinthione derivatives which are act as (antibacterial,...
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PULSATILE DRUG DELIVERY SYSTEM – A REVIEW
Pulsatile drug delivery systems are developed to deliver drug according to circadian behavior of diseases. The product follow a sigmoidal drug release profile characterized by a time period of no release (lag time) followed by a rapid and complete drug release. Thus drug can be delivered at right time, in right amount and at right site of action by use of such approach. The potential benefits of...
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FORMULATION AND EVALUATION OF NOVEL ANTIAGING CREAM CONTAINING RAMBUTAN FRUITS EXTRACT
Skin aging is a complex process induced by constant exposure to ultraviolet (UV) irradiation and damages human skin. Rambutan (Nephelium lappaceum), a delicious tropical fruit that grow in Malaysia and spread widely in most Southeast Asian countries, have strong antioxidants properties due to the presence of ellagic acid, corilagin, geraniin, β-carotene and vitamin C. These compounds scavenge the...
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SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF THIAMINE HYDROCHLORIDE IN PURE FORM, PHARMACEUTICAL AND BIOLOGICAL FLUIDS
Thiamine hydrochloride, also known as Vitamin B1, is a water-soluble vitamin which is important biologically and pharmaceutically. A new simple and sensitive spectrophotometric method has been developed for the determination of Thiamine Hydrochloride (Vitamin B1) in pure form and biological fluids. The method is based on the diazotization reaction of Thiamine Hydrochloride with Procaine HCl which ...
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SYNTHESIS OF NANOSTRUCTURED MAGNESIUM OXIDE BY SOL GEL METHOD AND ITS CHARACTERIZATION
Metals are able to form a large number of oxides. These metal oxides play an important role in many areas of chemistry, physics and material science. An important metal oxide known as magnesium oxide (MgO) having good reactivity is widely used in producing electronics, catalyst, ceramics, oil, paint etc. Magnesium oxide nanoparticle is non-toxic and need a small amount, so it is suitable for the d...
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AN UPDATE ON AYURVEDIC HERB HENNA (LAWSONIA INERMIS L.): A REVIEW
Lawsonia inermis L. is a much branched glabrous shrub or small tree, cultured for its leaves although stem bark, roots, flowers and seeds have also been used in traditional medicine. It has been traditionally reported in use of headache, hemicranias, lumbago, bronchitis, boils, ophthalmia, syphilitis, sores, amenorrhea, scabies, diseases of the spleen, dysuria, bleeding disorder, skin diseases, di...
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COMPARISON OF EFFICACY OF FERROUS CALCIUM CITRATE vs FERROUS ASCORBATE ON Hb STATUS IN ANAEMIC PREGNANT WOMEN
Objectives: To compare the efficacy of ferrous calcium citrate with ferrous ascorbate on Hb levels in anaemic pregnant women. Method: In this observational study, patients receiving ferrous ascorbate with elemental iron 100 mg were allocated to group A and those receiving ferrous calcium citrate with elemental iron 50 mg allocated to group B. After recording the baseline data, their Hb levels, s...
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OXAZOLINES: THEIR SYNTHESIS AND BIOLOGICAL ACTIVITY
Heterocylic chemistry have been known for many years but in recent years heteocyclics received great attention. In heterocyclic chemistry oxazoline is one of the most important moiety. Oxazoline moiety shows a wide range of application such as in agriculture industry, pharmaceutical, food industry, natural product, medicine, polymers and various other industries. Oxazoline moiety constitutes the c...
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