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SIGNIFICANCE OF PHARMACEUTICAL FACTORS ON SELECTION OF BIOBATCH
Biobatch is usually prepared for the purpose of pharmacokinetic evaluation before NDA or IND filing. There are several critical issues that one has to face during the audit process like equivalence between the Biobatch and proposed commercial production batch. During the development and scale-up of the manufacturing process, various standard operating processes have to be documented to provide lin...
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EFFECT OF SEASONAL VARIATION ON SECONDARY METABOLITES OF MEDICINAL PLANTS
Seasonal fluctuations are periodical series, and have impact on availability of active principles in medicinal plants hence, therapeutic efficacy also get influenced. The survey of several scientific studies published in scientific journals of international repute indicates this fact. The studies reported that essential oil component shows a rhythmic increase in oil production throughout the growi...
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A REVIEW ON DELIVERY OF ANTIHYPERTENSIVE DRUGS THROUGH SUBLINGUAL ROUTE
Hypertension is a major risk factor in the development of cardiovascular diseases and has emerged as one of the largest death causing diseases for mankind. There are number of medicines useful for treatment of high blood pressure but the main obstacle for the oral delivery of antihypertensive drugs is low bioavailability due to first pass metabolism. Also, if there is sudden increase in blood pres...
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ACUTE AND 28 DAYS REPEATED ORAL TOXICITY STUDIES OF A SIDDHA DRUG PIRANDAI UPPU ON WISTAR ALBINO RAT
Pirandai uppu (PU) a herbo mineral formulation has been employed as a traditional siddha remedy for diarrhea since long time. Diarrheal diseases remain one of a leading cause of morbidity and mortality in the world, particularly in developing countries. As a mandate, steps were taken to evaluate safety profile of PU in animal model under OECD guidelines. Acute toxicity studies done on female wista...
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FDA WARNING LETTER ANALYSIS: A TOOL FOR GMP COMPLIANCE
In the past few years, the US Food and Drug Administration has issued more warning letters, import alert & seizure to manufacturers of finished product for violation of the current good manufacturing practice regulation. Indian and US Pharmaceutical Manufacturer’s Warning letter from the FDA's Electronic Reading Room were selected as case study and was analyzed for non-compliance of GMP with...
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THE INVASIVE WEED WITH HEALING PROPERTIES: A REVIEW ON CHROMOLAENA ODORATA
Chromolaena odorata or siam weed is regarded as one of the most harmful weeds present on earth. Many efforts are being made for the control of this weed. But, none of them have provided any significant success. It has been utilized in the traditional medicinal systems for its curative properties for centuries. Some of the current studies have revealed its medicinal properties which have lead to an...
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A REVIEW ON ETHANOMEDICINAL USES AND PHYTO-PHARMACOLOGY OF ANTI-INFLAMMATORY HERB VITEX NEGUNDO
Vitex negundo is an important medicinal plant with potent anti-inflammatory activity. The major constituents of this plant are flavonoids, casticin, chryso-splenol and vitexin, Chrysophenol D, nishindine and hydrocotylene. It also contains monoterpenes agnuside, eurostoside, and aucubin. These constituents contribute various pharmacological activities as anti-inflammatory, antioxidant, antinocicep...
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AN UPDATED REVIEW OF PHARMACOLOGICAL STUDIES ON AZADIRACHTA INDICA (NEEM)
Neem has become valuable plant in the world which shows the solutions for hundreds to thousands problems. Neem has become important in the global context today because it offers answers to the major concerns facing mankind. Neem has been extensively used in Ayurveda, Unani and Homoeopathic medicine and has become a centre of attraction of modern medicine. Azadirachta indica (neem) is a rapidly gro...
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POLYPHENOLIC COMPOSITION AND ANTIMICROBIAL POTENTIAL OF METHANOLIC CORIANDER (CORIANDRUM SATIVUM) SEED EXTRACT
The coriander seedextract in 80% methanol is examined for the polyphenol composition and the antimicrobial potential against pathogenic bacteria Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Bacillus pumilus. Gallic acid, caffeic acid, ellagic acid, quercetin and kaempferol are principle polyphenolics identified and quantified in the coriander extract by HPLC. The antimicrob...
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PHYTOCHEMICAL AND PHARMACOLOGICAL PROFILE OF BACOPA MONNIERI – AN ETHNOMEDICINAL PLANT
In recent times, the use of herbal products has increased tremendously in the developing as well as in developed countries. Bacopa monnieri is one of the most important medicinal plant that has been consumed for thousands of year as a memory enhancing, anti-inflammatory, analgesic, antipyretic, sedative and anti-epileptic agent. For many years, a lot of commercial and medicinal researches have bee...
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