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CLINICAL UPDATES ON DRUG – INDUCED CARDIOTOXICITY
Cardiotoxicity associated with the clinically used drugs is a global concern of safety for healthcare professionals. Various animal models have been used to study the drug-induced cardiotoxicity but the exact molecular involvement of toxicity is not much clear. Despite the recurrent occurrence of toxicities, drugs such as doxorubicin, calcium channel blockers, antiarrhythmics and immunomodulators ...
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DEVELOPMENT AND VALIDATION METHOD FOR DECITABINE INJECTION BY RPHPLC
A new, precise, rapid, accurate RP-HPLC method was developed for the estimation of Decitabinein pharmaceutical dosage form. After optimization the good chromatographic separation was achieved by Isocratic mode with a mixture of Ammonium Acetate buffer of pH 4.5: Acetonitrile (985:15) v/v as the mobile phase withDevelosil Rp Aqueous-AR-5 (150 x 4.6 mm, 5 µm), column as stationary phase at flow rat...
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COMMON METHODS TO SYNTHESIZE BENZOTHIAZOLE DERIVATIVES AND THEIR MEDICINAL SIGNIFICANCE: A REVIEW
Recently, heterocyclic compounds analogues and their derivatives have attracted strong interest in medicinal chemistry due to their biological and pharmacological properties. The small and simple benzothiazole nucleus possesses numerous biological properties like - antitumor, antimicrobial, anti-inflammatory, anticonvulsant, and antidiabetic activities. These activities are also possessed by its s...
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STANDARDIZATION OF YAKRIT PLIHANTAK CHURNA: AN AYURVEDIC POLYHERBAL FORMULATION
Most of the traditional systems of medicine are effective but they lack of standardization. So there is need to develop standardization technique. Central Council for Research in Ayurveda has given preliminary guidelines for standardization the conventionally used formulations. Standardization of herbal formulations is essential in order to assess the quality of drugs, based on the concentration o...
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A REVIEW ON DELIVERY OF ANTIHYPERTENSIVE DRUGS THROUGH SUBLINGUAL ROUTE
Hypertension is a major risk factor in the development of cardiovascular diseases and has emerged as one of the largest death causing diseases for mankind. There are number of medicines useful for treatment of high blood pressure but the main obstacle for the oral delivery of antihypertensive drugs is low bioavailability due to first pass metabolism. Also, if there is sudden increase in blood pres...
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ANTIBACTERIAL ACTIVITY OF SOME SELECTED INDIAN MEDICINAL PLANTS
There is a continuous and urgent need to discover new antimicrobial compounds with diverse chemical structures and novel mechanisms of action because there has been an alarming increase in the incidence of new and re-emerging infectious diseases. In recent years, drug resistance to human pathogenic bacteria has been commonly reported from all over the world. In the present scenario of emergence of...
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CHARACTERISATION OF NARIKELA LAVANA
Background: Narikela lavana is a classical formulation which has been described in the samhitas such as Chakradatta, Vangsena, Bhavaprakash, and Rasa tarangini. The main indication of Narikela lavana is Parinaam shoola which can be broadly correlated with Peptic ulcer as per the modern parameters. As the name suggests, Narikela lavana contains only two ingredients- Narikela (coconut) and saindhava...
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ADVERSE DRUG REACTIONS ASSOCIATED WITH ANTI-HYPERTENSIVE DRUGS AND ITS MANAGEMENT
Adverse Drug Reactions associated with drugs are common and impose a serious health related problem, which can limit the treatment options, compliance and even leads to discontinuation of therapy. Hypertension is a chronic disease condition which is considered to be one of the major cardiovascular risk factor. For the treatment of hypertension a wide range of anti-hypertensive agents are available...
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AN OVERVIEW ON ARACHIS HYPOGAEA PLANT
The peanut or groundnut (Arachis hypogaea) is a species in the legume family (Fabaceae). There are different varieties like Virgina group, Spanish group, Runner group, Valencia group, Tennessee red and Tennessee white. Peanut consists of 30 essential nutrients and phytonutrients. Peanuts are a good source of vitamins & metals. Peanut hulls consist of crude fiber, cellulose, water, crude protei...
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EMULGEL: AN EMERGENT TOOL IN TOPICAL DRUG DELIVERY
In comparison among the other groups of semisolid preparations, the use of gels has been emerged both in cosmetics and in pharmaceutical preparations because of its unique array of features. Despite of providing several benefits the category gel faces limitations in delivering hydrophobic drug molecules via skin. So in order to cover up this lacking a recent emulsion based approach is bein...
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