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COMMON METHODS TO SYNTHESIZE BENZOTHIAZOLE DERIVATIVES AND THEIR MEDICINAL SIGNIFICANCE: A REVIEW
Recently, heterocyclic compounds analogues and their derivatives have attracted strong interest in medicinal chemistry due to their biological and pharmacological properties. The small and simple benzothiazole nucleus possesses numerous biological properties like - antitumor, antimicrobial, anti-inflammatory, anticonvulsant, and antidiabetic activities. These activities are also possessed by its s...
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FEMALE INFERTILITY: AN OVERVIEW
Female infertility is the major disorder which has altered the man kind foe lack of conception and reproducibility, stressful world, excess radiation, lack of biological food, genetically disorder ,changing life style, increased electronic discharge have resulted the female infertility. Infertility/ childlessness cause great personal suffering & distress. Most of this agony & misery is hid...
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NATURAL COLORANTS FROM PLANTS FOR WELLNESS INDUSTRY
Colorants are widely used in food, cosmetics, pharmaceutical, nutraceutical and textile industry to improve customer perception and acceptability. The hazardous effects and legislation of synthetic dyes minimize its applications thus the search for natural pigments is in trend. Plant natural pigments are widely used as alternative not only because of their high availability as colouring agent, but...
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NEEDLE FREE INJECTION SYSTEMS
Needle-free injection systems are novel ways to introduce various medicines into patients without piercing the skin with a conventional needle. Needle-free technology offers the very obvious benefit of reducing patient concern about the use of needle. Needle free injection gives very effective injections for a wide range of drugs and bioequivalent to syringe and needle, results in less pain, a...
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A COMPARATIVE STUDY TO EVALUATE ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY OF COMMONLY USED PROTEOLYTIC ENZYMES AND THEIR COMBINATION WITH DICLOFENAC IN RATS
Introduction: Proteolytic enzymes like serratiopeptidase, trypsin and chymotrypsin are used for prolonged period for edema resolution in post-operative patients, arthritis, tooth extraction etc. either alone or with other anti-inflammatory agent. Various trials have supported and refused the role of enzymes as anti-inflammatory agents. No study was found for analgesic property of proteolytic enzym...
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A COMPARATIVE STUDY OF MYO INOSITOL VERSUS METFORMIN ON BIOCHEMICAL PROFILE IN POLYCYSTIC OVARIAN SYNDROME IN WOMEN
Objective: PCOS is a common endocrine disorder in women of reproductive age associated with insulin resistance. Metformin and Myo-inositol being insulin sensitizers improve biochemical parameters. This study was done to compare the effects of these drugs on biochemical profile in PCOS. Material and Methods: A prospective, open labeled, randomized, comparative, clinical study was conducted on 60 pa...
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HPLC-ELSD DETERMINATION OF SODIUM LAURYL SULPHATE AND POLYSORBATE IN NEBIVOLOL DRUG PRODUCT AND DIFFERENT FORMULATION PRODUCTS
The contents of Sodium lauryl sulphate (SLS) and Polysorbate (Tween 80) were studied in different formulations of Nebivolol film coated tablets. The contents were extracted using the diluent Methanol: Water in the ratio 60:40 v/v and analyzed in HPLC coupled with Evaporative light scattering detector (ELSD). SLS and Tween 80 are solubilizing agents and the amount of these contents are critical in ...
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CLINICAL UPDATES ON DRUG – INDUCED CARDIOTOXICITY
Cardiotoxicity associated with the clinically used drugs is a global concern of safety for healthcare professionals. Various animal models have been used to study the drug-induced cardiotoxicity but the exact molecular involvement of toxicity is not much clear. Despite the recurrent occurrence of toxicities, drugs such as doxorubicin, calcium channel blockers, antiarrhythmics and immunomodulators ...
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ANTI-OXIDANT AND ANTI-INFLAMMATORY ACTIVITY OF CUCUMIS SATIVAS (CUCUMBER) FLOWERS
Cucumis sativus (Cucumbers) have not received as much press as other vegetables in terms of health benefits, but this widely cultivated food provides us with a unique combination of nutrients. At the top of the phytonutrient list for cucumbers are its cucurbitacins, lignans, and flavonoids. These three types of phytonutrients found in cucumbers provide us with valuable antioxidant, anti-inflammato...
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ADVERSE DRUG REACTIONS ASSOCIATED WITH ANTI-HYPERTENSIVE DRUGS AND ITS MANAGEMENT
Adverse Drug Reactions associated with drugs are common and impose a serious health related problem, which can limit the treatment options, compliance and even leads to discontinuation of therapy. Hypertension is a chronic disease condition which is considered to be one of the major cardiovascular risk factor. For the treatment of hypertension a wide range of anti-hypertensive agents are available...
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