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BUCCAL PATCHES: A REVIEW
Buccal route is an attractive route of administration for systemic drug delivery and it leads direct access to the systemic circulation through the internal jugular vein bypasses drugs from the hepatic first pass metabolism provides high bioavailability. Buccalbioadhesive films, releasing topical drugs in the oral cavity at a slow and predetermined rate, provide distinct advantages over traditiona...
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MORPHOLOGY, PHYTOCHEMISTRY AND PHARMACOLOGY OF SYZYGIUM CUMINI (LINN.) – AN OVERVIEW
Syzygium cumini (L.) is a widely used medicinal plant for the treatment of various ailments. The plant contains anthocyanins, glucoside, ellagic acid, isoquercetin, kaempferol, and myricetin as its chief active constituents. These active cons isoquercetin, kaempferol tituents impart multiple pharmacological activities to the plant which includes antidiabetic, anticancer, antioxidant, antibacterial...
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HPLC ANALYSIS OF CEPHALOSPORINS AND STUDY OF DIFFERENT ANALYTICAL PARAMETERS
Cephalosporins are the most important type of antibiotics used vary widely. Analysis of these antibiotics is challenge because of their sensitivity and instability to different conditions. The present review is extended to find out different HPLC methods used for analysis for cephalosporins in formulations and biological fluids. The chromatographic conditions used for the analysis as well as analy...
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A BRIEF OVERVIEW ON MOLECULAR DYNAMICS SIMULATION OF BIOMOLECULAR SYSTEM: PROCEDURE, ALGORITHMS AND APPLICATIONS
Molecular Dynamics (MD) Simulation provides the details explanation of the atomic and molecular interactions that directed by macroscopic and microscopic behaviors of the various systems. This review provides a brief do-how about the theory, procedure, algorithm, and uses of molecular dynamic simulations in different bimolecular systems. An in-depth analysis of different prospects of MD simulation...
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DEVELOPMENT AND VALIDATION METHOD FOR DECITABINE INJECTION BY RPHPLC
A new, precise, rapid, accurate RP-HPLC method was developed for the estimation of Decitabinein pharmaceutical dosage form. After optimization the good chromatographic separation was achieved by Isocratic mode with a mixture of Ammonium Acetate buffer of pH 4.5: Acetonitrile (985:15) v/v as the mobile phase withDevelosil Rp Aqueous-AR-5 (150 x 4.6 mm, 5 µm), column as stationary phase at flow rat...
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FORMULATION AND EVALUATION OF LEVOFLOXACIN OINTMENT
We intended desired ointment developed for bacterial infection. So Levofloxacin is a fluoroquinolones of antibacterial drug effective in the treatment of bacterial conjunctivitis, sinus, kidney, bladder or prostate Here the main objective of the present work is besides delivering drugs to the body, A drug delivery system to improve patient compliance and dispersible are no exception. So we hav...
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GOLD NANO-CONJUGATES: A LEAP IN CANCER TREATMENT
The use of nanoparticles as drug delivery and targeting agents has led to immense progress in the field of biomedicine and diagnostics. Likewise gold nanoparticles can be conjugated with various molecules, for instance, to plasmid DNA for gene therapy, to various drugs for antibacterial and anticancer properties, to several antibiotics and peptides for immunological and diagnostic purposes. The re...
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VARIOUS ANIMAL MODELS FOR PRECLINICAL TESTING OF ANTI-INFLAMMATORY AGENTS
Inflammation is the local defensive response of living tissues to injury or due to any other chemical agents. Inflammation consists of two basic processes early inflammatory response later followed by healing. There are two types of inflammation, acute and chronic. The different animal models (i.e. vascular permeability, UV-erythema in guinea pigs, Croton-oil ear edema in rats and mice, Paw edema ...
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PHYTOCHEMICAL PROFILING, ANTIBACTERIAL SCREENING AND ANTIOXIDANT PROPERTIES OF THE SACRED TREE (SHOREA ROBUSTA GAERTN.) OF JHARKHAND
Shorea robusta Gaertn., commonly called as Sal tree, is revered as a sacred tree by most of the tribals of Jharkhand, India. They do not worship it rather believe it to the abode of tribal goddess. The plant parts are used as a remedy against various ailments in combination with other ingredients. Preliminary phytochemical screening of the whole plant exhibited the presence of high concentration o...
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A REVIEW ON ENDEMIC INDIAN RESURRECTING HERB SELAGINELLA BRYOPTERIS (L.) BAK. ‘SANJEEVANI’
Selaginella bryopteris (L.) Bak. usually known as “Sanjeevani’, is a lithophyte with remarkable resurrection capabilities and medicinal properties. It is traditionally used for curing wounds and irregular menstruation, uterine disorders and other internal injuries. It contains a variety of secondary metabolites such as alkaloids, phenol and terpenoids etc due to which it can act as antioxidant...
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