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REVIEW ON THE CONCEPT OF IMMUNOMODULATION IN AYURVEDA WITH SPECIAL EMPHASIS ON PRAKARA YOGA
An immunomodulator can be defined as a substance, which can influence any constituent or function of the immune system in a specific or nonspecific manner including both innate or adaptive arms of the immune response. The Ayurvedic system of medicine details the concept of immunomodulation by the term Rasayana. The use of herbs for improving the overall resistance of body against common infections...
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2785
TOPICAL LIPOSOMAL GEL: A REVIEW
Liposomes have been established as a promising novel drug delivery vehicle in several different basic sciences. Liposomes are microscopic spheres with an aqueous core surrounded by one or more outer shells consisting of lipids arranged in a bilayer configuration. Liposomes are acceptable superior carriers having ability to encapsulate hydrophilic and lipophilic drugs and protect them from degradat...
12841
2070
A REVIEW ON PHYTOCHEMICAL AND PHARMACOLOGICAL PROPERTIES OF PHYLLANTHUS AMARUS SCHUM. AND THONN.
Phyllanthus amarus Schum and Thonn herb is in traditional medicine for more than 3000 years. It belongs to a family of Euphorbiaceae and commonly known by the name of carry me seed, stone breaker, gala of wind, etc. It is a branching annual herb of 30 - 60 cm height widely spread throughout tropics and sub-tropics as a weed. Phyllanthus amarus is gaining momentum for its hepatoprotective, anti-car...
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3370
EFFECT OF LIGHT AND HEAT ON STABILITY OF CRUDE CAROTENOID EXTRACT FROM NATURAL SOURCES
Carotenoids are accessory coloring pigments found occurring naturally in the plants and some photosynthetic organisms. Recently there has been an increased focus on the health benefits and food applications of these natural pigments. The stability and bioavailability of carotenoids vary significantly across a range of processing paradigms. The present study was planned to investigate stability o...
12779
1910
LIFE CYCLE APPROACH TO CLEANING VALIDATION
The regulatory expectations are changing day by day on the cleaning validation in Pharmaceutical industries, considering the patient safety and drug efficacy. Manufacturing of an Intermediate and Active Ingredient Pharmaceuticals involves many chemical syntheses and same equipment is being using for manufacturing of different product in multi-production facility. Equipment cleaning plays a key rol...
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3278
IMPROVEMENT OF SOLUBILITY OF BADLY WATER SOLUBLE DRUG (IBUPROFEN) BY USING SURFACTANTS AND CARRIERS
Although there was a great interest in solid dispersion systems during the past four decades to increase dissolution rate and bioavailability of badly water-soluble drugs, their profitable use has been very limited, primarily because of manufacturing difficulties and stability problems. In this study solid solutions of drugs were generally produced by fusion method. The drug along with the excipie...
12650
1988
PREPARATION AND CHARACTERISATION OF β-CYCLODEXTRIN NEBIVOLOL INCLUSION COMPLEX
Nebivolol HCl (NEB) is antihypertensive drug having β-adrenergic blocking properties. Although NEB is rapidly absorbed after oral administration, it has low bioavailability (12%), due to its low water solubility. The purpose of present work was to enhance the solubility and dissolution rate of NEB by inclusion complexation technology. Complexation is the association between two or more molecules ...
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REGULATORY CHALLENGES IN GLOBAL PHARMACEUTICAL MARKET
The global pharmaceutical industry “looks like the epitome of a modern, mature industry that has found a comfortable way to make profits by the billion: it’s global, hi-tech, and has the ultimate customer, the health care budget of the world’s richest countries. A number of factors contributed to the globalization of the pharmaceutical industry. Chief among these are the convergence of medic...
12611
1821
ISOLATION AND CHARACTERIZATION OF BIOACTIVE ACTINOMYCETES FROM SOIL IN AND AROUND NAGPUR
ABSTRACT: Fifteen soil samples were collected from different locations near Nagpur i.e. from Nagpur, Bhandara and Chandrapur. Air drying and pre-treatment of soil samples with CaCo3 (1%) were found to be most effective for isolation of actinomycetes. Five different selective media were used for the isolation of actinomycetes and the best growth was observed in yeast malt extract agar medium with 1...
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4290
ANTIBACTERIAL ACTIVITY OF SOME SELECTED INDIAN MEDICINAL PLANTS
There is a continuous and urgent need to discover new antimicrobial compounds with diverse chemical structures and novel mechanisms of action because there has been an alarming increase in the incidence of new and re-emerging infectious diseases. In recent years, drug resistance to human pathogenic bacteria has been commonly reported from all over the world. In the present scenario of emergence of...
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1722