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THREE GENERATIONS: PIMARY, SECONDARY AND TERTIARY GENERATIONS OF TRANSDERMAL DRUG DELIVERY SYSTEMS: A REVIEW
From this article, we get the knowledge about the transdermal patch, transdermal drug delivery system and anatomy of the skin. Now-a-days transdermal drug delivery, system is widely used in much disease. So, this article gives the knowledge about pre transdermal system, post transdermal drug delivery system and future of transdermal drug delivery systems and examines the benefits and limitations o...
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FORMULATION AND EVALUATION OF LIPOSOMES OF FENOFIBRATE PREPARED BY THIN FILM HYDRATION TECHNIQUE
The objectives of the present study were to use design of experiments (DOE) for formulation and optimization liposomal formulations and study the impact of process variables on quality attributes of the complex liposomal formulation system. Several factors may have contributed to the slow pace of commercialization of liposome drug products during the last decade: 1) the difficulties associated wit...
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THUJA OCCIDENTALIS L. (CUPRESSACEAE): REVIEW OF BOTANICAL, PHYTO-CHEMICAL, PHARMACOLOGICAL AND TOXICOLOGICAL ASPECTS
Thuja occidentalis called the tree of life is an endemic plant in eastern North America and cultivated in northern Europe and in Brazil as ornamental tree. According to the popular use of this plant has been used in herbal and homeopathic preparations for acute and chronic infections of the upper respiratory tract, warts, as adjunctive antibiotic, immunostimulant. However, these and other data are...
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RESEALED ERYTHROCYTES AS A NOVEL CARRIER FOR DRUG DELIVERY: A REVIEW
Drug delivery systems including chemical, physical and biological agents that can enhance the bioavailability, improve pharmacokinetics and reduce toxicities of the drugs. Carrier erythrocytes are one of the most promising biological drug delivery systems investigated in recent decades. Resealed Erythrocytes are biocompatible, biodegradable, possess long circulation half-life and can be loaded wit...
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PHYTOCHEMICAL ANALYSIS OF TINOSPORA CORDIFOLIA (WILLD.) MIERS EX HOOK. F. & THOMS STEM OF VARIED THICKNESS
Tinospora cordifolia (Giloe/Guduchi) belonging to the family menispermaceae, is a large extensively spreading glabrous, perennial deciduous twiner with succulent stems and papery bark. It is widely used in Ayurvedic system of medicine “Rasayanas” to the immune system and the body resistance against infections. In modern medicine, T. cordifolia is used for the treatment of general weakness, fev...
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CRITICAL ROLES PLAY OF MAGNESIUM STEARATE IN FORMULATION DEVELOPMENT OF A HIGHLY SOLUBLE DRUG METFORMIN HYDROCHLORIDE
This article is giving emphasis on the decisive role of particle size of highly hydrophobic lubricant i.e. Magnesium Stearate, its concentration and lubrication time to establish the desired quality attributes of formulation containing highly soluble model drug Metformin Hydrochloride. Magnesium Stearate from two sources with different Particle size distribution (PSD) range was selected. It was ob...
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A REVIEW ON COLON TARGETED DRUG DELIVERY SYSTEM
The oral route is considered to be the most preferred route for administration of drugs for systemic effect, but the oral route is not suitable to the administration of drug for lower gastrointestinal (GI) diseases, this happened due to their release at upper GI tract (stomach, small intestine), which further minimizes the accessibility of drugs at the lower GI tract. To overcome this difficulty, ...
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PHARMACOGNOSTIC STUDIES ON LEAF OF JATROPHA GOSSYPIFOLIA L.
Since, the free radicals induced oxidative stress is posing threat present researchers are focusing on natural sources that could serve as antioxidants to combat the oxidative damage mediated diseases such as diabetes, atherosclerosis and cancer. In this context, present study was carried out to investigate the botanical characters, chemical composition and in vitro antioxidant potential of Jatrop...
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THERAPEUTIC POTENTIAL OF WITHANIA SOMNIFERA: A REPORT ON PHYTO-PHARMACOLOGICAL PROPERTIES
Withania somnifera belongs to the Solanaceaefamily, commonly known as Ashwagandha, Indian ginseng or Winter cherry. It is an important commercial medicinal crop, considered as similar to Panax ginseng in Chinese medicine. Different parts of this plant are used in traditional medicine for the treatment of various ailments. It provides defense against diseases, adverse environmental factors and help...
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PHYTOCHEMICAL AND PHARMACOLOGICAL POTENTIAL OF NERIUM OLEANDER: A REVIEW
Nerium oleander L. is an important medicinal material in Chinese folk medicine. In early times it is assumed that all parts of the oleander plant are poisonous to humans, animals and certain insects but now a day's numbers of pharmacological activities are determined by different scientists. Its main active constituents are polysaccharides, cardenolides, glycosides, and triterpenoids. The importan...
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