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ASSESSMENT OF KNOWLEDGE, ATTITUDE AND PRACTICES OF ADVERSE DRUG REACTION REPORTING AMONG NURSING STAFF OF TERTIARY CARE TEACHING HOSPITAL IN WESTERN RURAL INDIA
Introduction: Underreporting of adverse drug reactions (ADRs) in Pharmacovigilance programme of India (PvPI) may be due to lack of adequate knowledge, attitude and practice among healthcare professionals towards ADR reporting. Aim & Objective: Present study was planned to assess the knowledge, attitude and practices of ADR reporting amongst nursing staff of tertiary teaching hospital in Wester...
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PHYTOCHEMICAL & PHYSIOCHEMICAL SCREENING OF THE HERBAL DRUG ALOEVERA AND CLITORIA TERNATEA LEAVES EXTRACT
Egyptians referred to aloe vera, a botanical remedy, as "the plant of immortality." It helps with diabetes, hypertension, wound healing, and other medical conditions. Aloe vera gel extract and Clitoria ternatea watery, methanolic, and ethanolic extracts of plants was studied. A small sample of Aloe vera and Clitoria ternatea's ethanolic, methanolic, and watery extracts were put through a phytochem...
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DEVELOPMENT AND VALIDATION OF SECOND-ORDER DERIVATIVE UV SPECTROPHOTOMETRIC ESTIMATION OF FAVIPIRAVIR ANTIVIRAL DRUG
Objectives: The present study aims to develop a simple, precise, accurate, and reproducible spectrophotometric Second order derivative method for estimating Favipiravir in bulk and pharmaceutical dosage form. Method: Acetonitrile was used as an organic solvent. The maximum absorption of the drug was found to be at 323nm. The developed method was validated and applied for the estimation of Favipira...
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SOLID DISPERSION: STRATEGIES TO ENHANCE SOLUBILITY AND DISSOLUTION RATE OF POORLY WATER-SOLUBLE DRUG
The solubility problem of drugs is always one of the most challenging aspects in formulation and development of dosage forms. In fact, most of new chemical entities are poorly water soluble and not well-absorbed after oral administration resulting in low bioavailability. The current challenges of the pharmaceutical industries are related to techniques that improve the water...
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THERAPEUTIC EFFECT OF LEAVES OF AYAPANA TRIPLINERVIS IN INDOMETHACIN INDUCED MILD, MODERATE AND SEVERE GRADE GASTRIC ULCER
Peptic ulcer disease (PUD) is increasing gradually in India as well as worldwide. Excess use of non-steroidal anti-inflammatory agents (NSAID) and lifestyle factors cause gastric mucosal damage. This study was designed to search out the gastro-protective efficacy of hydromethanolic extract of Ayapana triplinervis on different graded ulcers. Mild to severe grade of gastric ulcer has been developed ...
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PHYTOCONSTITUENT ANALYSIS AND IN-VITRO ANTI-INFLAMMATORY ACTIVITIES OF PLANTS SOURCES
Bioactive compounds are secondary plant metabolites and are found in small amounts in plants, fruit, vegetables, and edible oils; they have health benefits and provide us an alternative search for drugs or medicines and followed by the minimum side effects. There are various bioactive assays for measuring the functional activities of bioactive compounds, such as phytochemical assays and anti-infla...
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EXHAUSTIVE REVIEW ON THERAPEUTICAL ROLE OF SOME PHYTOCONSTITUENTS AND THEIR CHEMICAL ALTERATION
Introduction: Therapeutic agent must be compatible with its target. Their multiple interaction produces diversified therapeutic action. Chemical exploration of phytoconstituents unravels bio-interaction and strategic engineering of molecules generates wonderful leads in therapeutics. Method: The source of information has been accessed through multiple research and review article of peered journals...
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PHYTOSOMAL NANOCARRIER LOADED WITH EMBELIA RIBES DEVELOPMENT FOR CANCER THERAPY
Background: In this study, Embelia ribes fruit extract phospholipid complex (ERE-PC) was developed with an attempt to enhance the therapeutic effect by improving its dissolution profile and oral bioavailability. E. ribes, an ancient herb possesses anticancer, anti-fertility, antimicrobial and anti-diabetic activities. However, poor aqueous solubility of phytoconstituents of E. ribes, lowers the th...
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A STUDY OF VANCOMYCIN INTERMEDIATE RESISTANCE AND HETERORESISTANCE IN CLINICAL ISOLATES OF METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS AT A TERTIARY CARE HOSPITAL
Background: Methicillin resistant Staphylococcus aureus (MRSA) is known to cause various infections ranging from minor skin and soft tissue infections to devastating septicaemia and endocarditis. The only drug that is currently most effective against MRSA infections is a glycopeptide, vancomycin. Due to continued exposure and injudicious use of this novel drug, cases of reduced susceptibility to v...
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DEVELOPMENT AND VALIDATION OF A METHOD FOR QUANTIFICATION OF SIPONIMOD IN SPIKED RAT PLASMA
The creation of reliable bioanalytical LC-MS (liquid chromatography-mass spectroscopy) methods is crucial for the discovery, development, and eventual marketing approval of new drugs. A brand-new medication called siponimod was developed to treat Multiple Sclerosis (MS). This medication is a sphingosine-1-phosphate (S1P) receptor modulator and is hypothesised to contribute to the reduction of MS-r...
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