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CURRENT LANDSCAPE FROM CLINICAL TRIALS AND FUTURE OF COMBINED CHECKPOINTS BLOCKADE IMMUNOTHERAPY IN CANCERS
Immunotherapy is among cancer immunology's fastest and most furious treatment strategies. The therapeutic perspective of checkpoint inhibitors is represented through the Food and Drug Administration (FDA) approvals for their implementation in various malignancies. Efforts to improve results with immunotherapeutic agents have led to the design of advanced treatment strategies. Current pre-clinical ...
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DESIGN, SYNTHESIS, DNA-BINDING AND DOCKING STUDY OF 2,4-DIMETHOXY ACRIDONES AS CYTOTOXIC AGENTS
A series of novel N10 -substituted 2,4-Dimethoxy acridones were synthesized as potent cytotoxic agents. DNA-binding studies of the synthesized compounds were carried out by the HPLC method using Calf thymus DNA (CT - DNA) based on their affinity or intercalation with CT-DNA, measured by binding percentage. The compound 12 bearing planar dimethoxy tricyclic ring linked with butyl pyrazole side chai...
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REVIEW ON PATHOPHYSIOLOGY OF MIGRAINE: TYPES AND VARIOUS ANTIOXIDANTS
The review briefs the information mainly about migraine disease. It tells about genes that are responsible for migraine. Alternating Hemiplegia in Childhood, Cortical spreading depression, Monogenic Migraine, Hemicrania Ophthalmoplegia, Hemicrania Alia Definite, Hemicrania, Complicated Migraine, Status Migrinous these are types of migraine, sign and symptoms also included. The history gives all th...
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KNOWLEDGE, ATTITUDE, AND PRACTICE OF TYPE 2 DIABETES MELLITUS PATIENTS IN A TERTIARY CARE TEACHING HOSPITAL IN SOUTHERN ASSAM, INDIA
Background: Type 2 diabetes mellitus is increasing very rapidly in India, yet studies regarding knowledge, attitude and practices in diabetes in various Indian communities, especially in the Northeastern region, are limited. It is essential to understand the current gaps in knowledge and problems with the attitude and perceptions of the general population regarding diabetes to effectively plan pub...
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MILLET FOOD WASTE AS MEDICINE FOR MANAGEMENT OF LIFESTYLE DISORDERS
Plant foods are wasted especially in millets as they are not required in that particular product processing. From the cultivation of millet to its processing and consumption of the final product, a significant amount of waste is generated. Wasted foods are not spoilt foods and still have the potential to be used for the second time as food. But unfortunately, the fate of waste is always landfill...
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AN EFFICIENT METHOD FOR ANTHER AND OVARY CULTURE IN ABELMOSCHUS ESCULENTUS (L.) MOENCH. IN-VITRO
Okra (Abelmoschus esculentus (L.) Moench.) is an important nutrient-rich vegetable crop also known as “lady’s finger”, widely grown in the tropics and sub-tropics mainly for its edible pods and is an alloploid. The haploid technique has been used in plant breeding for the improvements of plants and to develop new varieties in a relatively short time. Hence, we have optimized several factor...
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VALIDATED SPECTROSCOPIC AND CHROMATOGRAPHIC TECHNIQUES FOR QUALITY CONTROL ANALYSIS OF APIGENIN IN HERBAL MEDICINES
The herbal medicines have been largely used since form several thousands of years in all developing and developed countries in the primary health care of community and society. Flavonoids are the class of polyphenolic secondary metabolites, which are mainly found in plants. Apigenin is a flavonoid which shows several pharmacological activities and used effectively for the management and treatment ...
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QUALITY ANALYSIS OF MARKET SAMPLES OF ŌRILA COLLECTED FROM DIFFERENT MARKETS OF KERALA USING PHARMACOGNOSTIC TOOLS
Ōrila is a well-known drug used in many Ayurvedic recipes in kerala. In most texts Ōrilais seen paired with Mūvilaand together they fare as components of the Daśamula. From very old Kerala commentaries of ancient Ayurvedic texts, Ōrila and Mūvila are seen as Malayalam translations of Pṛśniparṇī and Śālaparṇī respectively. In Kerala Pṛśniparṇīis often identified as Ōrila and...
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CONCISE OVERVIEW ON OVARIAN CANCER AND ITS TREATMENT PARP INHIBITOR, TARGETED DRUG THERAPY, IMMUNOTHERAPY AND MORE
The primary cause of death for women with gynaecological cancer diagnoses is ovarian cancer. It is also, generally speaking, the sixth most common cause of death for women. The majority of cases had advanced diagnoses, which worsens the disease's prognosis. The limited predictive value of the current screening tests adds even more suffering to the situation. The most important early detection tech...
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EFFECT OF EDUCATIONAL INTERVENTION ON MATERNAL KNOWLEDGE IN USE OF ANTIBIOTICS IN ACUTE RESPIRATORY INFECTIONS AMONG UNDER FIVE CHILDRENIN URBAN FIELD PRACTICE AREA OF MEDICAL COLLEGE BANGALORE
Background: Acute respiratory infections are the most important cause of mortality and morbidity among under-five children in developed and developing countries in the world. There is lack of awareness/ knowledge among parents regarding antibiotic use in children for minor respiratory ailments. Hence, the present study was undertaken. Methods and Methodology: After taking institutional ethical cle...
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