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A NOVEL THERAPEUTIC EFFECT OF THE WOUND HEALING ACTIVITY OF BOSWELLIA SERRATA EXTRACT (BOSWEGEX®) BY USING THE HUMAN DERMAL FIBROBLAST (HDF) CELL LINE: AN IN-VITRO STUDY
The Indian medicinal plant Boswellia serrata, sometimes known as frankincense in the West, has been used in traditional medicine to heal burns and wounds. The objective of this study was to investigate the capability of B. serrata (Boswegex®) to enhance wound healing by carrying out an in-vitro scratch experiment on human dermal fibroblast cells (HDF). Povidone-Iodine 5% cream was used as a posit...
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COMPARISON OF ANALGESIC EFFECTS OF 2-BENZOXAZOLINONE AND STANDARDIZED SUPERCRITICAL FLUID EXTRACT OF ACANTHUS ILICIFOLIUS ON ANIMAL MODELS OF PAIN AND MUSCULAR HYPERALGESIA
The objective of this study was to evaluate the analgesic properties of supercritical fluid extracts of Acanthus ilicifolius leaves (SCFE-AI) and Benzoxazolinone (BOA) using the acetic acid-induced writhing method, formalin-induced paw lick assay, and carrageenan-induced muscle hyperalgesia. Results demonstrated that SCFE-AI and BOA exhibited potent dose-dependent analgesic activity in all tested ...
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DISSOLUTION ENHANCEMENT OF ROSUVASTATIN CALCIUM BY USING VARIOUS GENERATIONS OF HYDROPHILIC POLYMERS: A COMPARATIVE STUDY
Oral administration is the preferred route of drug administration owing to its convenience, patient compliance, and cost-effectiveness. The study aspired to augment the solubility and dissolution rate of Rosuvastatin calcium (RST) by using the solid dispersion (SD) technique with various generations of hydrophilic polymers. Hot melt and solvent evaporation methods were employed to prepare SD using...
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EVALUATION OF THE EFFECTIVENESS OF THE EFFECT OF ACETYLCYSTEINE ON INTRARENAL HEMODYNAMICS IN PATIENTS WITH CORONAVIRUS ASSOCIATED NEPHROPATHY
This article discusses the assessment of kidney function in patients with coronavirus-associated nephropathy through Doppler ultrasound of renal vessels. The study focuses on research groups comprising individuals affected by this nephropathy. Dopplerography studies aim to evaluate the effectiveness of N-acetylcysteine in treating coronavirus-associated nephropathy. Doppler ultrasound helps assess...
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VALIDATION OF STABILITY INDICATING RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF AXITINIB AND AVELUMAB BY USING ANALYTICAL QUALITY BY DESIGN (AQbD) METHOD
The quantitative measurement of Axitinib and Avelumab has been created using a simple, quick, precise, sensitive, and reproducible reverse-phasehigh-performance liquid chromatography (RP-HPLC) method. It is more difficult to analyse varying amounts of pharmaceutical active medicinal ingredients in dose forms without any interferences. Therefore, the objective of the current work is to estimate Axi...
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COMPARISON OF EFFICACY OF TWO TYPES OF MUSIC PLAYED INTRA-OPERATIVELY AS AN ADJUNCT TO SPINAL ANESTHESIA FOR BETTER PERI-OPERATIVE EXPERIENCE OF THE PATIENT: A RANDOMISED CONTROL STUDY
Aim: To compare the effects of two types of music (meditation and devotional) played intra-operatively and control (no music) as an adjunct to spinal anaesthesia for better and holistic approach to perioperative care of the patient. Methodology: A prospective, randomised control study was conducted at a tertiary care hospital with 60 patients. The patients were randomly allocated into three groups...
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NOVEL PYRIMIDINE DERIVATIVES AS POTENTIAL ANTIMICROBIAL AGENTS: SYNTHESIS AND BIOLOGICAL EVALUATION
The pyrimidine scaffold found in many bioactive drugs; some commercially available drugs containing at least one pyrimidine ring in their structure. The literature survey reveals that replacement of 1H-pyrazole of pyrazolo [3,4-d] pyrimidine ring system by other bioactive moieties drastically alters its pharmacological properties. Prompted by the varied biological activities of pyrazolopyrimidine ...
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IN-SILICO PHARMACOKINETIC PROPERTIES PREDICTION OF COUMARINS PRESENT IN AEGLE MARMELOS L.
Aegle marmelos L. (Bael Fruit) is rich in bioactive compounds such as coumarins, alkaloids, terpenoids, tannins, flavonoids, and essential oils. This article focused on the pharmacokinetic profiling of coumarins present using an in silico ADME tool called SwissADME which contributes to a better understanding of enhanced drug monitoring and individualization of drug therapy. Log S (ESOL), Log S (Al...
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CORRELATION OF THE LEVELS OF HIGH SENSITIVITY C-REACTIVE PROTEIN (hs-CRP) IN PATIENTS DIAGNOSED WITH METABOLIC SYNDROME
Objectives: Metabolic syndrome (MetS) is a cluster of several metabolic disorders including hyperglycemia, reduced high density lipoprotein cholesterol (HDL-C), raised triglyceride level in serum, hypertension and abdominal obesity. The independent risk factors of high sensitivity C-reactive protein (hs-CRP) levels may have a significant impact on evaluating the prevalence of MetS components in ...
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3D BIOPRINTING AND BEYOND: A TECHNOLOGICAL TRANSFORMATION FOR PHARMACEUTICAL AND BIOMEDICAL APPLICATIONS
3D Bioprinting is a transformational technology that is an indispensable part of the pharmaceutical and biomedical fields. It has been used globally as a cutting-edge tool to improve future prospects. This review encompasses a brief explanation of what exactly 3d bioprinting is, its processing, and how it differs from 3d printing. The elemental segment of bioprinting is bioinks which are biomateri...
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