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ENHANCEMENT OF BIOACTIVE CRUDE COMPOUND PRODUCTION BY STATISTICAL OPTIMIZATION OF FERMENTATION PARAMETERS FROM STREPTOMYCES SP. NLKPB45 ISOLATED FROM MARINE SOIL SEDIMENT
Actino bacterium Streptomyces sp. NLKPB45, which was isolated from mangrove soil sediments of Nellore coastal regions of Andhra Pradesh, India, was used in shake-flask fermentation to explore the different carbon and nitrogen substrates for antimicrobial crude compound. Careful experimentation of ranging each variable in the fermentation medium found that glucose and peptone as preferred carbon an...
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COMBATING THE EMERGING DRUG-RESISTANT PSEUDOMONAS AERUGINOSA BY AN ANTIBIOTIC PURIFIED FROM THE NOVEL STREPTOMYCES VIOLASCENS STRAIN VS
Aim: The emergence of drug-resistant pathogens enforces the isolation of potent and novel antibiotic-producing Streptomyces sp., from the undisclosed ecological niches. Methodology: Unique Streptomyces violascens strain VS isolated by serial dilution agar plate method and strain confirmed by 16S rDNA sequencing. Antibacterial assay against multidrug resistant Pseudomonas aeruginosa isolated from b...
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IN-VITRO INHIBITION AND DISSOLUTION OF CALCIUM OXALATE STONES BY THE FRACTIONS OF THE ZIZIPHUS LOTUS L. LEAVES
Nowadays, many clinical studies have provided reliable results on the effects of several herbal medicines on many diseases such as kidney problems. The objective of this study is to evaluate in-vitro the antiurolithiatic activity of polyphenols, flavonoids, and alkaloids fractions of the leaves of the species Ziziphus lotus. The quantification of the polyphenol and flavonoid fractions was carried ...
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A CROSS-SECTIONAL ANALYSIS OF HEALTH-RELATED MISLEADING ADVERTISEMENTS REPORTED BY SIDDHA REGIONAL RESEARCH INSTITUTE, PUDUCHERRY
Background: Misleading advertisements in the healthcare sector, particularly concerning Ayurveda, Siddha, Unani, and Homeopathy (ASU & H) products, pose significant risks to public health. Despite existing regulations, the prevalence of such advertisements remains a concern, necessitating comprehensive strategies for mitigation. Methods: This cross-sectional analysis examines misleading advert...
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NUTRITIONAL QUALITY UPGRADING OF INDIGENOUSLY DEVELOPED RICE MUTANT THROUGH EXPLORATION OF PHYTIC ACID AND AMYLOSE REGULATORY GENES
Phytic acid and amylose in rice food play an essential role in human health. The best-practiced approach is necessary for nutritional quality improvement of rice grain. The mutational breeding approach and chemical treatment are powerful methods to enhance rice quality by managing the concentration of phytic acid and amylose contents. The analysis of glycemic index and amylose contents is also sig...
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QUALITY OF LIFE OUTCOMES IN OBSESSIVE-COMPULSIVE DISORDER PATIENTS RECEIVING TREATMENT IN A NORTHERN INDIA TERTIARY CARE PSYCHIATRY OUTPATIENT DEPARTMENT
Background: Obsessive-Compulsive Disorder (OCD) is a chronic mental health condition that significantly impairs an individual’s quality of life (QOL), affecting physical, psychological, social, and environmental well-being. In India, particularly in Northern regions, OCD patients face unique socio-cultural and healthcare challenges, which may exacerbate the impact of the disorder. This study aim...
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SYNTHESIS OF BIOACTIVE MONONUCLEAR COPPER (II), NICKEL (II), COBALT (II) AND MANGANESE (II) SCHIFF BASE COMPLEXES DERIVED FROM ISATIN: ANTIOXIDANT, ANTI-BACTERIAL AND DNA CLEAVAGE ACTIVITIES
Potentially bioactive tetradentate novel Schiff base ligand and its mononuclear metal (II) complexes have been synthesized by the condensation method of p - nitroaniline, isatin, and 2, 2′ bipyridyl molecules in the ratio of 1:1:1. The ligand and its reported complexes exactly categorized by diverse physicochemical techniques that include elemental analysis, conductance measurements, IR, electro...
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POTENTIAL OF PLECTRANTHUS AMBOINICUS AND OCIMUM SANCTUM PHYTOCONSTITUENTS AS ANTIVIRAL AGENTS AGAINST SARS-COV-2: AN IN-SILICO INVESTIGATION
Background: The infectious disease, COVID-19, caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), is hardly showing signs of waning as it is still ongoing as a pandemic. Objective: To figure out potential leads from Ocimum sanctum and Plectranthus amboinicus’s phytoconstituents against SARS-CoV-2. Methodology: Selected phytoconstituents of O. sanctum and P. amboinicus were ta...
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EXTRACTION ISOLATION CHARACTERIZATION AND PHARMACOLOGICAL SCREENING OF AEGLE MARMELOS FOR ANTIASTHMATIC ACTIVITY
Aegle marmelos (L) Correa also known as Bale, belongs to family Rutaceae. The plant is used to treat several diseases like bronchitis, asthma, malarial, astringent, laxatives, digestive and febrifuge. Leaves are used as antipyretic, antimicrobial, antidiabetic, antihistaminic, anti-inflammatory, antioxidant, and hyperlipidaemic activity. The plant contains diterpenoids, triterpenoids, and phenolic...
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AN EFFICIENT METHOD FOR ANTHER AND OVARY CULTURE IN ABELMOSCHUS ESCULENTUS (L.) MOENCH. IN-VITRO
Okra (Abelmoschus esculentus (L.) Moench.) is an important nutrient-rich vegetable crop also known as “lady’s finger”, widely grown in the tropics and sub-tropics mainly for its edible pods and is an alloploid. The haploid technique has been used in plant breeding for the improvements of plants and to develop new varieties in a relatively short time. Hence, we have optimized several factor...
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