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PERIUMBILICAL PERFORATING PSEUDOXANTHOMA ELASTICUM: A RARE CASE REPORT WITH A DISTINCTIVE PRESENTATION
Periumbilical perforating pseudoxanthoma elasticum (PPPXE) presents as well-defined, yellowish, atrophic plaques encircling keratotic papules, often observed in obese, multiparous women. This dermatosis is considered either a localized acquired cutaneous disorder or a variant of hereditary pseudoxanthoma elasticum. We report a case clinically diagnosed with differentials but confirmed as PPPXE thr...
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IN-VITRO ANTIMICROBIAL ACTIVITY OF CURCUMA AMADA ON THE CLINICAL ISOLATES OBTAINED FROM BURN’S WOUND
The increasing resistance of microorganisms to conventional antibiotics has prompted scientists to explore alternative sources for antimicrobial compounds. This study focuses on Curcuma amada, a perennial herb, and its rhizome extracts for antibacterial activity against major bacterial strains identified in burn wounds: Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, and Pseudomona...
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RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF TEPOTINIB IN PRESENCE OF ITS IMPURITIES IN A TABLET DOSAGE FORM
A simple, rapid, precise, sensitive and reproducible Reverse phase high performance liquid chromatography (RP-HPLC) method has been developed for the quantitative analysis of Tepotinib in presence of its impurities (1&2) in pharmaceutical dosage form. Chromatographic separation of Tepotinib and its known impurities were achieved on Waters Allianace-e 2695 by using Inertsil ODS C18 250x4.6mm 5Â...
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AN EXPERIMENTAL STUDY TO EVALUATE THE POTENTIATING EFFECT OF SELENIUM, ZINC, VITAMIN C AND VITAMIN E AS SUPPLEMENT TO SULFONYLUREAS ON STREPTOZOTOCIN INDUCED DIABETIC RATS
Objectives: To study potentiation of hypoglycaemic effect of Glimepiride with combination of Selenium, Zinc, Vitamin C and Vitamin E on Streptozotocin induced diabetic rats and to compare potentiating hypoglycaemic effect of above-mentioned drugs with that of standard diabetic control group. Methods: Study was carried out in Research Laboratory, Department of Pharmacology, BIMS, Belagavi. Albino r...
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EVALUATION OF HYPOGLYCEMIC EFFECT AND PHYTOCHEMICAL CONSTITUENTS OF VERNONIA AMYGDALIN DEL. FAM. ASTERACEAE
Purpose: Leaf of Vernonia amygdalin Del Fam. Asteraceae has been shown to have hypoglycemic activity. This work was designed to identify the secondary metabolites present in the plant leaf, test their lethality, and then determine the best solvent system for their extraction. Methodology: One kilogram of crushed leaves of the plant Vernonia amygdalin was extracted with 5.0 L of methanol using Sohl...
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