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ASPARTAME CONSUMPTION IN DIABETES MALE ALBINO RATS – COMPLICATIONS IN BRAIN ANTIOXIDANT SYSTEM
The present study investigated the effect of intake of aspartame in diabetic rats, a widely used artificial sweetener (aspartame), on antioxidant defence status in the rat brain. Adult male Wistar rats weighed 180 ± 20 gm were randomly divided into 4 groups as follows: The first group was control; the second group was given aspartame (ASP) at a dose of 50 mg/kg body weight; the third group was Di...
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IN-SILICO HOMOLOGY MODELING OF CRUSTIN PROTEIN IN PORTUNUS TRITUBER-CULATUS CRAB SPECIES
The aim of the present In-silico studies is to find out the potential protein target and find out the 3D structure of crustin antimicrobial protein in Portunus trituberculatus. Crustin are small cationic proteins assumed to be antimicrobial effectors against mainly Gram-positive bacteria. The swimming crab Portunus trituber-culatus is a commercially important crab species in East Asia countries...
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CELLULOSE ETHER HYDROGELS AS POTENTIAL CARRIERS FOR PULSATILE DRUG DELIVERY SYSTEM
Hydrogels are cross-linked polymers with the capacity to bulge in an aqueous medium. Because of their extraordinary properties, these are utilized as brilliant drug delivery vehicles that particularly necessitate focusing on the drug to specific sites. On account of the eminent hydration and biocompatibility properties generally utilized in pharmaceutical field, especially cellulose derivatives. I...
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FOCUSING ON THE RECENT PROGRESS IN ANTIMICROBIAL POTENTIALS OF PLANT EXTRACTS-MEDIATED SYNTHESIZED SILVER NANOPARTICLES
Using plant extracts to synthesize metal nanoparticles is one of the easiest, most convenient, cost-effective, and ecologically acceptable ways of avoiding hazardous chemicals. As a result, many environmentally acceptable methods for the fast production of silver nanoparticles utilizing aqueous extracts of plant components such as leaves, bark, and roots have been described in recent years. This s...
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EFFECTIVENESS OF A STRUCTURED EDUCATIONAL INTERVENTION ON KNOWLEDGE, ATTITUDE AND PRACTICE OF PHARMACOVIGILANCE AMONG NURSES
Background: Globally used modern medicines cause various adverse drug reactions (ADR). In order to improve patient safety and welfare, and to reduce patient morbidity and mortality, spontaneous ADR reporting is the need of the hour. Nurses are the first point of contact with patients in any hospital, so their awareness is important to improve the practice of pharmacovigilance. Objectives: To asses...
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A REVIEW ON MANAGEMENT OF CARDIOVASCULAR DISEASES BY HERBAL NANOPARTICLES
Cardiovascular diseases (CVDs) are related to heart and blood vessel disorders. The changing lifestyles of unhealthy diets, physical inactivity, and tobacco and alcohol consumption have increased the risk factors of heart diseases. A literature search reveals that the rise in risk of CVD’s is higher after a SARS-COV2 infection. Also, CVDs independently are one of the leading cause of death globa...
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OPHTHALMIC DRUG DELIVERY SYSTEMS FOR CONJUNCTIVITIS
Ophthalmic drug delivery is greatly onerous for a better remedial response in any type of disease state for instance, conjunctivitis, more commonly published as pinkeye, is an inflammation of the conjunctiva, a clear membrane that envelopes the outmost lamina of the eye and the inside surface of the eyelids. Usually, conjunctivitis is of the following classes depending on their origins of contagio...
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METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF ITRACONAZOLE AND TERBINAFINE HCL IN BULK AND PHARMACEUTICAL DOSAGE FORM BY USING UV VISIBLE SPECTROSCOPY
In this present study, a simple, effective, and accurate method has been developed for estimating itraconazole and terbinafine in bulk and pharmaceutical dosage form using UV Visible spectrophotometer. Two methods were developed: the simultaneous equation method, also known as vierordt’s method, and the other absorbance ratio method, also known as Q value method. In the simultaneous equation met...
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INSIGHTS INTO VARIOUS NOVEL SYNTHETIC STRTAEGIES FOR FLAVONE DEVELOPMENT: PHARMACOLOGICAL IMPORTANCE
Flavones make up one of the biggest subgroups of the secondary metabolite class of flavonoids, which has more than 9000 known structural variations. It is shown that they are present in practically all plant tissues naturally. In the literature, many flavone aglyca and their O- or C-glycosides have been described. Numerous potential uses exist for flavones due to their wide range of biological act...
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A SIMPLE METHOD DEVELOPMENT, VALIDATION AND QUANTIFICATION OF LENVATINIB IN PHARMACEUTICAL DOSAGE FORM USING ZERO ORDER AND FIRST-ORDER DERIVATIVE NOVEL SPECTROPHOTOMETRIC METHODS
Simple, very Sensitive, rapid, and accurate novel spectro-photometric methods were developed to estimate Lenvatinib in Pharmaceutical dosage form using zero- and first-order derivative spectrophotometry. The solutions of Lenvatinib standard and sample were prepared using analytical grade methanol. The spectrophotometric estimation of lenvatinib was carried out at 240 nm in the zero-order method an...
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