Posted by admin on Oct 31, 2015 in |
Rapanea ferruginea Mez. stem barks and fruits extracts have demonstrated anticholinesterasic and antimicrobial activities assigned to myrsinoic acids A and B (MAA and MAB), compounds that have also proven anti-inflammatory and antinociceptive activities. To stablish the quality control of nanotechnology-based herbal medicines, the aim of this study was develop and validate a stability indicating HPLC–DAD method for quantitative analysis of MAA and MAB markers in R. ferruginea stem barks and fruits extracts and nanoemulsions. Chromatographic separation was conducted on a Kinetex®C18 column (150 x 4.6 mm x 2.6 µm), with mobile phase consisted of acetonitrile: methanol: water (acidified with H3PO4 pH 2.50) and eluted in gradient mode with flow rate of 0.9 mL min-1, with 30 min of analysis and detection at 260 nm and 270 nm. The method was specific, linear, sensitive, accurate and robust for both markers. The chromatograms of stem barks and fruits extracts submitted to forced degradation study (acid, oxidative, UV and visible light) did not show impurities interference in MAA and MAB quantification, therefore,...
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Posted by admin on Oct 31, 2015 in |
Background: Hepatic encephalopathy (HE) is a brain dysfunction caused by liver insufficiency and/or portosystemic shunting. It is associated with poor survival and high risk of recurrence along with reduced quality of life (QOL) of patients and their caregivers. Nitazoxanide (NTZ) is an oral antimicrobial that improved mental status and QOL score in HE patients and is well-tolerated. Aim: To evaluate the efficacy and safety of NTZ compared to metronidazole and rifaximin in patients with grade II-III HE and to evaluate its effect on patients’ QOL. Patients and Methods: A Prospective, Randomized, Controlled, Open-Label, Pilot study. Thirty four patients were randomly assigned to receive either Nitazoxanide (n=12), Metronidazole (n=11) or Rifaximin (n=11) for 7 days. Serum ammonia level, Clinical Hepatic Encephalopathy Staging Scale (CHESS) and Chronic Liver Disease Questionnaire (CLDQ) for QOL was measured at baseline and at end of treatment. Results: Baseline and after 1 week serum ammonia levels and CHESS scores, showed no significant difference among the 3 groups. There was no significant difference in serum ammonia level...
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Posted by admin on Oct 31, 2015 in |
The study was aimed to investigate the activity of hydroalcoholic extract of Cucumis sativus in gastric ulcerated rats. Anti ulcer activity was evaluated via oral administration of HACS at the dose 250, 500 and 1000mg/kg thrice in a day for 5 days before pyloric ligation ulceration, indomethacin and ethanol induced ulceration. Various parameters such as ulcer index, gastric volume, pH of gastric juice, total acidity, estimation of total proteins, total carbohydrates, total hexoses, hexosamine, fucose, salic acid and histopathological parameters were studied in the control group and pretreated groups with hydroalcoholic extract of fruit pulp of Cucumis sativus and standard drug ranitidine. In indomethacin, ethanol and pyloric ligation model, the pretreatment with HACS and ranitidine significantly reduce the ulcer index, free acidity as compared with controlled group. The % protection of ulcers were evaluated. The extract showed significantly (P<0.05) increase in pH with significant decrease in volume of gastric juice, free and total acidity. Histopathological findings also confirm the antiulcer activity of Cucumis sativus fruit pulp extract in albino...
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Posted by admin on Oct 31, 2015 in |
A series of Oxadiazole derivatives (4a-d) have been synthesized from (2, 4, 5-triphenyl-imidazole-1-yl)-acetic acid hydrazide under various reaction conditions. Elemental analysis, IR, 1H NMR and mass spectral data confirmed the structure of the newly synthesized compounds. All the synthesized Oxadiazole derivatives have been investigated for their anti-fungal and antimicrobial activity showing moderate to good activity. The anti-fungal activity of the newly synthesized compounds was compared with the standard drug Voriconazole. The oxadiazole derivatives showed moderate to good ant-fungal activity. The compounds having 4-methoxy group showed good activity (81%). The Oxadiazole derivative having 4-flourophenyl group showed highest activity (82.14%). The results of anti-microbial and anti-fungal activity clearly indicated that oxadiazole ring bearing 2, 4, 5-triphneylimidazole have moderate...
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Posted by admin on Oct 31, 2015 in |
The present study investigated total carotenoid content of twelve mango varieties of Bangladesh. Change in the total carotenoid content at various stages of maturity was also determined. Carotenoids are bioactive substances in food with powerful antioxidant activity. It has role in enhancement of the immune response and reduction of the risk of degenerative diseases such as cancer, cardiovascular diseases, cataract and macular degeneration. Mango is the leading seasonal cash crop of the northwestern region of Bangladesh. The mango (Mangifera indica) (Bangla- aam) is the king of fruits in Bangladesh. It’s a fleshy stone fruit. Mango is generally very sweat and tasty common fruits in Bangladesh. It’s also one of the most popular fruits in the world. Total carotenoid content in twelve mango varieties was analyzed by solvent extraction method followed by spectrophotometric method. Mangoes contain different amount of total carotenoid in green, semi-ripe and ripe stages. Carotenoid content in green mango was 3.09 μg/100m while that of semi-ripe mango was 70.875 μg/100gm and ripe mango was 251.74 μg/100gm. Among...
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