Posted by admin on Oct 31, 2015 in |
The aim of the present study is to evaluate the protective effect of flower extract of Michelia champaca on membrane bound enzyme (serum ATPase) levels on male albino rats. The membrane bound enzymes (Ca2+ ATPase, Mg2+ ATPase, Na+K+ ATPase) levels of methanolic flower extract of Michelia champaca at a dose of 300 mg/kg was evaluated during exposure to CCl4. There was a significant decrease in membrane bound enzymes such as Ca2+ ATPase, Mg2+ ATPase, Na+K+ ATPase was observed in CCl4 treated rats. Therapeutic treatment with plant extract has significantly ameliorated to near normalcy in the curative group. These results of the study concluded that Michelia champaca was found to be effective in preventing the biochemical abnormalities caused by...
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Posted by admin on Oct 31, 2015 in |
Montelukast sodium is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies1-2. Montelukast comes as a tablet, a chewable tablet, and granules to take by mouth3. Montelukast is usually taken once a day with or without food3. The present study describes a simple, accurate reproducible and precise uv spectrophotometric method for the estimation of Montelukast Sodium in bulk and in tablet dosage form. The absorbance maxima (λmax) for Montelukast Sodium were found to be 286.5nm. The method was validated for different parameters such as molar absorptivity, accuracy precision, ruggedness, robustness, detection limit, quantification limit etc, (as per ICH guidelines). The relative standard deviation (RSD) in case of, accuracy precision, ruggedness, robustness was less than 2.0% proving that method was highly accurate, precise and robust. This method can be used for determination of Montelukast Sodium in pharmaceutical formulations without interference of the...
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Posted by admin on Oct 31, 2015 in |
The core finding of the present preclinical study demonstrated that, administration of increasing doses of Agmatine is remarkably neuroprotective in male wistar rats against 6-Hydroxydopamine induced neurotoxicity. Parkinson’s disease (PD) is a chronic and progressive neurodegenerative disease with multiple motor and non-motor features that contribute to the impairment of health-related quality of life (QOL). It is associated with the loss of brown pigment neuromelanin with preferential loss of the dopaminergic neurons of the substantia nigra pars compacta results in oxidative stress and mitochondrial dysfunction. It is characterized by reduced movement, rigidity, and tremor. Agmatine (AGM) (1-Amino-4-guanidinobutane, 4 (Aminobutyl) Guanidine,1- guanidinobutane) pharmacological and electrophysiological evidence indicate that Agmatine act at N-methyl-d-aspartate (NMDAr) and nitric acid synthase (NOS) to exert anti-excitatory effects throughout the central nervous system. Agmatine act as neuroprotective agent & memory enhancer. Relevent doses of Agmatine treatment protects behavioural changes, significantly attenuated oxidative damage & improved mitochondrial complexs enzyme activities in different regions (striatum, cortex and hippocampus) of rat brain against 6-OHDA induced neurotoxicity. I.C.V. administration of 6-Hydroxydopamine is...
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Posted by admin on Oct 31, 2015 in |
Objective: The objectives are to assess the drug dose administration and reduce the dose toxicity in geriatric patients. Method: A Prospective interventional study has been carried out on drug dose administration in geriatric patients with respect to creatinine clearance rate at a tertiary care hospital for about 6 months. A total number of 204(47 baseline+157study) geriatric patients are included who has attended the general medicine ward. Results: In our study, we observed that Creatinine clearance was decreased as age increases. In study population 60-65yrs (48.6ml/min) was more, in 80-85yrs (29.2ml/min) was less and also similar in baseline study. So we can understand that geriatrics has a moderate renal failure. In a baseline among 47 subjects, 53% require dose modifications. In baseline 11 (44%) subjects experienced adverse drug reactions. Mostly Augmented types of adverse effects were observed. Among 157 study population, 28% were undergone dose modification by the suggestion of a pharmacist. It was observed that in 31 (70.4%) dose of the drug was reduced, in 6(13.6%) dose interval was...
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Posted by admin on Oct 31, 2015 in |
The manuscript devoted to investigation of some patterns of the mode of action of retabolil, compound LES-2222 (new thiopyrano[2,3-d]thiazole derivative (2-(2-Oxo-5a,11b-dihydro-5H,6H-7-oxa-1,4-dithia-3-aza-cyclopenta[c] phenanthren-3-yl)-N-(3-trifluoromethyl-phenyl)-acetamide) – synthesized at the Department of Pharmaceutical, Organic and Bioorganic Chemistry) and testosterone in rats under food deprivation. The changes of the activity of antioxidant enzymes – glutathione peroxidase (GPO) and catalase (CAT) were investigated in the different tissues under food deprivation and compounds treatment. The effects of all tested compounds were similar. The GPO activity decreased under the LES-2222 application in the liver and kidney and was increased in spleen and testes, but in the myocardium and skeletal muscle its level was normalized. Testosterone and retabolil treatment did not change the GPO activity in the liver and spleen. While, the decrease of activity level in kidney and skeletal muscle and normalisation in the myocardium and testes were detected. The changes of CAT activity under the tested compounds action were noticeable, but not statistically significant in the liver and testes. Significantly increased level of CAT activity in...
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