Posted by admin on Aug 31, 2015 in |
Cotylophoron cotylophorum, the parasite of ruminants cause a disease called paramphistomosis. Paramphistomosis in domesticated ruminants cause considerable economic loss to the livestock industry in India. In the present study, the anthelmintic activity of Terminalia chebula was assessed based on its effects on the motility and acetylcholinesterase (AChE) of the digenetic trematode C. cotylophorum in vitro. The flukes were exposed to five different sub-lethal concentration of ethanol extract of Terminalia chebula (TcEE) for 2, 4 and 8h. The motility response of the drug-treated parasites was recorded with the aid of Electronic micromotility meter (EMM). Acetylcholinesterase (AChE) activity of the C. cotylophorum was assayed following standard method. The maximum inhibition of motility and AChE activity was observed at 0.5 mg/ml concentration after 8 h of exposure. Inhibition of AChE activity increased with an increase in the drug concentration and the period of exposure. AChE is an enzyme involved in neurotransmission. The ethanol extract of Terminalia chebula (TcEE) inhibits the AChE and affect the motor activity of the parasites, thus the parasite...
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Posted by admin on Aug 31, 2015 in |
Emblica officinalis and its derivative (Ascorbic acid) have profound effect on development and regeneration and are widely used in the Indian System of medicine for the treatment of different type of disease. Here, we discussed the comprehensive account of the effect of aqueous extract of the fruit of E.officinalis with special reference to cardiac tissue regeneration in frog tadpoles. E.officinalis was found to be a good model to accelerate regeneration ability of infracted cardiac cells which further give rise to intact cardiac part (intact ventricle part) in all mode of experiment employed i.e insitu (in vivo), in transplantation setup and in culture medium. The most spectacular case was rhythmic beating of implanted cardiac tissue at ectopic site of tail of E.officinalis treated tadpoles. The E.officinalis supplemented cultures were also appeared to be a suitable for investigating the changes occurred during regeneration and differentiation of cardiac...
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Posted by admin on Aug 31, 2015 in |
In the present work, a prodrug (2) of aceclofenac was synthesized using N-hydroxymethylisatin (1) as promoiety. Its structure was established on the basis of modern analytical techniques. An analytical, rapid, cost-effective and accurate method using UV-spectroscopy has been developed for the synthesized prodrug. The results and calibration curves obtained with different solvents for the prodrug revealed that the method developed was precise and...
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Posted by admin on Aug 31, 2015 in |
To investigate the effects of ginger-juice (Zingiber Officinale Roscoe) on rat’s intestinependular motility. Methods: Albino rats were sacrificed to isolate intestine. Concentration of ginger is expressed in term of mg/ml of ginger rhizome. It is based on preparation of ginger-juice as detailed in material and methods section. 150 ml of filtrate used in the isolated experiment represented 500 gm of ginger rhizome. The diluted filtrate was used in the “in vitro” experiment. Result: G.J.F produced significant pendular motility in isolated rat...
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Posted by admin on Aug 31, 2015 in |
Research with plants and plant derivatives are increasing day by day for the discovery of therapeutic and nutraceutical agents from them and due to the versatile applications of those beneficial agents. The present study was thus designed to investigate the antioxidant and cytotoxic properties of methanolic Averrhoa carambola L. fruit extract along with the identification of the phytochemicals present in the extract. The antioxidant activities were determined by several assays: determination of total phenol content, assessing total flavonoids content, total antioxidant capacity assay and DPPH free radical scavenging assay. The in-vitro cytotoxic activity of fruit extract of Averrhoa carambola L. was determined by Brine Shrimp Lethality assay (BSLA). Preliminary phytochemical screening confirmed the presence of alkaloids, flavonoids, phenolics, carbohydrate, saponin, tannin in the methanolic extract of Averrhoa carambola L. fruit which was indicative of possible antioxidant and cytotoxic activity. The extract showed good antioxidant activities having total phenol content of 21.316±0.372 mg GAE/gm, total flavonoid content of 23.058±2.059 mg QE/gm, total antioxidant capacity of the extract was 152.368±2.791 mg...
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