Posted by admin on Jul 31, 2015 in |
Bhasmas, the formulations, which can be prepared from metals, minerals or even some marine products, are being used in Ayurvedic system of medicine. Copper (Tamra) is one such metal, used to prepare a bhasma, called “Tamra Bhasma” (TB) which is claimed to cure various diseased conditions. Though bhasmas are prepared since centuries, the exact mechanism of conversion of metal to its bhasma, especially by the use of modern scientific tools is not established. Here is an attempt to prepare TB as per the text “Ayurved Sar Sangraha” and analyze the stepwise changes in terms of chemistry. TB was prepared from the copper wires. Steps involved in the preparation were shodhan, maran and post maran treatment. Raw materials, intermediates and finished product were analyzed as per Ayurvedic pharmacopeia. Modern scientific techniques such as XRD, XPS and SEM were employed to assess the changes taking place during the steps of preparation and thus characterization of the intermediates and finished drug was accomplished. Chronological study of TB preparation, showed that conversion of...
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Posted by admin on Jul 31, 2015 in |
Molluscs as a second largest phyla includes snails, slugs, clams, oysters, scallops, cuttlefish, squid and octopus. Present study revealed, diversity of molluscan fauna from three sites i.e Khanderajuri lake, Mhaishal lake and Krishna river in the period of January, 2011 to December, 2013. Among collected molluscs 10 species were identified from seven families i.e. Physidae, Lymnaeidae, Viviparidae, Corbiculidae, Thiaridae, Planorbidae and Littorinidae included in class Gastropods and Bivalve. Seasonal variations showed quantitative difference in gastropods, Quantity was observed to be minimum in mansoon season as compared to premansoon and postmansoon season. Physicochemical alterations were showed influence on the biodiversity at the various...
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Posted by admin on Jul 31, 2015 in |
The present work focuses on treatment of glaucoma by formulating ocular inserts of different polymeric combination and Betaxolol to enhance therapeutic effect through prolonging contact time with corneal surface, Betaxolol is a cardio selective (β1 adrenergic) receptor blocking agent. Ophthalmic betaxolol may be especially useful in the treatment of glaucoma in patient with pulmonary disease. Sustained drug therapies have more advantages than conventional. In the present study, an attempt was made to formulate sustained drug delivery system films for Betaxolol. In matrix type formulations for Betaxolol containing 10%, 12%, and 14% w/v of HPMCK4m and 14%, 16% and 18% w/v for Ethyl cellulose were Prepared by solvent casting method. And evaluated for their average weight variation, thickness, Drug content, In-vitro drug release and stability studies. An increase in average weight and thickness is due to increase in polymer concentration. IR spectral studies were performed to confirm the interaction of drug with excipients. IR spectrum revealed that there is no compatibility and no drug interaction. In vitro drug release Studies...
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Posted by admin on Jul 31, 2015 in |
The present study is to investigate the cytotoxicity properties and haematological indices of synthesized molecules (S1-S4) in comparison to the standard drug 5 fluorouracil which reflects the anticancer potentials of the above molecules. Cytotoxicity studies were performed by in vitro MTT (3-(4, 5-dimethylthiazol-2-yl)-2, 5- diphenyl teterazolium bromide) assay. Haematological studies were done by drawing blood in the drug and synthesized molecules administered animals by retroorbital method. Haemoglobin, RBC, WBC, lymphocytes, Monocytes and Granulocytes counts were measured. All the above experiments were performed against Ehrlich ascites carcinoma (EAC) in Swiss albino mice. The percentage cytotoxicity and percentage viable cell counts revealed anticancer properties of the synthesized molecules. RBC count indicated protection of cell membrane from destruction and the WBC counts along with lymphocytes, Monocytes and granulocytes also show the immunoprotective characteristics of the novel molecules. Thus it has been concluded that the synthesized molecules (S1-S4) if supported by further molecular studies may have a promising role to play as anticancer...
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Posted by admin on Jul 31, 2015 in |
Medicinal plants have been investigated for possible anti-cancer effects. Corallocarpus epigaeus (Roth & willd.) cl. is an ethnobotanically important wild climber that belongs to the family Cucurbitaceae. The aim of the present study is to examine the cytotoxic activity of Corallocarpus epigaeus (Roth & willd.) cl., on two tumor cell lines. The methanolic root extract of the plant Corallocarpus epigaeus (Roth & willd.) cl. was subjected to cytotoxic activity study against two human cancer cell lines (MCF7, human breast adenocarcinoma and HT-29, human colon carcinoma) using the MTT assay. The concentration of methanolic root extract yields the IC50 value of 183.33±0.7 µg/ml and <62.5µg/ml respectively for HT-29 and MCF-7 cell lines by MTT assay. The results showed that the root extract of Corallocarpus epigaeus has potential anti-cancer activity against MCF-7 and HT-29 human cancer cell...
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