Posted by admin on Sep 30, 2015 in |
The objective of the present investigation was to improve dissolution characteristics of febuxostat, a BCS class – II drug, by formulating it as solid dispersion adsorbate. Solid dispersion adsorbate(SDA) was prepared using labrasol, transcutol and lutrol F127 as carriers and neusilin as adsorbent. Formulation was prepared using combination of melt and adsorption technique. Optimized formulation was characterized by fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC) and X-ray diffraction (XRD). In-vitro dissolution profile was compared with the marketed product. SDA comprising of febuxostat, neuslin and the three carriers in a ratio of 1:2:4 was considered as optimized formulation. FTIR spectroscopy revealed intermolecular hydrogen bonding with neusilin. DSC scan showed absence of melting peak of febuxostat, which indicates solubilization of drug in carriers and conversion of crystalline to amorphous form. This point was further confirmed by XRD. The percentage yield obtained was 90% and there was 10% increase in the dissolution rate of the optimized formulation compared to the marketed product. The dissolution efficiency was found to be 37%...
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Posted by admin on Sep 30, 2015 in |
Ganoderma lucidum (Fr.) Karst., known as medicinal mushroom and it contains several bioactive phytochemicals such as polysaccharides, nucleosides, alkaloids, coumarin, ergosterols, ganoderic acids, lactones, mannitol, organic germanium, triterpenoids, unsaturated fatty acids, vitamins and minerals which are well known for their pharmacological properties. In the present investigation adenine, adenosine and uracil content of the aqueous and alcoholic lyophilized extract of dried G. lucidum powder of Indian Himalayan Region (IHR) were determined by HPTLC. Further, phytochemical analysis (total polyphenols, total flavonoids, reducing power, antioxidant potentials), antioxidant and antimicrobial efficacy of both extracts against pathogenic strains like Vibrio cholerae, methicillin resistant Staphylococcus aureus, Bacillus subtilis and Bacillus cereus was also evaluated. The adenine, adenosine and uracil content of aqueous extract was found to be higher than the alcoholic extracts. Both extracts were identified as rich source of flavonoids, polyphenols, reducing power and antioxidants. A significant antimicrobial activity was observed in both the hydro alcoholic and aqueous extract against all the pathogenic strains tested with MIC value of 2-4 mg/ml for the hydro...
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Posted by admin on Sep 30, 2015 in |
The aim of the present study was to implement QbD approach to identify, evaluate and control critical process and formulation parameters and their impact on critical quality attributes (CQAs) and to establish design space with multifactorial combination which would provide high degree of assurance to achieve quality target product profile (QTPP). A risk assessment was performed with various process and formulation parameters to determine their impact on particle size and encapsulation efficiency (CQAs) of nanoparticles and further high risk parameters were optimized using I-Optimal design. Design space was generated by setting limits to CQAs as per acceptance criteria of Tacrolimus loaded PLGA (TC PLGA) nanoparticles. The optimized formulation from design space was further characterized by XRD, DSC, SEM, in-vitro dissolution study. The nanoparticles obtained were free flowing, spherical, smooth and uniform. In-vitro dissolution study showed ability of nanoparticles to sustain drug release for period of 4 weeks. In conclusion, it can be demonstrated that, QbD approach was successfully implemented for understanding of process and formulation parameters and further develop...
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Posted by admin on Sep 30, 2015 in |
A 20-year-old male patient reported to ophthalmology outpatient department with complaint of loss of vision in right eye since childhood and diminished vision in left eye for 1month of duration. Funduscopy revealed right side optic atrophy and left sided vitreous hemorrhage. Non-contrast computed tomography study of head showed hyperdense circle of Willis and cerebral venous sinuses. No contrast was given before the computed tomography scan of head. Bilateral orbit showed right sided oval enlarged eye ball with medial deviation and normal left eye ball. Magnetic resonance venography was advised to rule out sinus venous thrombosis which revealed normal study of sinuses. On clinical examination, the patient had clubbing of all fingers, mild cyanosis, hyperemia of lower conjunctiva and systolic murmurs on auscultation with raised hematocrit level (72 percentage). Echocardiography of the patient showed features of tetralogy of Fallot (TOF). The hyper-dense vessel was due to raised hematocrit (secondary polycythemia Vera)...
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Posted by admin on Sep 30, 2015 in |
Background: Snake bite is a problem across the developing countries, where agriculture is one of the main sources of income and India is one among it. Objective: The study was carried out to determine the pattern of snake bite in four different selected tertiary care hospitals of south India for a period of 03 years from March 2011 to March 2014. Material and Methods: A prospective observational study of 270 patients of snake bite was collected in patients admitted to emergency department in four different selected tertiary care hospitals in south India. Patients with history of previous visit for treatment before admitting into the study sites were excluded from the study. Results: There were 201 males [74.4%] and 69 females [25.5%] out of 270 snakebite patients in our study. Of that, 142 [52.6%] patients were between the age group of 30-50 years. Most of the cases were farmers [56.66%] and Laborers [32.96%]. Peak incidence of snake bite was observed during rainy season [68.8%]. Most of the envenomation had reported...
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