Posted by admin on Sep 30, 2015 in |
Addicted smokers Semen analysis from a cross section of population of Anantapuramu district, Andhra Pradesh, India was done as it provides a useful profile of the function of the male reproductive health. Seventy two (72) men were drown from a cross section of smokers and divided in to two age groups namely 25-30 years and 31-40 years. In both age groups persons were selected basing as how many cigarettes they smoked in a day. Different semen parameters like volume, liquefaction, alkalinity, sperm count, motility and morphology were analysed. Incidences of Hypospermia in 25, Teratozoospermia in 27, Oligozoospermia in 54, Oligoasthenozoospermia in 20, and Oligoasthenoteratozoopermia in 6 persons were observed. Abnormalities were seen in both age groups and in persons who smoke either moderately or...
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Posted by admin on Sep 30, 2015 in |
In Present study the antinociceptive and the gastroprotective effects of orally administered or inhaled Thevetia peruviana Pers. K. (Schum) (Oleander) volatile oil, and its principal constituents linalool and 1,8-cineole were evaluated in mice. Either when orally administered (100µl/kg) or inhaled for 60 min Thevetia peruviana volatile oil significantly reduced the acetic acid-writhing response in a naloxone-sensitive manner. In the hot plate test, analgesic activity observed after oil inhalation was inhibited by naloxone and atropine sulphate pretreatment suggesting the involvement of opioidergic as well as cholinergic pathways. Regardless of the administration route and the experimental model used both linalool and 1,8-cineole did not produce significant analgesic response. Oral or inhalatory treatment with analgesic doses of volatile oil did not affect mice spontaneous locomotors activity. Concerning the gastric effects, Oleander oil, linalool and 1,8-cineole oral administration protected against acute ethanol-induced gastric ulcers but did not prevent indomethacin-induced lesions indicating no interference with arachidonic acid metabolic cascade. In conclusion, besides this gastroprotection, Oleander oil reveals an interesting analgesic activity mainly relevant after...
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Posted by admin on Sep 30, 2015 in |
Heterocyclic compounds containing triazole ring are important targets in synthetic and medicinal chemistry because this key moiety in responsible for numerous biological activity. An efficient method for synthesis of novel derivatives of Substituted-1,2,4-triazolo phenyl quinolone was adopted by reacting various substituted aniline and cinnamic acid. The synthesized derivatives were designed to have an electron donating and electron with drawing groups to figure out which group is influencing probable pharmacological activity. During designing of the scheme the site of action for activity i.e. disruptions of bacterial cell wall in case of bacteria and interfering with enzymes (cytochrome p450) required for cell membrane synthesis for fungal inhibition was targeted. The structures of these newly synthesized compounds were established by their Elemental analysis, IR, 1H NMR and Mass spectral data. All the synthesized compounds were then evaluated for their antimicrobial potentials using standard drug fluconazole and clotrimazole for antifungal activity and ampicillin anhydride for antibacterial activity. Moderate to good antimicrobial activity was presented by the targeted final derivatives (3a-3j) against pathogenic fungal...
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Posted by admin on Sep 30, 2015 in |
Nephropathy is an important comorbidity associated with diabetes leading to chronic kidney disease. We studied the effect of Ocimum sanctum in comparison to Olmesartanmedoxomil, Pitavastatin and their combination in prevention of this comorbidity. Male Wistar rats were given streptozotocin to induce diabetes and randomly divided into groups. Group 1 (Control group) received Metformin (94.5mg/kg/day)+Distilled Water, Group 2 received Metformin (94.5mg/kg/day) +Ocimum sanctum (250 mg/kg/day), Group 3 received Metformin (94.5mg/kg/day) + Olmesartanmedoxomil(1.80 mg/kg/day), Group 4 received Metformin (94.5mg/kg/day) + Pitavastatin (0.18 mg/kg/day) and Group 5Metformin (94.5mg/kg/day) + Olmesartanmedoxomil (1.80 mg/kg/day) + Pitavastatin (0.18 mg/kg/day). The effects of Metformin alone and with Ocimum sanctum, Olmesartanmedoxomil, Pitavastatin and their combination on blood glucose and renal function test parameters were assessed. All groups showed decrease in fasting plasma glucose and glycosylated hemoglobin. Serum urea and creatinine were increased in the Control group. However, significant improvement in all the parameters studied were seen when Ocimum sanctum, Olmesartan or Pitavastatin were added. Histopathological examination of kidney showed mesangial proliferation, tubular swelling, thickened glomerular basement membrane,...
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Posted by admin on Sep 30, 2015 in |
Solubility is considered as the important parameters to achieve desired concentration of drug in systemic circulation for achieving required pharmacological response. Olmesartan medoxomil (OLM) is poorly soluble belongs to BCS class II. The drug is rapidly absorbed following oral administration, with a bioavailability approximately 26%. Liquisolid technique was used to enhance the aqueous solubility and dissolution rate to obtain faster on set of action, minimize the variability in absorption, and improve its oral bioavailability. The aim of the present study was to develop Olmesartan medoxomil liquisolid tablets using Quality by Design (QbD) approach to screen the effect of four formulation and process factors on the formulation. OLM liquisolid tablets were prepared by Liquisolid technique. Plackett-Burman (PB) design was used to screen the effect of four formulation and process factors to improve solubility and bioavailability. The liquisolid formulation were characterized by pre and post compression parameters, DSC, XRD, SEM, and in-vitro drug release. Excipients like Neusilin US2, Aerosil 200, PEG 400 and Primojel showed an influential effect on the selected...
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