Posted by admin on Jul 31, 2015 in |
Chalcones and its derivatives show various biological activities. The present study deals with the synthesis of series of 2-hydroxy-3-nitro-5-methyl–N-substituted phenyl chalcone imines from 2-hydroxy-3-nitro-5-methylphenyl chalcone and different substituted aromatic animes in ethanol in presence of 2, 3 drops of Conc. H2SO4. Structures of synthesized compounds have been established by spectral (IR, NMR, etc.) and elemental analysis. In the present communication we report the synthesis substituted chalcone imines and its antimicrobial activity against pathogenic bacteria and fungi. The sensitivity carried out by disc diffusion method displayed significant antimicrobial...
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Posted by admin on Jul 31, 2015 in |
Five medicinal plants used in the traditional medicine of India, were selected for studying their immunomodulatory potential through the activation of macrophages, individually and in synergism. The plants were Boswellia serrata Roxb., Curcuma longa L., Glycyrrhiza glabra L., Tribulusterrestris L., and Tylophora indica (Burm f.) Merr. In the present study, strong stimulation of antigen specific and nonspecific immunity was evidenced by increase in phagocytic index, percentage inhibition of yeast digestion, macrophage activation and intracellular killing capacity of all the extracts individually and of their combination in murine model. All were found to increase in a dose dependent manner. The results provide scientific basis for widespread use of these plants and their combination as tonic for immunostimulation and chronic...
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Posted by admin on Jul 31, 2015 in |
The aim of the current study is to develop a simple, specific, rapid and precise quantification technique for the estimation of tinidazole from tablet dosage form. Successful separation of the drug was carried out on a C18 column (particle size 5 µm, 250 mm length × 4 mm i.d.) using a mobile phase consisting of a 5.3 mM phosphate buffer solution and acetonitrile in the ratio of 60:40 (v/v). The detection wavelength is 318 nm. The method has been validated as per ICH (Q2) guidelines on the basis of accuracy, precession, linearity, sensitivity and robustness. The method is found to be linear with limit of detection and limit of quantitation 0.25μg/ml and 0.76μg/ml respectively. The average elution time is only 5.0 minutes with the analyte elution taking place at about 3.0 minutes making the method rapid and cost effective for routine...
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Posted by admin on Jul 31, 2015 in |
Exhaustive study of scientific literature provides the initial evidence that omega-3-fatty acids the principal component of fish oil is responsible for exerting important biological effects when administered to population at risk of coronary heart diseases and diabetes mellitus. The main reason behind the study was to evaluate the anti-atherogenic properties of marine lipids in alloxan induced diabetic mice. Furthermore the current analysis endeavours to scrutinize the Hypoglycemic effects of the natural omega-3-fatty acids. Mice were made diabetic by a single intraperitoneal (I.P.) injection of alloxan monohydrate 150 mg/kg. Treatment with appropriate dose of omega-3-fatty acid concentrate started 7days after alloxan injection. At the end of the selected period of study the blood glucose level, and lipid profile was evaluated and the data obtained was compared with normal control and positive control. All the data were subjected to due statistical evaluation. The omega-3-fatty acid treatment led to a significant dose dependent decline in the blood glucose content (P<0.05), along with crucial reduction in the lipid profile in alloxan induced diabetic...
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Posted by admin on Jul 31, 2015 in |
The present study was done to evaluate in-vitro membrane stabilizing activity with human RBC, in-vivo neuropharmacological activity including open field and swimming test, gastrointestinal motility and acute toxicity of different leaf extracts of Spondias pinnata in Swiss albino mice following oral administration. In-vivo GI motility test was done by charcoal induced anti motility test, acute toxicity study was done by investigating mortality/morbidity status of test animal and in-vitro membrane stabilizing activity was done with human RBC in both hypotonic and heat induced method. In case of in-vitro membrane stabilizing activity for hypotonic solution induced haemolysis, the ethanol extract inhibited 76.92% haemolysis of RBCs as compared to 85.42% produced by acetyl salicylic acid and during heat induced condition different organic soluble materials of S. pinnata demonstrated 76.68%, 77.19% and 74.83% inhibition of haemolysis of RBCs respectively whereas ASA inhibited 78.04%. In-vivo neuropharmacological activity showed significant (p<0.05) and (p<0.001) results when methanol 200 mg/kg, ethanol 200 mg/kg, chloroform 100 & 200 mg/kg extracts were administered to evaluate the rate of movement...
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