Posted by admin on Jul 31, 2015 in |
Larrea divaricata Cav. commonly known as “jarilla hembra” is used in folklore medicine as anti-inflammatory. There was no scientific evidence justifying the medicinal use of the aqueous extract for inflammation diseases. Nowadays, there are two principal types of anti-inflammatory drugs: Steroidal anti-inflammatory drugs (corticosteroids) and non-steroidal anti-inflammatory drugs (NSAIDs), which exert gastrointestinal ulceration and bleeding. In this work the preventive anti-inflammatory activity of L. divaricata aqueous extract (AE) in C3H/He mice was determined by carrageenan- induced inflammation and ear edema tests, also its toxicity on gastric tissues and on blood cells was studied. The chromatographic profile showed: nordihydroguaiaretic acid (NDGA) as majority compound. AE exerted anti-inflammatory action without inducing gastric or blood cell toxicities. Also, it could modulate anti-inflammatory and pro-inflammatory cytokines. NDGA was not the compound responsible of the anti-inflammatory action. This work rescues the potentiality of AE as a gastric and blood cells innocuous anti-inflammatory agent and confirms its ethno- pharmacological...
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Posted by admin on Jul 31, 2015 in |
In today’s hectic lifestyle, such dosage form as plaster, attracts more attention of scientists and gives new opportunities to use it in medicine. The purpose of our study was to investigate consumer properties of transdermal patches, hold the commodity analysis of the dosage form and determine the prospectiveness of their use in modern pharmacotherapy. Market review has been conducted. Analyzed the producing countries of transdermal patches reported on the pharmaceutical market of Ukraine. An analysis of the active ingredients used in the TTS has been carried out. Modern classifications of transdermal therapeutic systems have been given. The approaches to creation of TTS have been investigated. The most important consumer properties of TTS have been...
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Posted by admin on Jul 31, 2015 in |
Equisetum arvense, commonly known as field horsetail, is a perennial herb belonging to the genus Equisetum. Traditionally, Equisetum arvense is used as diuretic; anticoagulant, skin antiseptic, in kidney and liver related problems and gastric ulcers. E. arvense has also been suggested for the treatment of bone related disorders such as osteoporosis but the data is very scarce on its dose range and its influence on basic biochemical parameters. The present study was carried out to study its effect in female wistar rats at three levels of dose: L (30 mg/ kg of body weight), M (60 mg/ kg of body weight) and H (120 mg/ kg of body weight) for a period of 30 days. We report here complete blood count, LFT, KFT, blood glucose, total protein, and albumin and lipid profile. No toxic effects were observed in reference to clinical signs, body weight and organ weight. HBG, HCT, MCV, PLT, glucose and serum cholesterol, HDL and LDL level at H dose was found significantly different to Control group....
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Posted by admin on Jul 31, 2015 in |
Objective: The present study was aimed to investigate the phytochemical analysis and inhibitory activity of Nilgirianthus ciliatus Nees against the carbohydrate hydrolyzing enzymes. Methods: The Nilgirianthus ciliatus plant powder was extracted with ethanol by cold maceration technique. Primary and secondary metabolites present in the plant extract were identified by means of phytochemical screening or specific tests and important metabolites were quantified by means of standard procedures. The in-vitro hypoglycemic activity was subsequently assessed by enzyme inhibition assay methods. Results: The phytochemical screening showed the presence of flavanoids, phenolic compounds, tannins, steroids, glycosides and triterpenoids. Quantification results showed Nilgirianthus ciliatus has more tannin content. The in-vitro study results revealed that ethanolic extracts inhibited both α-amylase and α-glucosidase in a dose dependent manner. The extract showed higher α-glucosidase inhibitory effect (IC50=21.90 µg/ml) than α-amylase inhibitory effect (IC50=462.49µg/ml). Conclusion: The present study provides a biochemical rationale by which Nilgirianthus ciliatus Nees elicited therapeutic effect on Type 2...
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Posted by admin on Jul 31, 2015 in |
The hypolipidemic activity of Cassia tora (Chakvat, Chakunda) (Family: Caesalpiniaceae) seeds extract have been studied in alloxan-induced diabetic rats. In this model oral administration of seed extract (500 mg/kg bw.P.o.) for 15 days in diabetic-dyslipidemic rats exerted significant lipid lowering effect as assessed by the reversal of serum levels of total cholesterol, phospholipids, triglyceride, free fatty acids, protein and lipid peroxide. The decrease of lipids and apoprotein levels of Very Low Density Lipoprotein and Low Density Lipoprotein were followed by stimulation of plasma post-heparin lipolytic activity as well as lecithin cholesterol acyltransferase, hepatic superoxide dismutase, catalase, triglyceride lipase and lipoprotein lipase activities with increase in reduced glutathione. Lipid and apoprotein level of High Density Lipoprotein were also recovered partially on treatment with seeds extract. The results of the present study demonstrated antidyslipidemic and antioxidant activities in seed extract of C. tora which could be used in prevention of diabetic dyslipidemia and related complications. The hypolipidemic activity of Cassia tora seeds was compared with a standard drug glibenclamide (600 µg/...
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