Posted by admin on Jul 31, 2015 in |
Present aim to study the biochemical composition, i.e., protein, carbohydrate, lipid, ash, amino acids, fatty acids, vitamins, minerals and Carbon, Hydrogen, Nitrogen from Skeletonema costatum. The biomass of marine diatom (S.costatum) were collected from Parangipettai, Southeast cost of India. The lyophilized powder of S.costatum was used for biochemical analysis. The results of proximate composition showed that the percentage of protein was (12.12%), (carbohydrate 5.94%), (lipid 1.567%) and ash (2.96%). Totally 10 essential and non-essential amino acids were analyzed (24.49mg/g – 22.36 mg/g). The saturated mono unsaturated and poly unsaturated fatty acids was (14.86%), (4.25%) and (10.86%). The vitamins and mineral content was 384.19 mg/g – 459.64 mg/g respectively and 1.627 microgram dry powder of Skeletonema costatum contained the ratio of Carbon (15.04%), Hydrogen (2.59%) and Nitrogen (3.17%) were present. The results of this research showed that S.costatum contained valuable nutritional values and we suggest that in future research on S.costatum can be use food for...
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Posted by admin on Jul 31, 2015 in |
The aim of present work was to develop and evaluate solid lipid nanoparticles (SLNs) based gel for topical delivery of antifungal agent. Bifonazole (BFZ) is an imidazole antifungal agent having broad spectrum activity against dermatophytes, moulds, yeasts, fungi and some gram positive bacteria. BFZ SLNs systems were developed by melt emulsification followed by ultrasonication technique using Precirol ATO5 as a solid lipid and Tween 80 as a surfactant. Developed SLNs were evaluated for particle size, polydispersity index (PI), entrapment efficiency (EE) and drug release profiles. Process and formulation parameters were optimized. Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) studies were carried out on SLNs to mark the changes in the drug and lipid modifications. The BFZ SLNs based gels were prepared using Carbopol 940 as a gelling agent. The SLNs based gels were evaluated for rheological parameters, in vitro drug release and permeation studies. In vitro antifungal study suggested that the SLNs based gel was more effective in inhibiting growth of Candida albicans. Thus the study concludes that...
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Posted by admin on Jul 31, 2015 in |
Aim: To comparatively evaluate the antihypertensive efficacy and tolerability of ramipril and telmisartan in stage 1 hypertensive diabetic patients. Material and Methods: This short term, prospective, randomized, interventional, comparative clinical study was conducted amongst 53 patients of stage 1 hypertension with type 2 diabetes (27 ramipril and 26 telmisartan patients), aged 30 years and above. Ramipril was administered 5 mg/day and telmisartan 40 mg/day respectively throughout the study period of 3 months. Blood pressure was measured using mercury sphygmomanometer. Paired and unpaired student t-test was applied. Results: Mean SBP was 153.2 and 154.52 mm Hg and mean DBP 87.6 and 87.57 mm Hg in ramipril and telmisartan group respectively. During follow-up the mean SBP and DBP consistently decreased. At 3 months the mean SBP was 124.72 and 123.83 mm Hg in ramipril and telmisartan group respectively. Similarly, the mean DBP at 3 months was 78.16 and 76.7 mm Hg in ramipril and telmisartan group respectively. Although the lowering of blood pressure (both systolic and diastolic) by ramipril or telmisartan...
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Posted by admin on Jul 31, 2015 in |
Globally, more than 30 % of the onion peels arises at the retail and purchaser levels, of which the post-harvest and dealing out level wastages report for the major share. So, studies on the characterization of unutilized fractions of the onion peels specify their potential candidature for reprocessing. Maximum preservation of these phytochemicals during extraction requires optimised process parameter conditions. A microwave-assisted extraction (MAE) method was considered for extraction of total phenolics, total flavonoids and DPPH scavenging activity from onion peels. The total phenolic capacity (TPC), total flavonoids content (TFC) and antioxidant activity percentage of extracts at optimised MAE conditions. The influence of six main extraction parameters on the extraction was modelled by using a second-order regression equation. The optimal MAE conditions were 210W microwave power, 15min irradiation time and 40 mL/g solvent to material ratio. Under the MAE optimised conditions, the recovery of TPC was 94.34 mg gallic acid equivalent/g dry weight (DW), TFC was 45.61(mg/g) and free radical scavenging activity 92.25%.When bioactive phytochemicals extracted from onion skin...
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Posted by admin on Jul 31, 2015 in |
6-(2-Amino-3,5-substituted phenyl)-1,2,4-triazines were prepared by refluxing semicarbazones or thiosemicarbazones in presence of sodium hydroxide solution. 6-(3,5-Substituted-2-bromophenyl)-1,2,4-triazine derivatives and 6-(3,5-substituted-2-hydroxyphenyl)-1,2,4-triazine derivatives were prepared from 6-(2-amino-3,5-substituted phenyl)-1,2,4-triazine derivatives by sodium nitrite, hydrobromic acid, copper (I) bromide and sodium nitrite, sulfuric acid, respectively. The structures of the synthesized compounds were confirmed on the basis of their elemental analysis and spectral data (FT-IR and H1-NMR). Amongst synthesized compounds, some displayed significantly active profile against the electrically induced seizures at a dose of 30 mg/kg after 0.5 h. At the same dose level, one compound also showed activity after 4.0 h. Two compounds exhibited protection at dose level of 100 mg/kg after 0.5 h. At 4.0 h, two compounds persisted to reveal anti-MES protection at same dose, whereas two other compounds indicated to prevent seizure spread at a higher dose of 300 mg/kg after 4h. One compound displayed protection at 300 mg/kg after 0.5 h. The neurotoxicity screening data revealed that two compounds were exhibited neurotoxicity at a dose level of 300 mg/kg after...
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