Posted by admin on Aug 31, 2015 in |
The Zingiberaceae has the great importance in the plant kingdom because the members of this family give up spices, perfumes, dyes and valuable medicines. Alongside, a number of species of this family are cultivated for flowering. Mango ginger is one of the important species of this family having medicinal and biological properties such as antiageing, antibacterial, antioxidant, anti-inflammatory, antiallergic, antifungal, platelet aggregation inhibition activity and analgesic activity. In Ayurveda and Unani medicines of system, its rhizomes are useful as expectorant, appetizer, alexteric and laxtative. The rhizomes of mango ginger are also used in skin diseases, bronchitis, asthama and inflammatiom. Present examination aims to evaluate and compare antioxidant potential of different extracts of mango ginger using 1,1-diphenyl-2-picrylhydrazyl assay. In this study, methanol and ethyl acetate extracts of mango ginger rhizomes was estimated as good antioxidant activity which is may be due to phenolics, curcuminoids, essential oil, terpinoids and flavonids present in good amounts in these extracts, whereas dichloromethane and aqueous extracts has very little capability of radical scavenging...
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Posted by admin on Aug 31, 2015 in |
The present study depicts formulation and characterization of boric acid gel formulations. The formulated gels intervenes the advantages of gels along with higher and effective antimicrobial activity when compared to the formulations available in the market. The preparations were evaluated for different parameters as basic physico-chemical properties like physical appearance, texture, pH measurement, spreadability, viscosity and spectral analysis (UV-Visible and IR Spectroscopy) for its standardization. The sharp peak at 230nm was obtained in UV-Vis spectra. I.R spectra revealed that the boric acid binds extensively to the polymers. Antimicrobial activity of formulation was studied using Muller Hinton agar medium against E.coli MTCC 614 and S.aureus MTCC...
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Posted by admin on Aug 31, 2015 in |
Objective: The objective of the present investigation was to formulate and evaluate hydrodynamically balanced floating matrix controlled drug delivery system of Zolmitriptan by increasing its residence time and improves the bioavailability. Methods: Twelve different formulations of floating tablets were prepared using direct compression technique with hydrophilic polymers such as HPMC K4M, K15M, K100M and hydrophobic polymer like ethyl cellulose in different ratios. Dry powder blends of all the formulations were evaluated for precompression parameters and all the formulations were evaluated for post compression parameters after compression into tablet. Characterization of the prepared formulation was done by FTIR and DSC analysis. In-vitro dissolution studies were carried out for all the formulations and optimised formulation was analysed for kinetic as well as mechanism of drug release. Accelerated stability studies were carried out for the optimised formulation at stressed temperatures/humidity conditions i.e 40 ± 2 °C/70 ± 5% RH. Results: The evaluation results of precompression and postcompression parameters revealed that all formulations comply with the specification of official pharmacopoeias. From DSC and...
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Posted by admin on Aug 31, 2015 in |
Cotylophoron cotylophorum, the parasite of ruminants cause a disease called paramphistomosis. Paramphistomosis in domesticated ruminants cause considerable economic loss to the livestock industry in India. In the present study, the anthelmintic activity of Terminalia chebula was assessed based on its effects on the motility and acetylcholinesterase (AChE) of the digenetic trematode C. cotylophorum in vitro. The flukes were exposed to five different sub-lethal concentration of ethanol extract of Terminalia chebula (TcEE) for 2, 4 and 8h. The motility response of the drug-treated parasites was recorded with the aid of Electronic micromotility meter (EMM). Acetylcholinesterase (AChE) activity of the C. cotylophorum was assayed following standard method. The maximum inhibition of motility and AChE activity was observed at 0.5 mg/ml concentration after 8 h of exposure. Inhibition of AChE activity increased with an increase in the drug concentration and the period of exposure. AChE is an enzyme involved in neurotransmission. The ethanol extract of Terminalia chebula (TcEE) inhibits the AChE and affect the motor activity of the parasites, thus the parasite...
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Posted by admin on Aug 31, 2015 in |
Emblica officinalis and its derivative (Ascorbic acid) have profound effect on development and regeneration and are widely used in the Indian System of medicine for the treatment of different type of disease. Here, we discussed the comprehensive account of the effect of aqueous extract of the fruit of E.officinalis with special reference to cardiac tissue regeneration in frog tadpoles. E.officinalis was found to be a good model to accelerate regeneration ability of infracted cardiac cells which further give rise to intact cardiac part (intact ventricle part) in all mode of experiment employed i.e insitu (in vivo), in transplantation setup and in culture medium. The most spectacular case was rhythmic beating of implanted cardiac tissue at ectopic site of tail of E.officinalis treated tadpoles. The E.officinalis supplemented cultures were also appeared to be a suitable for investigating the changes occurred during regeneration and differentiation of cardiac...
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