Posted by admin on Jun 30, 2015 in |
An oral press-coated tablet was developed by means of direct compression to achieve the time-controlled disintegrating or rupturing function with a distinct predetermined lag time. The aim of the present study is to develop time depended drug delivery systems for Aceclofenac by using HPMC K100M and ethylcellulose (EC) as coating material. By applying 32 full factorial design, compression coated tablets of Aceclofenac containing different proportions of EC and HPMC K100M was prepared. All the formulations were evaluated for the hardness, friability, thickness, weight variation, drug content uniformity, and in-vitro drug release studies for 8 hr. Press coated tablets of Aceclofenac released different amount of the Aceclofenac, within the 8hr dissolution study, in the physiological environment of the stomach and small intestine, depending on the proportion of EC: HPMC K100M used in the formulation. The compression coated formulations have been formulated to release minimum amount of Aceclofenac within 6 hr dissolution study in the physiological environment of the stomach and small intestine. The results of the dissolution study showed that...
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Posted by admin on Jun 30, 2015 in |
Ceropegia bulbosa is a medicinal herb, this is useful in curing many disease like kidney stone and deafness. Ethno botanical study showed that the plant has good medicinal value for tribe of Rajasthan the preliminary phytochemical studies of Ceropegia attenuata tuber and leaf extracts revealed the presence of steroids, glycosides, flavonoids alkaloids, saponins, tannins, terpenoids and potassium salt. Gas chromatography mass spectroscopic investigation of methanolic extract of Ceropegia attenuata – a annual land plant is investigated by GCMS technique while the mass spectra of the compounds found in the extract are matched with the standard library of NIST. GC MS analysis revealed the presence of aromatic hydrocarbons, paraffins, fatty acids, sterol, Oleic acid, ketons and diterpenes etc. Flavone 4′-Oh,5-Oh,7-Di-O-Glucoside (12.09%) with RT=31.78 is present in maximum amount , followed by 9,12,15-Octadecatrienoic acid, methyl ester, (Z,Z,Z)- (7.92%) with RT=16.17 in the methanolic extract of leaves of C.attenuata. Steroids like Ergost-5-en-3-ol-(3.0%), Stigmast-5-Dien-3-Ol, (3.Beta.) (5.26%), Lupeol, Globulol and Phytol were also detected. Tetratetracontane (5.13%) was also present in considerable amount. The GC-MS...
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Posted by admin on Jun 30, 2015 in |
Present work has been undertaken to establish the necessary pharmacognostic standards and phytochemical evaluation of roots of Acacia catechu Willd. Various morphological parameters of fresh as well as shade dried form of the roots were studied. Microscopy shows the presence of medullary rays, starch grains, pith, phloem fibres, cork cells and xylem cells. Physico-chemical constants such as Fluorescence analysis of root powder and extracts, ash values, loss on drying, extractive value, swelling index, percentage extractive values for successive extracts, consistency and color of different extracts under ordinary and UV light were evaluated. Phytochemical screening of total ethanolic and aqueous extracts shows the presence of flavonoids, tannins, saponin glycosides, & reducing sugars. HPTLC was carried out for quantification of quercetin in ethanolic extract of the roots of A. catechu Willd. It was concluded that plant contains various phytochemicals; among these tannins and flavonoids are its main...
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Posted by admin on Jun 30, 2015 in |
Simple, linear and accurate method was developed for the quantification of Z-isomer impurity and 3, 4-dihydroxy-5-nitrobenzaldehyde intermediate in entacapone active pharmaceutical ingredient by using high performance liquid chromatography. Separation between impurities and Entacapone was achieved on Phenomenox Kinetex C18, (100 x 4.6) mm, 2.6 micron column. Mobile phase consisted of 0.1% Orthrophosphoric acid in water: Methanol in ratio 58:42:0.1 in isocratic mode for RSD of standard. Gradient method was used for sample preparation and blank with flow rate of 0.8 ml/min at 300 nm and column oven temperature at 50°C. RSD for standard preparation under system precision and percentage recovery was observed with in acceptance range. RSD for retention time was observed 0.05% which shows reproducibility during replicate injections. Limit of detection and limit of quantification was achieved at 0.1 ppm and 0.2 ppm level respectively which indicates the lowest level of detection and quantification. The linearity range was achieved from 0.2 ppm to 0.75 ppm level for entacapone, Z-isomer and intermediate. The method was applied for quantification of...
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Posted by admin on Jun 30, 2015 in |
Workers engaged in tyre retreading face the possibility of occupational exposure to benzene and toluene as these are used as solvents and glue. Exposure to these solvents in other industries has been aptly described in several reports. Considering important from public health point of view, a study on biological monitoring of benzene and toluene exposure in tyre retreaders was performed Urine samples were analyzed for the metabolites of benzene and toluene viz. phenol and hippuric acid respectively. The information like smoking, alcohol intake, age and duration of job was sought after personal interviews. Results showed, that population of smokers excreted less phenol but high hippuric acid in comparison to non smokers. Alcohol intake inhibited the metabolism of benzene and toluene. Excretion of phenol and hippuric acid was lower in alcoholics than non alcoholics. Age also affected the excretion of phenol. It was found to be lowest in the age group of 30-40 years. Excretion of phenol was lowest in workers having the work experience of 16-20 years, whereas, excretion...
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