Posted by admin on Jul 31, 2015 in |
Equisetum arvense, commonly known as field horsetail, is a perennial herb belonging to the genus Equisetum. Traditionally, Equisetum arvense is used as diuretic; anticoagulant, skin antiseptic, in kidney and liver related problems and gastric ulcers. E. arvense has also been suggested for the treatment of bone related disorders such as osteoporosis but the data is very scarce on its dose range and its influence on basic biochemical parameters. The present study was carried out to study its effect in female wistar rats at three levels of dose: L (30 mg/ kg of body weight), M (60 mg/ kg of body weight) and H (120 mg/ kg of body weight) for a period of 30 days. We report here complete blood count, LFT, KFT, blood glucose, total protein, and albumin and lipid profile. No toxic effects were observed in reference to clinical signs, body weight and organ weight. HBG, HCT, MCV, PLT, glucose and serum cholesterol, HDL and LDL level at H dose was found significantly different to Control group....
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Posted by admin on Jul 31, 2015 in |
Objective: The present study was aimed to investigate the phytochemical analysis and inhibitory activity of Nilgirianthus ciliatus Nees against the carbohydrate hydrolyzing enzymes. Methods: The Nilgirianthus ciliatus plant powder was extracted with ethanol by cold maceration technique. Primary and secondary metabolites present in the plant extract were identified by means of phytochemical screening or specific tests and important metabolites were quantified by means of standard procedures. The in-vitro hypoglycemic activity was subsequently assessed by enzyme inhibition assay methods. Results: The phytochemical screening showed the presence of flavanoids, phenolic compounds, tannins, steroids, glycosides and triterpenoids. Quantification results showed Nilgirianthus ciliatus has more tannin content. The in-vitro study results revealed that ethanolic extracts inhibited both α-amylase and α-glucosidase in a dose dependent manner. The extract showed higher α-glucosidase inhibitory effect (IC50=21.90 µg/ml) than α-amylase inhibitory effect (IC50=462.49µg/ml). Conclusion: The present study provides a biochemical rationale by which Nilgirianthus ciliatus Nees elicited therapeutic effect on Type 2...
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Posted by admin on Jul 31, 2015 in |
The hypolipidemic activity of Cassia tora (Chakvat, Chakunda) (Family: Caesalpiniaceae) seeds extract have been studied in alloxan-induced diabetic rats. In this model oral administration of seed extract (500 mg/kg bw.P.o.) for 15 days in diabetic-dyslipidemic rats exerted significant lipid lowering effect as assessed by the reversal of serum levels of total cholesterol, phospholipids, triglyceride, free fatty acids, protein and lipid peroxide. The decrease of lipids and apoprotein levels of Very Low Density Lipoprotein and Low Density Lipoprotein were followed by stimulation of plasma post-heparin lipolytic activity as well as lecithin cholesterol acyltransferase, hepatic superoxide dismutase, catalase, triglyceride lipase and lipoprotein lipase activities with increase in reduced glutathione. Lipid and apoprotein level of High Density Lipoprotein were also recovered partially on treatment with seeds extract. The results of the present study demonstrated antidyslipidemic and antioxidant activities in seed extract of C. tora which could be used in prevention of diabetic dyslipidemia and related complications. The hypolipidemic activity of Cassia tora seeds was compared with a standard drug glibenclamide (600 µg/...
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Posted by admin on Jul 31, 2015 in |
This study was undertaken to investigate the antimicrobial activities of aqueous and ethanol extracts of violet plant, Securideca longepedunculata leaves and root bark extracts against the pathogenic bacteria isolates of Salmonella typhi, Escherichia coli and Pseudomonas aeroginosa. Disc diffusion method was used for antibacterial testing and Tetracycline drug at 250 mg/ml concentration was used as positive reference standards to determine the sensitivity of the strains. The results of the antibacterial activities revealed that the highest growth inhibition of the tested bacteria was recorded as 8.00±1.00mm at 250 mg/ml, followed by 7.67±1.15mm at 250 mg/ml and the least inhibition was 3.00±2.00mm at 100 mg/ml. The minimum inhibitory concentrations for E. coli and S. typhi were 124 mg/ml and 250 mg/ml respectively. The results showed significant effect (P < 0.05) of antibacterial activity; with the constituents of S. longepedunculata leaves and root bark extracts been used as potential antimicrobial agents in the management of microbial diseases caused by pathogenic bacteria species which may in turn be an alternative to chemical antibiotics....
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Posted by admin on Jul 31, 2015 in |
The disease causing bacteria have evolved the genetic ability to transmit and acquire resistance to drugs used as therapeutic agents. The discovery of antibiotics to combat these pathogens marked a resolution in the 20th century. Unfortunately, because of the inappropriate use of antibiotics in human and veterinary medicine, certain strains of bacteria and fungi developed the ability to produce substances which block the action of antibiotics or change their target or ability to penetrate cells. One way to prevent antibiotic resistance is by exploring new bioactive compounds from traditional medicine which is not based on the existing synthetic antimicrobial agents. Phytochemicals from medicinal plants showing antimicrobial activities have the potential of filling this need, because their structures are different from those of the more studied microbial sources. The present study was conducted to evaluate the antimicrobial activity from ethanolic extract against different life threatening pathogenic microorganisms and screening for various phytochemical constituents of Lawsonia inermis Linn. According to the results obtained from current investigation, ethanolic extract of Lawsonia inermis...
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