Posted by admin on May 2, 2015 in |
A simple, rapid, precise, cost effective, stability indicating RP-HPLC method has been developed and validated for the simultaneous estimation of Doxycycline monohydrate (DOXM) and Ornidazole (ORN) in Bulk and pharmaceutical dosage form. The chromatographic separation was achieved on Hypersil BDS C18 column (250mm ×4.6mm, 5μm) using a mobile phase consisting of Buffer : Acetonitrile (55:45 v/v) pH 4 adjusted with ortho phosphoric acid at a flow rate of 1ml/min. Detection wavelength was found 260 nm. The retention time found for the drugs DOXM and ORN were 2.8 min and 4.3 min. respectively. The linearity of the method was over the range 12.5 – 75 µg/ml and 62.5– 375 µg/ml for DOXM and ORN, respectively. The validation of method was carried out utilizing ICH guidelines. The described RP-HPLC method was successfully employed for the analysis of pharmaceutical formulations containing combined dosage form. Developed HPLC method can resolve all degradant peaks of both the drugs, so this method is stability indicating in...
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Posted by admin on May 2, 2015 in |
The Present paper deals with the pharmacognostical studies on Mesua ferrea (Flowers), Carica The Present paper deals with the pharmacognostical studies on Mesua ferrea (Flowers), Carica papaya (Seeds), Asimum sanctum (Leafs) and Tribulus terrestris (Leafs). Fluorescence analysis has been performed and physicochemical characters such as ash values and extractive values have been performed. Preliminary phytochemical analysis also been performed for the various extractspapaya (Seeds), Asimum sanctum (Leafs) and Tribulus terrestris (Leafs). Fluorescence analysis has been performed and physicochemical characters such as ash values and extractive values have been performed. The Present paper deals with the pharmacognostical studies on Mesua ferrea (Flowers), Carica papaya (Seeds), Asimum sanctum (Leafs) and Tribulus terrestris (Leafs). Fluorescence analysis has been performed and physicochemical characters such as ash values and extractive values have been performed. Preliminary phytochemical analysis also been performed for the various extractsPreliminary phytochemical analysis also been performed for the various...
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Posted by admin on Apr 30, 2015 in |
Nebivolol HCl (NEB) is antihypertensive drug having β-adrenergic blocking properties. Although NEB is rapidly absorbed after oral administration, it has low bioavailability (12%), due to its low water solubility. The purpose of present work was to enhance the solubility and dissolution rate of NEB by inclusion complexation technology. Complexation is the association between two or more molecules to form a noncovalent based complex that has higher solubility than the drug itself. From solubility standpoint, complex can be put in to two categories, stacking complexes and inclusion complexes. The aim of this work was to study the influence of β-cyclodextrin (β-CD) on the biopharmaceutical properties of Nebivolol HCl. To this purpose the physicochemical characterization of NEB-β-cyclodextrin binary systems was performed both in solution and solid state. Present study includes deals with the preparation of inclusion complex of NEB ß-cyclodextrin as carrier and to evaluate NEB ß-cyclodextrin inclusion complex for various parameters viz., % practical yield, drug content, in vitro release study, drug-excipients interaction study,...
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Posted by admin on Apr 30, 2015 in |
DHFR being involved in many important cell processes, its inhibition has long been an attractive goal for the development of chemotherapeutic agents. In present work, efforts have been made to model the DHFR inhibitory activity of a series of 4,6-diamino-2,2-dimethyl-1,2-dihydro-1,3,5-triazine derivatives to identify the structural requirements for the binding affinity between the receptor and Triazine derivatives. Quantum chemical properties like electron density on specific atoms, net charge on specific atom, binding energy, HOMO, LUMO etc. were used for various structural activity relationship investigations for a series of derivatives of Baker’s triazine for proposals of new compounds which might be useful for the development of effective drugs. The parameters were calculated by optimizing the molecule using MM+ force field. To develop the model with significant statistics and predicting ability, quantum chemical computations were made by using step-wise regression analysis and validated by various cross-validation parameters. The results were discussed on the basis of maximum R2 value which indicates that penta-parametric model is the most significant model for the...
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Posted by admin on Apr 30, 2015 in |
The prime aim of this research paper is to find out the various kinds of intermolecular interactions in the alcoholic tramadol below the room temperature. Study of molecular interaction in the mixture of alcohols namely ethanol,1-propanol,1-butanol with tramadol drug at T = 278.15 K have been examined under the ultrasonic technique at 2MHz. Ultrasonic data of drug solutions has been evaluated at various desired acoustical parameters e.g. Free length, adiabatic compressibility, relative association, molar sound velocity, adiabatic compressibility, internal pressure etc. In this research, investigation is carrying out the various types of possible molecular interaction in the solution. These parameters have been thoroughly analyzed and eventually interpreted at the possible molecular interactions such as structure making and structure breaking effect and also solute-solvent, ionic interaction, H-bonding effect in the alcoholic tramadol drug solution. It can be concluded that there is associative behavior in the alcoholic tramadol solution at desired...
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