Posted by admin on May 30, 2015 in |
Molecular effects of androgens on cardiovascular system are variable in nature and are concentration dependent. In spite of the evidences favoring possible involvement of reduced endogenous androgens in the pathogenesis of atherosclerotic vascular disease, there is no certain role of exogenous testosterone supplementation in normal or hypogonadal males to slow down the progression of atherosclerosis. Replacement of testosterone in certain trials resulted in significant reduction in the levels of inflammatory mediators which are considered as important biomarkers in atherosclerosis. Present study aimed mainly to configure firstly the onset of inflammatory markers, dyslipidemia, insulin resistance, endothelial dysfunction (cardiovascular risk factors) as developed in castrated male rats. Secondly the role of testosterone replacement using various dose levels, expressed as low, medium and high respectively. Certain Biomarkers were selected for evaluation and are mainly serum glucose, insulin, lipogram pattern, CRP, IL-6, Endothelin-1 and plasma fibrinogen. Castration of rats and almost testosterone depletion has led to disturbance in glucose metabolism, lipogram pattern, increased inflammatory markers and plasma fibrinogen. Testosterone administration induced evident improvement,...
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Posted by admin on May 30, 2015 in |
The present investigation deals with preliminary phytochemical analysis and in vitro antibacterial potentials of different solvent extracts of Gymnema sylvestre were demonstrated. The phytochemical tests of the extracts have revealed the presence of alkaloids, flavonoids, phenols, tannins, terpenoids carbohydrate, tannin, and saponin. Five gram-positive (Bacillus cereus, Bacillus subtilis, Streptococcus cremoris, Streptococcus fecalis, Staphylococcus aureus) and five gram-negative (Klebsiella pneumoniae, Proteus vulgaris, Salmonella paratyphi, Shigella boydi, Shigella dysentriae) bacterial strains were tested. The ethanol extracts have been showed encouraging results. The maximum inhibition were recorded 42.3mm in Bacillus cereus at 250µl concentration followed by E. coli (38.4mm), Streptococcus fecalis (37.2mm), Klebsiella pneumonia (35.6mm), S. aureus (33.3mm), P. aeruginosa (30.5mm), S. cremoris (28.1mm) Proteus vulgaris (26.9mm) B. subtilis (23.5mm) and least inhibition was observed in S. typhi (21.7mm). Moderate activity was observed in chloroform extract. Minimum activity was observed in hexane at different concentration tested. Compared to synthetic antibiotic Ampicillin (50mg), solvent extracts showed significant antibacterial activity. The present findings support to the traditional knowledge of the medicinal plants to the...
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Posted by admin on May 30, 2015 in |
The Turmeric (Curcuma Longa.L) plant, a perennial herb belonging to the ginger family is cultivated extensively in South East Asian countries. The polyphenols Curcumin, De methoxy curcumin and Bisdemethoxy curcumin collectively known as curcuminoids ,which aid in the treatment of degenerative diseases like cancer, alzheimer’s, cardio vascular diseases, arthritis, diabetes and immune deficiencies .Curcuminoids are generally present in the rhizome in the ratio Curcumin : DMC : BDMC 55-60% : 19 -21 % :20–24% respectively. When the rhizhome is extracted and the curcuminoids isolated from the extract,there is a composition change from what is naturally found in the rhizhome. The present study gives a comparative data of bio-absorption of two turmeric formulations containing curcuminoids in a varied composition compared to regular turmeric extract. Regular Turmeric extract with 96.5% curcuminoids and two different formulation containing 7.8% curcuminoids and 51% curcuminoids were orally administered to adult albino rats which were divided into 10 groups based on different doses of test item (50 mg/kg, 150mg/kg, 300mg/kg).The absorption of curcuminoids was studied by...
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Posted by admin on May 30, 2015 in |
Nicotine and atorvastatin have indirect effects on reproductive function. So this study focused on changes in testosterone biosynthesis in rats co administered nicotine and atorvastatin. Rats were divided into 4 groups.(1) Control, (2) Atorvastatin (10 mg/Kg b.wt), (3) Nicotine (0.6 mg/Kg b.wt)and (4) Atorvastatin (10 mg/Kg b.wt) + nicotine (0.6 mg/Kg b.wt). After sixty days of treatment testicular cholesterol level, serum testosterone level, activity of HMG CoA reductase in the liver, activities and expressions of testicular steroidogenic enzymes; 3β-hydroxysteroid dehydrogenase (3β-HSD) and 17β-hydroxysteroid dehydrogenase (17β-HSD)and peroxidation products were assayed. Nicotine administration caused hypercholesterolemia, decreased expression of steroidogenic enzymes and testosterone levels. Administration of atorvastatin reduced cholesterol levels, decreased the expression and activity of steroidogenic enzymes and testosterone levels. Co-administration of nicotine and atorvastatin enhanced the testosterone level in comparison with nicotine administration. Enhanced biosynthesis of testosterone in coadministered group may be due to increased activities and expressions of 3β-HSD and 17β-HSD and enhanced expression of StAR protein indicating enhanced transportation of cholesterol. Reduction in oxidative stress was also a...
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Posted by admin on May 30, 2015 in |
During the recent times, the whole world is conscious about the health hazards and toxicity associated with indiscriminate use of synthetic drugs. There is extensive surge of drugs which are safer and having fewer side effects. So there is a growing interest in natural remedies for the management of different ailments. Ayurveda describes different remedies prepared by using maximum percentage of therapeutically potent herbal ingredients. Dandruff is a common scalp disorder that even affects almost half of the population at the pre-pubertal age and of any gender or ethnicity. Description of lepa (preparation used for external application) is available in classical texts in the name of Amrabeejadilepa. Ingredients used for the preparation of this lepa are, Amarbeejamajja (seed kernel of Mangifera indica) and Haritakiphala majja (fruit pulp of Terminaliachubela). Lepa is applied along with milk over scalp 2 in severe dandruff. This promulgation has good anti-microbial, anti-oxidant and anti-inflammatory activity. The present work deals with the development of the amrabeejadi Anti-dandruff cream from amrabeejadilepa (Ayurvedic preparation). Amrabeejadi antidandruff cream...
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