Posted by admin on Mar 30, 2015 in |
Diabetes mellitus (DM) is a complex metabolic disease characterized by chronic hyperglycaemia commonly associated with oxidative stress. The current study aims at assessing the antioxidant and antidiabetic potential of various concentrations of hydroalcoholic extract of Centratherum anthelminticum. The in vitro antioxidant activity was assessed using 1,1-Diphenyl-2-picrilhydrazyl (DPPH), nitric oxide, hydroxyl ion and hydrogen peroxide for free radical scavenging properties of the extracts, and determining their phenol and flavanoid contents. The antidiabetic activity was tested in rats following streptozotocin diabetes induction. The in vitro antioxidant activity using DPPH, nitric oxide radical, hydroxyl radical and H2O2 radical showed IC50 value 68.27 ± 0.34, 82.05 ± 0.46, 113.49 ± 0.86 and 94.71 ± 0.78 μg/ml respectively. The hydroethanol extract of plant seed (250, 500 and 750 mg/Kg) exhibited significant antidiabetic activities with 40.46%, 56.37% and 52.15% glycaemia reduction, respectively. These findings suggest that C. anthelminticum seeds possess both antidiabetic and antioxidant properties, and therefore could be used as starting point for the development of herbal medicines and/or source of new drug molecules...
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Posted by admin on Mar 30, 2015 in |
The objective of this study was to evaluate the possible antimicrobial properties of water, methanol, chloroform and Petroleum ether extracts of leaves of different Indian medicinal plants including Mangifera indica Linn, Ixora parviflora Vahl, Psydium guajava Linn, Calotropis procera Ait. The extracts were investigated individually for in vitro antibacterial activity by cup plate (well diffusion) method against nine pathogenic bacteria cultures. Of all the plants investigated for antimicrobial potential, the leaf extracts of Psydium guajava showed high antimicrobial activity against the tested microorganisms. Methanolic leaf extract of Psydium guajava was found to exhibit highest antimicrobial activity. Water leaf extracts of Mangifera. Indica and Ixora parviflora did not show antimicrobial activity. Phenolic content of Psydium guajava could contribute towards its antibacterial activity. The antibacterial activities of the investigated plants could make it useful in microbial...
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Posted by admin on Mar 30, 2015 in |
Nilavembu Kudineer, a Siddha Polyherbal formulation, is a decoction concentrate widely used in Siddha Medicine to combat major type(s) of fevers including viral origin such as Dengue. Methodology: Study type: Prospective case-control with Retrospective data collection. Study Setting: National Institute of Siddha – it is a central Government Siddha Hospital, located at Chennai, Tamil Nadu and considered as an apex Institute for Siddha Medicine in India. Study Subjects: Patients reported at OPD. Inclusion Criteria: Fever patients with clinical symptoms of viral fever and / or Thrombocytopenia as “Cases”. Patients without symptoms of viral fever but age-sex matched with case-subject as “Controls”. A person who has consumed minimum 5 days of Nilavembu Kudineer was considered as Nilavembu consumed person. Exclusion Criteria: Malarial fever, Enteric fever, Filarial fever, Sepsis, Leptospirosis etc. Sample size: 176 cases and 352 controls. Study period: 4 months. Statistical tools: Odds Ratio, Conditional Logistic regression. Results: The odds of Nilavembu Kudineer consumed persons for developing viral related fever was 0.24 (CI: 0.13 to 0.45) which was statistically...
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Posted by admin on Mar 30, 2015 in |
The present study is an attempt to minimize the dosing frequency and to target the Metoprolol succinate to the colon. Drug loaded pellets are coated with pH independent Eudragit RS100 and further coated with pH dependent Eudragit S100 in R and D pan coater. 3 2 full factorial design is applied to study the effect of extent of Eudragit S100 coating %w/w (X1) and extent of Eudragit RS100 coating %w/w (X2) as independent variables on the dependent variables (responses) are Y1=Q5 (% released after lag time of 5h) and Y2=Q90 (90% of drug release within 12h). The formulation were further characterized by in vitro dissolution study, drug release kinetics and micromeritic properties. 32 factorial design reveals that coating level of both the coats play a significant role in drug release property of which coating level of Eudragit RS 100 was more significant after the tablet reaches colon. Design expert software gives D5 as optimized batch having 20% w/w Eudragit RS 100 and 30% w/w with S100 as the drug...
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Posted by admin on Mar 30, 2015 in |
Black pepper (Piper nigrum) is a spice vine crop and which was used as a food preservative and as an essential component in traditional medicines. Moreover it is used also as a spice for curry cooking. The fruits and leaves may be both contains the medicinal activities. First time our concentration on to the fruits only. The fruits were collected and normally dried in the sunlight. The dried fruit was then converted into powder material. Then the powder of black pepper was extracted with ethanol in a soxhlet’s apparatus. The concentrated filtrate was isolated by column chromatography using solvent system-benzene: ethyl acetate (3:1). Again, recrystallization was performed by benzene with a minimum volume of chloroform to give pale yellow crystals of MP. 128-129oC (Reported 130oC). The IR, 1HNR and mass spectra of the pure crystalline compound (A2) were recorded. The mass spectra shows molecular ion M+∙ 284.5 which indicates that the molecular weight of the compound A2 is equal to that of piperinemolecular weight...
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