Posted by admin on May 30, 2015 in |
The leaves and fruits of Smilax perfoliata are traditionally used for treatment of various ailments such as rheumatism, lumbago, nourishing the functions of spleen, stomach, muscle and bone. The intent of the present study was to evaluate the antioxidant and anti-ulcer activity of ethanolic leaves and fruits extract of Smilax perfoliata Linn in albino rats. Gastric ulcers were induced by employing pylorus ligation method of induction. The anti-ulcer activity was analyzed by estimation of free acidity and the total acidity. The antioxidant potential was analyzed by method of DPPH free radical scavenging activity. The results obtained showed that the leaves and fruits of Smilax perfoliata possess antioxidant potential and are capable in the ministration of gastric...
Read More
Posted by admin on May 30, 2015 in |
In the present study, the hydro-alcoholic and hexane extracts of the plant, Valeriana jatamansi (Family: Valerianaceae) were screened for antimicrobial activity against pathogenic and drug resistant strains. The non polar extracts did not showed any activity against any of the pathogenic strains. Amongst these extracts the hydro-alcoholic extracts of the plant, Valeriana jatamansi, showed potent antimicrobial activity against almost all the pathogens studied. These extracts also showed potent antibacterial activity against multidrug resistant Staphylococcus aureus and Pseudomonas aeruginosa in the ranges from 0.3 mg/ml to 0.7 mg/ml. The potent hydro-alcoholic extract was further subjected for isolation and characterization of potent antimicrobial compound via chromatographic and spectroscopic techniques. The pure compound isolated, Valerenic acid was obtained as colorless liquid with a penetrating aroma; slightly soluble in water, soluble in alcohol, and ether. It melts at -34 0C and boils at 186 0C. The compound showed Rf value 0.37 similar to that of the standard compound, Valerenic acid as detected by TLC. The retention time of the pure compound purified was...
Read More
Posted by admin on May 2, 2015 in |
A simple, rapid, precise, cost effective, stability indicating RP-HPLC method has been developed and validated for the simultaneous estimation of Doxycycline monohydrate (DOXM) and Ornidazole (ORN) in Bulk and pharmaceutical dosage form. The chromatographic separation was achieved on Hypersil BDS C18 column (250mm ×4.6mm, 5μm) using a mobile phase consisting of Buffer : Acetonitrile (55:45 v/v) pH 4 adjusted with ortho phosphoric acid at a flow rate of 1ml/min. Detection wavelength was found 260 nm. The retention time found for the drugs DOXM and ORN were 2.8 min and 4.3 min. respectively. The linearity of the method was over the range 12.5 – 75 µg/ml and 62.5– 375 µg/ml for DOXM and ORN, respectively. The validation of method was carried out utilizing ICH guidelines. The described RP-HPLC method was successfully employed for the analysis of pharmaceutical formulations containing combined dosage form. Developed HPLC method can resolve all degradant peaks of both the drugs, so this method is stability indicating in...
Read More
Posted by admin on May 2, 2015 in |
The Present paper deals with the pharmacognostical studies on Mesua ferrea (Flowers), Carica The Present paper deals with the pharmacognostical studies on Mesua ferrea (Flowers), Carica papaya (Seeds), Asimum sanctum (Leafs) and Tribulus terrestris (Leafs). Fluorescence analysis has been performed and physicochemical characters such as ash values and extractive values have been performed. Preliminary phytochemical analysis also been performed for the various extractspapaya (Seeds), Asimum sanctum (Leafs) and Tribulus terrestris (Leafs). Fluorescence analysis has been performed and physicochemical characters such as ash values and extractive values have been performed. The Present paper deals with the pharmacognostical studies on Mesua ferrea (Flowers), Carica papaya (Seeds), Asimum sanctum (Leafs) and Tribulus terrestris (Leafs). Fluorescence analysis has been performed and physicochemical characters such as ash values and extractive values have been performed. Preliminary phytochemical analysis also been performed for the various extractsPreliminary phytochemical analysis also been performed for the various...
Read More
Posted by admin on Apr 30, 2015 in |
Nebivolol HCl (NEB) is antihypertensive drug having β-adrenergic blocking properties. Although NEB is rapidly absorbed after oral administration, it has low bioavailability (12%), due to its low water solubility. The purpose of present work was to enhance the solubility and dissolution rate of NEB by inclusion complexation technology. Complexation is the association between two or more molecules to form a noncovalent based complex that has higher solubility than the drug itself. From solubility standpoint, complex can be put in to two categories, stacking complexes and inclusion complexes. The aim of this work was to study the influence of β-cyclodextrin (β-CD) on the biopharmaceutical properties of Nebivolol HCl. To this purpose the physicochemical characterization of NEB-β-cyclodextrin binary systems was performed both in solution and solid state. Present study includes deals with the preparation of inclusion complex of NEB ß-cyclodextrin as carrier and to evaluate NEB ß-cyclodextrin inclusion complex for various parameters viz., % practical yield, drug content, in vitro release study, drug-excipients interaction study,...
Read More
