Posted by admin on Jun 30, 2015 in |
Vinca alkaloids are a subset of drugs obtained from the Madagascar periwinkle plant, Catharanthus roseus and have hypoglycemic as well as cytotoxic effects. They are used for treating diabetes, high blood pressure and have been used as disinfectants. The vinca alkaloids are important for being cancer fighters, as they work by inhibiting the ability of cancer cells to divide. Upon acting on tubulin, they prevent the formation of microtubules, an essential component for cellular division. . There are four major vinca alkaloids in clinical use: Vinblastine (VBL), vinorelbine (VRL), vincristine (VCR) and vindesine (VDS). Vinblastine is most often used to treat breast cancer and germ cell tumors. Vinorelbine has exhibited significant antitumor activity in patients with breast cancer and anti proliferation effects on osteosarcoma (bone tumor cells). Vincristine is FDA approved to treat Wilm’s tumor, acute leukaemia and other lymphomas. Vindesine is used in the treatment of melanoma, lung cancers and uterine cancers. Vinflunine is used for the treatment of second-line transitional cell carcinoma of the urothelium. In the...
Read More
Posted by admin on Jun 30, 2015 in |
Herein method for the synthesis of substituted 1,2-benzoxazolone (8a-f) and 3-chloro-1,2-benzoxazole (9a-f) derivatives has been described. A new scheme has been adapted for the construction of 1,2-benzoxazole ring from salicylic acid and its derivatives which leads to the formation of series of 5,6 and 7 substituted title compounds. Synthesized compounds were characterized by IR, 1H-NMR and Mass spectral analysis. Spectral data confirmed the compounds formation. Final compounds (8a-f) and (9a-f) were screened for their in-vivo analgesic activity by acetic acid induced writhing method in rats and anti-inflammatory activity by carrageenan-induced paw edema model. Among the compounds screened compound 8a and compound 9c showed good analgesic activity of about 45% (writhing mean 8.9) and 54% (writhing mean 7.5) inhibition respectively at 5 mg/Kg po dosage. Compounds 8b and 9b (both having inhibition edema of 66.1%) showed significant anti-inflammatory activity. Other derivatives exhibit moderate to good analgesic and anti-inflammatory...
Read More
Posted by admin on Jun 30, 2015 in |
We intended desired ointment developed for bacterial infection. So Levofloxacin is a fluoroquinolones of antibacterial drug effective in the treatment of bacterial conjunctivitis, sinus, kidney, bladder or prostate Here the main objective of the present work is besides delivering drugs to the body, A drug delivery system to improve patient compliance and dispersible are no exception. So we have selected the topical drug delivery system by using a formulation of ointment. The Levofloxacin ointment is prepared by the two ointment bases, namely Oleaginous and Emulsion bases. To assess the efficiency of Levofloxacin ointment by physical appearance, viscosity, PH and spreadibility, Rheological properties and micro biological studies. The Oleaginous base prepared by using white bees wax and petrolatum and emulsion base having the methyl paraben, propyl paraben, sodium lauryl sulfate, propylene glycol, stearyl alcohol white, white petrolatum, purified water. The % of drug content of Levofloxacin was found to be 99.53. The PH was found to be 5.1 % colour was found to be formulation A (Oleaginous) is light yellowish...
Read More
Posted by admin on Jun 30, 2015 in |
There are millions of micro-organisms around us, amongst 20-25% are non pathogenic. Pathogenic microbes present in the environment around us are responsible for various health related problems. Reducing microbial load to non-pathogenic levels may be the purpose of traditional fumigation techniques like Dhoopana, Homa, and Havana etc. This is also evident from Ayurvedic literature wherein fumigation is indicated for sterilisation of operation theatres as well as labour theatres and also in wound management. Taking all these into consideration, in present study an attempt is made to estimate anti microbial effect of Dhoopana of an indigenous fumigation formulation ‘DHUP’. Two rooms of same size which are in routine usage in almost similar fashion were selected for the study. One room served as control without any intervention. In the second room Dhoopana was performed once daily for two days. In both the rooms agar gel plates were exposed at selected places and efficacy of DHUP Dhoopana was noted at selected intervals. The microbial load was estimated and subjected to statistical analysis....
Read More
Posted by admin on Jun 30, 2015 in |
A simple, sensitive, precise, accurate and cost effective reverse phase high performance liquid chromatographic method for the simultaneous estimation of bupropion HCl and naltrexone HCl from a single formulation was developed and validated in accordance to ICH guidelines. The two drugs were eluted under isocratic mode using a 250 x 4.6 mm i.d, 0.45 µm Phenomenex Chromosil C18 column. The mobile phase was composed of a mixture of methanol, acetonitrile and water in the ratio of 60:20:20 v/v (pH adjusted to 4.8) at a flow rate of 1.0mL/min. The limit of detection and limit of quantification were found to be 0.5μg/mL and 1.7μg/mL, for both the drugs. The label claim of the combined dosage form was in good agreement with the experimental assay amounts; 99.5% and 99.7% for bupropion HCl and naltrexone HCl, respectively. This method can be successfully applied for the simultaneous estimation of bupropion HCl and naltrexone HCl combination for routine quality control...
Read More
