Posted by admin on Mar 30, 2015 in |
The aim of the present study was to evaluate the anxiolytic effects and motor activity of ethanolic and aqueous extracts of leaves of Dendrophthoe falcata (DF) in mice. Swiss albino mice were treated orally with ethanolic and aqueous extracts of DF leaves (250 mg/kg and 500 mg/kg) and distilled water along with alprazolam (1 mg/kg) intraperitoneally for seven days and then exposed to Elevated Plus Maze (EPM) and Light Dark Box (LDB). The effects of the plant extracts on motor coordination were evaluated by Rota rod test. We further investigated the mechanism of action underlying the anxiolytic-like effect of the extracts by pre-treating animals with antagonist of benzodiazepine (flumazenil, 3mg/kg) prior to evaluation using EPM and LDB. Mice treated with ethanol DF extract (250 mg/kg) showed significant increase in; percentage of open arm entries, time spent in open arms of EPM and decrease in motor coordination in Rotarod test. Furthermore, the ethanol DF extracts (250 mg/kg and 500 mg/kg) significantly increased the percentage of time spent and number of...
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Posted by admin on Mar 30, 2015 in |
In diabetes, infertility is a common complication in diabetic men and experimental animals. The aim of this study was to investigate the protective effect of methanolic leaf extract of Clerodendrum infortunatum (MECI) on programmed cell death in the testicular damage resulting from streptozotocin (STZ) induced diabetes in rats. Diabetes was induced by a single intraperitoneal injection of STZ (50 mg/kg), and the rats were treated with MECI (250 mg/kg and 500 mg/kg) administered once a day orally for 28 days, starting 3 days after the STZ injection. Blood glucose were checked in diabetic induced animals. At the end of the study, all animals were sacrificed. Testis tissues were collected for the assessment of sperm parameters, and for biochemical and histopathological analysis. The MECI-treated rats in the diabetic group showed an improved blood sugar, histological appearance, sperm parameters and program cell death. These results suggest that methanolic leaf extract of Clerodendrum infortunatum is a potentially beneficial in reducing testicular damage in diabetic...
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Posted by admin on Mar 30, 2015 in |
The present study was designed to investigate the effect of two different types of plasticizers, i.e., Triethyl citrate (TEC) and Acetyl tri butyl citrate on the in vitro release kinetics of Budesonide from sustained-release pellets during initial and stability conditions. Ethyl cellulose aqueous dispersion (Aqua coat ECD 30) is used as the release-retarding polymer. Both plasticizers were used at 10 % to 30% (w/w) of Aqua coat ECD 30. Sugar spheres #16/20 were used as core pellets. Dissolution study was performed by using USP apparatus II with sinker in 0.1 N HCl followed by 7.5 pH phosphate buffer. Trails planned with water insoluble plasticizer like acetyl tri butyl citrate showed comparative dissolution profile with innovator during initial condition but during accelerated stability conditions like 40ºC 75% RH for 6M dissolution profile was found to be on lower side when compared with innovator. Hence trails were planned with water soluble plasticizer like tri ethyl citrate showed comparable dissolution profile with innovator during initial and stability conditions. Different trails were planned...
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Posted by admin on Mar 30, 2015 in |
Acetone extracts of the three medicinal plants Sida cardifolia, Phyllanthus amarus and Adathoda vasica were assessed for phytochemical components qualitatively and quantitatively and antioxidant activity. The results revealed that all the three contained alkaloids, carbohydrates, flavonoids, tannins, anthocyanins, steroids and phenols. Saponins were absent in all the three extracts. Sida cardifolia with 1.53mg and 7.09mg GA equivalent/g of extract powder showed maximum amount of Phenolics and flavonoids.The total sugars and proanthocyanidins was maximum in Phyllanthus amarus with 8.45ug glucose equivalent/g of extract powder and 10.84mg GA equivalent/g of extract powder. Tannin content was found to be high in Adathoda vasica with 11.07mg GA equivalent/g of extract powder. Sida cardifolia acetone leaf extract showed the highest reducing power activity, Free radical scavenging potential and inhibition of lipid...
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Posted by admin on Mar 30, 2015 in |
Aim of this study was to compare bupivacaine heavy ( 0.5% ) 3ml with isobaric ropivacaine (0.75% ) 3ml, intrathecally in patients posted for lower abdominal and lower limb surgery for sensory and motor effects and hemodynamic stability. 100 patients aged 12 years or older (ASA grade I, II, III) scheduled for various lower abdominal and lower limb surgeries were randomly distributed in two groups. In group B (n= 50) 15 mg of hyperbaric bupivacaine (0.5%, 3ml) and in group R (n=50) 21.5 mg of isobaric ropivacaine (0.75%, 3ml) was given intrathecally. All observations were recorded and analyzed statistically by using unpaired t-test and P- value < 0.05 was considered significant. No statistically significant difference in onset of sensory blockade up to T10, onset of motor block (grade “I”), mean duration of analgesia and side effects was observed between both groups. Statistically significant difference in onset of motor blockade at grade “III” was observed between group B and R. Statistically significant mean duration of sensory and motor blockage was...
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