Posted by admin on Mar 30, 2015 in |
Medicinal plants have been used since prehistoric period for the cure of various diseases. Hence the herbal medicines occupy distinct position right from the primitive period to present day. Calotropis procera, a wild growing plant of family Asclepiadaceae, is well known for its medicinal properties. Different parts of this plant have been reported to exhibit anti-inflammatory, analgesic, and antioxidant properties. Calotropis gigantea found in dry waste places, therapeutically used as Anti-cancer, intermittent fever, paralysed part of body painful joints, swelling, heals wounds (leaves). The present study was undertaken to analyse the various active phytochemical constituents and to study detailed anatomical features of two species of Calotropis (family: Asclepediaceae) i.e., C.procera, C.gigantea. A qualitative analysis was performed for detection of alkaloids, glycosides, terpenoids, steroids and flavanoids. HPLC (High Performance Liquid Chromatography) was used in identifying the qualitative and quantitative analysis of active principle index of two species of Calotropis present in the area of present study. Anatomical features of various plant parts were found useful for correct easy identification of...
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Posted by admin on Mar 30, 2015 in |
In eukaryotes, DNA is packaged into chromatin structures, whose basic unit is the nucleosome. A principle component of chromatin that plays an important role in the regulation of DNA is the modification of histones. Since histones are post-translationally modified, there inludes a large number of different histone post-translational modifications. These histone modifications create a repressive environment for gene expression, which in case of histone acetylation, are controlled by competing activities of two families of enzymes, histone acetyltransferases (HAT’s) and histone deacetylases (HDACs). HDAC11 is a class IV protein of the HDAC family. The present aim of this study is to develop a model of HDAC11 by using bioinformatics applications. The design of the model is based on thorough evaluation of the HDAC-11 query sequence, Q96DB2, which was retrieved from UniProtKB. The physiochemical and primary analysis were computed using ExPASy Protparam tool. Functional characterization was computed using RaptorX, HMMTOP and Softberry Server’s CYS_REC tool (Cysteine Recognition Server) which predicted the secondary structure composition, presence of transmembrane proteins and the presence...
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Posted by admin on Mar 30, 2015 in |
The objective of the present study was to investigate the immunomodulatory activity of the roots of Ichnocarpus frutescents R.Br. In the present study Pet. Ether, Chloroform and Methanolic fractions of the ethanolic extract of the roots of Ichnocarpus frutescens, in the doses of 10mg/kg and 30mg/kg, were administered orally to evaluate the immunomodulatory activity. The Methanolic fraction in the dose of 30mg/kg showed most significant effect when compared with control group, in the E.Coli induced abdominal sepsis and Carbon Clearence Test as models for non-specific immune response. In the models of the Specific immune response, in cell mediated immune response to SRBC – delayed type of hypersensitivity (DTH) the Methanolic fraction in the dose 30 mg/kg showed most significant effect on decrease in footpad edema after treatment when compared with control group. Humoral immune response was assessed by Sheep erythrocyte agglutination test, in which the Methanolic fraction of IF 30mg/kg showed most significant (p<0.05) increase in antibody titer after treatment when compared with control group. The present investigation reveals...
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Posted by admin on Mar 30, 2015 in |
Present study was designed to evaluate the antioxidant and hematoprotective activity of methanolic extract of saraca indica bark. Antioxidants and hematoprotective effect of saraca indica bark may be due to its polyphenolic compounds. Polyphenols act as reducing agents via scavenging of free radicals and chelation of transition metals. The hematoprotective activity of Saraca indica was studied in Phenylhydrazine induced anemic rats. Anemia was induced by an oral administration of Phenylhydrazine for a period of 7 days. Hgb concentration, RBC count, PCV, MCH, MCHC were analyzed as indices of anemia. Phenylhydrazine significantly decrease the Hgb, RBC and increased MCV and WBC. The Saraca indica was administered at the dose levels of 200mg/kg, 400mg/kg orally to the animals for 14 days. After 14 days of treatment with Saraca indica at the dose level of 400 mg/kg significantly reverse the above parameters and turn towards the normal value. These results support the traditional use of Saraca indica in the treatment of...
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Posted by admin on Mar 30, 2015 in |
The present investigation was carried out in five villages of the marginalized hill area block of Dewal in Chamoli district, regarding the uses of mild and native ethno-medicinal plants, by locals in their traditional health care system. The people residing in this area have been in isolation for centuries and possess good knowledge of phytotherapy. A total of 51 species of medicinal plants (both wild and cultivated) belonging to 30 families and 45 genera are being used in their folk system of treatment (locally known as ‘Gharelu Upchar’). These plants are used in crude form to treat various ailments like, cough and cold, stomach problems, skin diseases, dysentery, boils and pimples, anaemia asthma, cuts and wounds, various fevers, bone fractures, kidney/ gall stone problems and other such indispositions (Table 1.1 and 1.2). The main purpose of this study was to document the indigenous knowledge of Vaidyas and other knowledgeable persons of the area about the use of local flora, as household remedies for treating different...
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