Posted by admin on Mar 30, 2015 in |
Aim and Objectives: To study the analgesic activity of telmisartan in graded doses, in tail flick method and acetic acid induced writhing method in rats and mice respectively. Materials and Methods: Analgesic activity of telmisartan was evaluated in graded doses tail flick model (for central action) and acetic acid induced writhing model (for peripheral action) of analgesia. Aspirin & tramadol were used as standard drugs. Results were analyzed by one way ANOVA followed by Bonferroni’s post hoc test. Results: In tail flick method telmisartan showed dose dependent analgesic activity. The tail flick latency time increased from 0 to 60 min. The analgesic activity of telmisartan at dose of 1.5mg/kg was not statistically significant, however it was statistically significant at dose 3mg/kg and 4.5 mg/kg. At the dose of 3mg/kg; telmisartan showed highly significant activity p<0.01 at 30, 60 as well as 90 min with maximum effect at 90min, where as the most significant effect p<0.001 was observed at the dose of 4.5mg/kg at 60 and 90min. In acetic acid...
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Posted by admin on Mar 30, 2015 in |
Rivaroxaban is a direct inhibitor for Factor Xa that used orally for prevention and treatment of thromboembolic disorders through inhibition of thrombin synthesis. In this study we hypothesis that rivaroxaban pretreatment might play a role in reducing the complications of myocardial ischemic reperfusion injury (IRI) in a rat model of obesity. R- hirudin (a commercially available anticoagulant drug used previously in attenuating the harmful effects of myocardial IRI) was used as a positive control in this study. To achieve this hypothesis, male Wistar albino rats were randomly assigned into 4 groups (n = 6 per group): control subjected to IRI, obese subjected to IRI, obese rats pretreated with r- hirudin (1.8 mg/kg body weight) then subjected to IRI, obese pretreated with Rivaroxaban (3 mg/kg body weight/day) then subjected to IRI. Obesity was induced by feeding rats high fat diet. Myocardial ischemia was induced by left anterior descending artery ligation (LAD). The obese rats subjected to IRI showed significant increases in the inflammatory markers (myocardial angiotensin II, tumor necrosis factor...
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Posted by admin on Mar 30, 2015 in |
Alstonia venenata a member of the family Apocynaceae, finds a prominent place in Ayurveda system of medicine and also among different tribal groups in India for a variety of diseases such as fever, epilepsy, malaria and a variety of skin diseases. A.venenata was studied to investigate the bioactive properties. Various plant parts like leaves, stem-bark, root-bark, flowers and fruits were extracted with a variety of solvents ranging from non-polar to polar and screened for bioactivity. Butanol and methanol extracts of all the parts alone were selected for antifungal testing. The tested organisms included human pathogens and laboratory contaminants/opportunistic fungi .They were Pencillium marniffi, Cyrptococcus sp., Candida sp., Epidermophyton sp., Microsporum sp., Fusarium sp., Pencillium sp., Aspergillus flavus, Aspergillus niger and Rhizopus sp. Different concentrations of the extracts dissolved in DMSO were incorporated in Sabouraud Dextrose Agar (SDA) and a final concentration of 50mg, 100mg and 125mg per ml of SDA was obtained for testing. The drug control used was Imidazole at a concentration of 100µg/ml of SDA. Butanol extracts...
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Posted by admin on Mar 30, 2015 in |
The present study discussed the nutritional content and quantification of eleven bioactive phenolic antioxidant contents in the water, methanol and acetone extracts of four different edible fruits viz. Musa acuminate (banana), Ananascomosus (pineapple), Psidiumguajava (guava) and Malusdomestica (apple) using HPLC-DAD. Nutritional analysis showed that the most moisture and fiber-containing fruit was guava where as banana had the lowest amount. On the other hand banana had the highest percentage of protein and carbohydrate whereas guava had the lowest percentage. The result showed that the antioxidant content determined by HPLC was varied in the water, methanol and acetone extracts of these fruits. According to the study, acetone was appeared as the most suitable extraction system of phenolic antioxidants present in these fruits, i.e. in the apple,(+) catechin hydrate was 486.80 ± 16.75, 28.64 ± 2.21and 0.0 ± 0.0 mg/100g of the extract; ellagic acid was 1735.14 ± 33.17, 33.44 ± 4.07 and 0.0 ± 0.0 mg/100g of the extract and (-) epicatechin was 138.02 ± 7.69, 6.78 ± 1.06 and 0.0...
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Posted by admin on Mar 30, 2015 in |
Leaves, rootstock, fruit and decoction of Lasia spinosa (Araceae) are used in folklore medicine for Gastrointestinal, Respiratory and Skin diseases. The intent of the present study was to evaluate the Antihyperlipidemic activity of methanolic leaves extract of Lasia spinosa and for its role in the prevention of hyperlipidemia induced pancreatitis in rats. The evaluation of the Antihyperlipidemic activity and the role of Lasia spinosa in the prevention of hyperlipidemia induced pancreatitis were done by means of Cholesterol 100 mg/kg body weight, p.o, induced hyperlipidemic model and Triton-X 100 (480 mg/kg, b.w; i.p.) induced hyperlipidemic model. The biochemical parameters such as Total Cholesterol, Triglycerides, LDL-C, HDL-C, VLDL-C, Serum Amylase, Serum Lipase and WBC Count were estimated to appraise its activity. A significant increase in the levels of biochemical and biological parameters was discerned in group 2 and a reversal in the extent was seen in the treated group of animals engaged in the study. The histopathological evaluations of Liver and Pancreas samples were in support of the obtained results. Based...
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