Posted by admin on Mar 30, 2015 in |
The pulsatile drug delivery works upon the system that releases active pharmaceutical ingredient completely and rapidly after a desired lag time. This type of approach was advantageous for: Drugswith extensive first pass metabolism and biological tolerance. Locally absorbed or acting drugs to a specific site in the intestinal tract (e.g. colon). Adaptation of therapy according to chronopharmacological needs. The pH-dependent polymers in pulsatile drug delivery were insoluble at low pH levels but with increase in pH solubility of polymer increases. The objective of present study was to develop a pulsatile compression coated tablet. The system was developed into two steps: Firstly core tablet was prepared containing Nifidipine as API. Secondly core tablet was coated with polymer blend of Eudragit S100and Eudragit L100. The lag time was the time in which less than 10% of drug was released. From in vitro release study we had concluded that drug release at pH 6.8 was inversely proportional to the amount of polymer Eudragit L100, which might be due to pH-dependent solubility of...
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Posted by admin on Mar 30, 2015 in |
Bone marrow aspiration can determine the metastatic deposits, degree of cellularity and fibrosis readily. A retrospective analysis of bone marrow aspiration and biopsy, in children and adult patients with hematological anomalies, were performed in 674 cases for different indication of hematological abnormalities from January 2013 to March 2014. Cases were analyzed in detail regarding clinical, hematological examination and family history. The mean age of the patients was 38.03 years ranging from 2 years to 78 years. Among 674 cases, 58.16 percent cases were male and 41.84 percent were female with sex ratio of 1.4:1. The commonest clinical & physical symptoms were pallor (87.5%), followed by weakness & headache (47.9%) and fever (37.9%). The most frequent malignant hematological anomalies in children (99.9%) and adults (50.49%) were acute leukemia, followed by multiple myeloma (17.82%) in adults only. Normoblastic marrow represented highest number of cases both in children (21.43%) and in adults (20.86%) as non-malignant hematological disorder. Bone marrow examination helps to assess the spectrum of hematological disorder in both children &...
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Posted by admin on Mar 30, 2015 in |
Molybdenum is a trace element distributed widely in nature which plays an important role in plant and animal nutrition and in our industrial society. Molybdenum is essentially present in the enzymes nitrogenase, Xanthine-oxidase, sulphite oxidas, nitrate reductase, formate dehydrogenase and aldehyde oxidase. These enzymes are responsible for a number of catalytic reactions of redox nature. Molybdenum complexes were synthesized and characterized for their purity by various physico-chemical methods like IR, Electronic, 1H1 NMR spectral studies Antimicrobial activity of compounds against certain microbial species has been carried out by serial dilution method using BOD incubator to evaluate the MIC (Minimum Inhibitory Concentration) value on the basis of MIC value it is interpretated that Molybdenum complexes are most active as compared to ligand fragments. The DNA binding ability of the complexes was examined by using biophysical spectroscopic studies. These studies indicate that the compounds can intercalate and stablize DNA. This work has great importance in the field of bioinorganic...
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Posted by admin on Mar 30, 2015 in |
The aim of the present study was to evaluate the anxiolytic effects and motor activity of ethanolic and aqueous extracts of leaves of Dendrophthoe falcata (DF) in mice. Swiss albino mice were treated orally with ethanolic and aqueous extracts of DF leaves (250 mg/kg and 500 mg/kg) and distilled water along with alprazolam (1 mg/kg) intraperitoneally for seven days and then exposed to Elevated Plus Maze (EPM) and Light Dark Box (LDB). The effects of the plant extracts on motor coordination were evaluated by Rota rod test. We further investigated the mechanism of action underlying the anxiolytic-like effect of the extracts by pre-treating animals with antagonist of benzodiazepine (flumazenil, 3mg/kg) prior to evaluation using EPM and LDB. Mice treated with ethanol DF extract (250 mg/kg) showed significant increase in; percentage of open arm entries, time spent in open arms of EPM and decrease in motor coordination in Rotarod test. Furthermore, the ethanol DF extracts (250 mg/kg and 500 mg/kg) significantly increased the percentage of time spent and number of...
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Posted by admin on Mar 30, 2015 in |
In diabetes, infertility is a common complication in diabetic men and experimental animals. The aim of this study was to investigate the protective effect of methanolic leaf extract of Clerodendrum infortunatum (MECI) on programmed cell death in the testicular damage resulting from streptozotocin (STZ) induced diabetes in rats. Diabetes was induced by a single intraperitoneal injection of STZ (50 mg/kg), and the rats were treated with MECI (250 mg/kg and 500 mg/kg) administered once a day orally for 28 days, starting 3 days after the STZ injection. Blood glucose were checked in diabetic induced animals. At the end of the study, all animals were sacrificed. Testis tissues were collected for the assessment of sperm parameters, and for biochemical and histopathological analysis. The MECI-treated rats in the diabetic group showed an improved blood sugar, histological appearance, sperm parameters and program cell death. These results suggest that methanolic leaf extract of Clerodendrum infortunatum is a potentially beneficial in reducing testicular damage in diabetic...
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