Posted by admin on Jan 31, 2015 in |
Traditional medicines in many developing countries rely on the plant phytochemicals as a source of drug in curing many diseases. Tagetes erecta Linn. is an ornamental plant containing valuable therapeutic phytochemicals. In the current investigation, ethanol extraction of the dried flower sample was subjected to column chromatographic separation. Around 185 fractions were separated and recorded with different Rf values. The fractions were analyzed qualitatively and it was proved that the flower sample was rich in tannins, saponins, carbohydrates, alkaloids, quinines, terpenoids, phenols and...
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Posted by admin on Jan 31, 2015 in |
Actinomycetes are versatile and prolific source of microbial natural products with great advantage in medicine and agriculture. Recently there is growing interest in exploring biological active compounds from rare actinomycetes. Usually rare actinomycetes are regarded as strains of actinomycetes whose isolation frequency by conventional methods is much lower than that of Streptomycetes strains. Amycolatopsis orientalis JAR10 rare genera of actinomycetes which have been isolated, characterized and antimicrobial activity against various pathogens have been determined in the present work. The morphological, cultural, genotypical and physiological characteristics of strain JAR10 has been examined by International Streptomyces Project. The bioactive metabolites produced by strain JAR10 were extracted by solvent extraction method and the crude extract obtained was further analyzed against various pathogens. The minimum inhibitory concentration of crude extract obtained from Amycolatopsis orientalis JAR10 was analyzed by broth dilution method and was found to inhibit Staphylococcus aureus at 60 µg/ml indicating the presence of biological active...
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Posted by admin on Jan 31, 2015 in |
In the present study reports synthesis and development of 3-Chloro – N – ((5-chloro-1-tosyl-1H-benzo [d] imidazol – 2 – yl) methyl) – N arylquinoxalin-2-amines (5a-e) from 3-chloro-N-p-tolyl quinoxalin -2-amine (3) condensed with proporgyl bromide followed by adding 4-chloro-N1-tosylbenzene-1,2-diamine,by adopting simple procedure. All titled compounds were screened for their anti bacterial activity by using bacterial strins i.e Bacillus subtilis MTCC 441, Bacillus cereus ATCC 9372, E.coli ATCC 8739, and staphylococcus aureus ATCC 96, compounds 5c, and 4c, were proven highest zone of inhibition against bacterial strains and 5b and 4b were also proven moderate inhibition zone against above mentioned bacterial strains, and the structures of synthesized compounds were characterized by 1HNMR, 13CNMR And Mass spectral...
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Posted by admin on Jan 31, 2015 in |
An efficient, cost effective use of Raney nickel (R-Ni) a widely used industrial catalyst for N-Alkylation using alcohols is highlighted here. The work describes the scope and capability of R-Ni in borrowing hydrogen reactions for Aniline and Benzyl alcohol. The reaction optimization is described using two techniques, Conventional and Design of experiment. The use of DOE for reaction optimization is an unique option described in this...
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Posted by admin on Jan 31, 2015 in |
Raise in the multidrug resistance gave challenge to the treatment of tuberculosis with first line medication due to less response. Nanoparticle drug delivery has proven efficiency in improving the therapeutic efficacy of many drugs. Reduction of dosing frequency was achieved by applying drug delivery using Nano medicine and Green Nanotechnology. The present study aimed in the production of such drug conjugates of Isoniazid using interdisciplinary technology of nano medicine and green nanotechnology. Isoniazid Nano-conjugates were produced by simple incubation and formed conjugates were analyzed for the efficiency of the plant extract to conjugate the drug. The therapeutic efficacy of the conjugated drug was evaluated using luciferase Reporter phage assay against M.tuberculosis H37RV. High drug entrapment efficiency of plant extract was achieved, ranging from 85-95% and effective particle sized drug-conjugates, ranging from 246-356nm were formed. The relative light units were also less indicating the persistence of activity of the Isoniazid and the inhibition was 93%. Hence Isoniazid Nano-conjugates have the potential for TB Chemotherapy which could be a cost-effective method...
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