Posted by admin on Dec 25, 2014 in |
Tannins, the non-nutritive substances from plant sources exhibit potent biological activities that lower the risk of chronic diseases without any side effects. Tannins are most abundant and multipotent molecules exhibiting antioxidant, proapoptotic and antiangiogenic activity and thus being effective in the treatment of degenerative diseases including initiation and progression of tumors. The study aims to prove the chemopreventive properties of tannins that target several key events involved in the development of cancer. Partially purified tannins from the acetone extract of Memecylon malabaricum was subjected to shell less CAM assay and in vitro studies to note the antiangiogenic and antioxidant activities respectively, while the proapoptotic activity was noted by its effect on EAT cells. Inhibiting the proliferation of capillaries in shell less CAM assay proved their antiangiogenic property. 1, 1-diphenyl 2-picrylhydrazyl (DPPH) radical scavenging activity (EC50 of 2.67 µg/ml), Hydroxyl radical scavenging activity (EC50 of 7.73 µg/ml), Nitric oxide radical scavenging activity (EC50 of 11.3 µg/ml) and superoxide anion radical scavenging activity (EC50 of 19 µg/ml) established their antioxidant activity,...
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Posted by admin on Dec 25, 2014 in |
The two pure phytochemicals characterized as cis-piperine and trans-piperine isolated from the dried fruits of Piper longum were tested for antihepatotoxic activity at the dose of 50 mg/kg orally respectively, against silymarin as a standard reference. The toxicity was induced by CCl4, and then various biological parameters such as AST, ALT, ALP, SOD, GPx, GSH, total protein, total albumin and total bilirubin were measured at 134.24 IU/L 71.96 IU/L, 375.02 IU/L, 37.02 U/g, 17.02 U/g, 29.12 U/g, 1.95 g/dl, 1.09 g/dl, 4.16 g/dl respectively. The phytochemicals cis-piperine and trans-piperine showed significant antihepatotoxic activity. Both cis-piperine and trans-piperine exhibited antihepatotoxic activity by reducing the increased levels of serum AST by 90.14%, 91.19% ALT by 82.65%, 58.12% and ALP by 97.37%, 92.23% when compared with standard drug silymarin that have decreased AST by 91.64%, ALT by 89.92%, ALP by 94.54%, respectively, and by elevation in the antioxidants SOD, GPx, and GSH) respectively, and total albumin, total protein. The overall experimental results have suggested that the both the isomers of piperine possessed...
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Posted by admin on Dec 25, 2014 in |
The aim of this study was to investigate the possible anticonvulsant effect of a Dihydropyridine calcium antagonist, Isradipine, which easily crosses the blood–brain barrier displaying high affinity and specificity for the brain L-type voltage-sensitive calcium channel, on maximal electroshock seizures and PTZ induced seizures. The seizures were induced in rats by maximum electroshock method and chemically by pentylenetetrazole (PTZ). Isradipine delayed the onset of action and time of death to 213.21 ± 32.46 seconds and 952.85 ± 9.81 seconds respectively when compared with control in PTZ induces seizures model. The present study indicates that Isradipine showed significant anticonvulsant effect against maximal electroshock and PTZ induced convulsion in...
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Posted by admin on Dec 25, 2014 in |
The present study enumerates the synthesis, spectroscopic characterization, and evaluation of antitumor properties of esters of two fatty acids viz., 5-hexenoic acid and iso- ricinoleic acid with 2, 4- or 2, 6-diisopropylphenol (Propofol). Propofol is a potent intravenous hypnotic agent which is widely used for the induction and maintenance of anesthesia and for sedation in the intensive care unit. Propofol also possess anti-cancer properties in addition to its sedative effects. Cytotoxicity of all the synthesized compounds was examined against a panel of four human solid tumor cell lines, SK-MEL, KB, BT-549, SK-OV-3, and one human leukemia cell line, HL-60. To compare their tumor selectivity over normal cell lines, VERO cells were also included. The results indicate that these novel conjugates might represent a new class of anti-tumor agents that possess selectivity toward cancer cells over normal...
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Posted by admin on Dec 25, 2014 in |
The present study aimed to evaluate bioactive compounds and total antioxidant activity of differentfruits viz Phyllanthus emblica, Limonia acidissima, Syzygium cumini, Artocarpus hirsutus, Carissa congesta, Anacardium occidentale. Phytochemical study confirms the presence of carbohydrates, proteins, amino acids, cardiac glycosides, steroids, terpenoids and flavonoids in all the fruit extract. Ascorbic acid was used as a standard antioxidant. The reducing power and total antioxidant activity were high in Phyllanthus emblica and low in Carissa congesta. In DPPH assay Phyllanthus emblica exhibited highest activity whereas A.hirsutus showed lowest activity. Thus the study suggests that Phyllanthus emblicafruit is a better source of natural antioxidant, which might be helpful in preventing oxidative stress related...
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